Presence of Tumor Necrosis Factor-Alpha in Urine Samples of Patients With Chronic Low Back Pain Undergoing Chiropractic Care: Preliminary Findings From a Prospective Cohort Study.
| Title: | Presence of Tumor Necrosis Factor-Alpha in Urine Samples of Patients With Chronic Low Back Pain Undergoing Chiropractic Care: Preliminary Findings From a Prospective Cohort Study. |
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| Authors: | Gevers-Montoro C; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Romero-Santiago M; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.; Losapio L; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.; Conesa-Buendía FM; Instituto de Investigación Sanitaria, Fundación Jiménez-Díaz, Madrid, Spain.; Newell D; Chiropractic Department, AECC University College, Bournemouth, United Kingdom.; Álvarez-Galovich L; Instituto de Investigación Sanitaria, Fundación Jiménez-Díaz, Madrid, Spain.; Piché M; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Ortega-De Mues A; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain. |
| Source: | Frontiers in integrative neuroscience [Front Integr Neurosci] 2022 Apr 12; Vol. 16, pp. 879083. Date of Electronic Publication: 2022 Apr 12 (Print Publication: 2022). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477950 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5145 (Print) Linking ISSN: 16625145 NLM ISO Abbreviation: Front Integr Neurosci Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007- |
| Abstract: | Background and Aims: Low back pain is the leading cause of years lived with disability worldwide. Chiropractors employ different interventions to treat low back pain, including spinal manipulative therapy, although the mechanisms through which chiropractic care improves low back pain are still unclear. Clinical research and animal models suggest that spinal manipulation might modulate plasma levels of inflammatory cytokines, which have been involved in different stages of low back pain. More specifically, serum levels of Tumor Necrosis Factor-alpha (TNF-α) have been found to be elevated in patients with chronic low back pain. We aimed to investigate whether urine from chronic low back pain patients could be an appropriate medium to measure concentrations of TNF-α and to examine possible changes in its levels associated to chiropractic care.; Methods: Urine samples were collected from 24 patients with chronic low back pain and TNF-α levels were analyzed by ELISA before and after 4-6 weeks of care compared to a reference value obtained from 5 healthy control subjects, by means of a Welch's t-test. Simultaneously, pain intensity and disability were also evaluated before and after care. Paired t-tests were used to compare mean pre and post urinary concentrations of TNF-α and clinical outcomes.; Results: Significantly higher baseline levels of urinary TNF-α were observed in chronic low back pain patients when compared to our reference value (p < 0.001), which were significantly lower after the period of chiropractic treatment (p = 0.03). Moreover, these changes were accompanied by a significant reduction in pain and disability (both p < 0.001). However, levels of urinary TNF-α were not correlated with pain intensity nor disability.; Conclusion: These results suggest that urine could be a good milieu to assess TNF-α changes, with potential clinical implications for the management of chronic low back pain.; (Copyright © 2022 Gevers-Montoro, Romero-Santiago, Losapio, Conesa-Buendía, Newell, Álvarez-Galovich, Piché and Ortega-De Mues.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| References: | Spine (Phila Pa 1976). 2019 Aug 1;44(15):E914-E926. (PMID: 31335790); J Immunol. 2010 Sep 15;185(6):3694-701. (PMID: 20713883); Clin J Pain. 2018 Jan;34(1):68-75. (PMID: 29200015); Front Biosci. 1997 Jan 01;2:d12-26. (PMID: 9159205); Spine (Phila Pa 1976). 2018 Oct 15;43(20):E1184-E1194. (PMID: 30273227); Eur J Pain. 2017 Feb;21(2):201-216. (PMID: 27712027); Nat Rev Rheumatol. 2014 Jan;10(1):44-56. (PMID: 24166242); PLoS One. 2013 Dec 12;8(12):e76091. (PMID: 24348989); Chiropr Man Therap. 2017 Nov 22;25:35. (PMID: 29201346); Science. 2016 Nov 4;354(6312):572-577. (PMID: 27811267); BMJ. 2019 Mar 13;364:l689. (PMID: 30867144); Spine (Phila Pa 1976). 2008 Jan 1;33(1):90-4. (PMID: 18165753); Chiropr Man Therap. 2021 Jan 8;29(1):3. (PMID: 33413508); J Manipulative Physiol Ther. 2016 Jan;39(1):42-53. (PMID: 26837229); Eur J Heart Fail. 2003 Jan;5(1):27-31. (PMID: 12559212); Cytokine. 2013 Dec;64(3):660-5. (PMID: 24128872); J Proteomics Bioinform. 2015;2015(Suppl 14):. (PMID: 27212868); J Chiropr Med. 2010 Sep;9(3):107-14. (PMID: 22027032); Front Pain Res (Lausanne). 2021 Oct 25;2:765921. (PMID: 35295422); Clin J Pain. 2019 Oct;35(10):818-825. (PMID: 31283548); Exp Biol Med (Maywood). 2016 Apr;241(8):783-99. (PMID: 27013544); Anesthesiology. 2018 Aug;129(2):343-366. (PMID: 29462012); J Hypertens. 2008 Dec;26(12):2445-9. (PMID: 19008724); Clin J Pain. 2008 Mar-Apr;24(3):273-8. (PMID: 18287835); J Biochem. 2015 Oct;158(4):299-308. (PMID: 25922201); Biosci Rep. 2016 Aug 05;36(4):. (PMID: 27380953); Eur Spine J. 2016 May;25(5):1428-1434. (PMID: 26684469); J Neurosci. 2008 May 14;28(20):5189-94. (PMID: 18480275); Pain Med. 2016 Jan;17(1):40-5. (PMID: 26243249); Mol Pain. 2018 Jan-Dec;14:1744806918799127. (PMID: 30124090); Biochem Cell Biol. 2018 Aug;96(4):450-456. (PMID: 29324184); BMC Musculoskelet Disord. 2020 Mar 3;21(1):142. (PMID: 32126991); Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3731-6. (PMID: 21245297); Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F874-F880. (PMID: 31390230); Ann Intern Med. 2017 Apr 4;166(7):514-530. (PMID: 28192789); Eur J Pain. 2021 Aug;25(7):1429-1448. (PMID: 33786932); Nat Rev Dis Primers. 2018 Dec 13;4(1):52. (PMID: 30546064); Inflamm Res. 2007 Jan;56(1):32-7. (PMID: 17334668); BMC Musculoskelet Disord. 2013 Apr 26;14:148. (PMID: 23622053); Lancet. 2018 Jun 9;391(10137):2356-2367. (PMID: 29573870); J Neuroimmunol. 2000 Feb 1;103(1):34-40. (PMID: 10674987); Clin Spine Surg. 2017 Jul;30(6):E690-E701. (PMID: 28632555); Rehabilitacion (Madr). 2020 Jan - Mar;54(1):25-30. (PMID: 32007179); Musculoskelet Sci Pract. 2021 Feb;51:102307. (PMID: 33254007); Eur Spine J. 2018 Aug;27(8):1744-1756. (PMID: 29948327); J Manipulative Physiol Ther. 2006 Jan;29(1):14-21. (PMID: 16396725); J Manipulative Physiol Ther. 2016 Jan;39(1):1-22. (PMID: 26804581); Inflammopharmacology. 2019 Aug;27(4):679-683. (PMID: 30675683); Spine (Phila Pa 1976). 2011 Feb 1;36(3):230-42. (PMID: 21248591); Clin J Pain. 2020 May;36(5):379-389. (PMID: 31990692); Brain Behav Immun. 2017 Feb;60:84-92. (PMID: 27720935); Pain. 2016 Jan;157(1):70-79. (PMID: 26230740) |
| Contributed Indexing: | Keywords: chiropractic; chronic pain; inflammatory cytokines; low back pain; tumor necrosis factor alpha; urinalysis |
| Entry Date(s): | Date Created: 20220502 Latest Revision: 20231102 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9039288 |
| DOI: | 10.3389/fnint.2022.879083 |
| PMID: | 35492573 |
| Database: | MEDLINE |
Journal Article