Early brain and abdominal oxygenation in extremely low birth weight infants.
| Title: | Early brain and abdominal oxygenation in extremely low birth weight infants. |
|---|---|
| Authors: | Chock VY; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA. vchock@stanford.edu.; Smith E; Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Rockville, NC, USA.; Tan S; Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Rockville, NC, USA.; Ball MB; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.; Das A; Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.; Hintz SR; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.; Kirpalani H; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.; Bell EF; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.; Chalak LF; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Carlo WA; Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.; Cotten CM; Department of Pediatrics, Duke University, Durham, NC, USA.; Widness JA; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.; Kennedy KA; Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.; Ohls RK; University of New Mexico Health Sciences Center, Albuquerque, NM, USA.; Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.; Seabrook RB; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.; Patel RM; Emory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Laptook AR; Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.; Mancini T; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.; Sokol GM; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.; Walsh MC; Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.; Yoder BA; Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.; Poindexter BB; Emory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Chawla S; Department of Pediatrics, Wayne State University, Detroit, MI, USA.; D'Angio CT; University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.; College of Health and Human Services, George Mason University, Fairfax, VA, USA.; Van Meurs KP; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA. |
| Corporate Authors: | Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network |
| Source: | Pediatric research [Pediatr Res] 2022 Oct; Vol. 92 (4), pp. 1034-1041. Date of Electronic Publication: 2022 May 05. |
| Publication Type: | Multicenter Study; Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2012- : New York : Nature Publishing Group; Original Publication: Basel ; New York : Karger. |
| MeSH Terms: | Infant, Premature* ; Infant, Extremely Low Birth Weight*; Pregnancy ; Female ; Infant, Newborn ; Humans ; Birth Weight ; Prospective Studies ; Oxygen ; Brain ; Hemoglobins ; Cerebrovascular Circulation |
| Abstract: | Background: Extremely low birth weight (ELBW) infants are at risk for end-organ hypoxia and ischemia. Regional tissue oxygenation of the brain and gut as monitored with near-infrared spectroscopy (NIRS) may change with postnatal age, but normal ranges are not well defined.; Methods: A prospective study of ELBW preterm infants utilized NIRS monitoring to assess changes in cerebral and mesenteric saturation (Csat and Msat) over the first week after birth. This secondary study of a multicenter trial comparing hemoglobin transfusion thresholds assessed cerebral and mesenteric fractional tissue oxygen extraction (cFTOE and mFTOE) and relationships with perinatal variables.; Results: In 124 infants, both Csat and Msat declined over the first week, with a corresponding increase in oxygen extraction. With lower gestational age, lower birth weight, and 5-min Apgar score ≤5, there was a greater increase in oxygen extraction in the brain compared to the gut. Infants managed with a lower hemoglobin transfusion threshold receiving ≥2 transfusions in the first week had the lowest Csat and highest cFTOE (p |
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| Grant Information: | UG1 HD068263 United States HD NICHD NIH HHS; U10 HD021373 United States HD NICHD NIH HHS; UG1 HD087226 United States HD NICHD NIH HHS; UG1 HD053089 United States HD NICHD NIH HHS; UG1 HD027856 United States HD NICHD NIH HHS; UG1 HD034216 United States HD NICHD NIH HHS; UG1 HD027904 United States HD NICHD NIH HHS; UG1 HD027880 United States HD NICHD NIH HHS; UL1 TR001117 United States TR NCATS NIH HHS; UG1 HD053109 United States HD NICHD NIH HHS; UG1 HD027851 United States HD NICHD NIH HHS; U10 HD036790 United States HD NICHD NIH HHS; UG1 HD068278 United States HD NICHD NIH HHS; U01 HD036790 United States HD NICHD NIH HHS; U01 HL112776 United States HL NHLBI NIH HHS; R01 HL122167 United States HL NHLBI NIH HHS; UG1 HD068270 United States HD NICHD NIH HHS; UG1 HD068244 United States HD NICHD NIH HHS; UG1 HD027853 United States HD NICHD NIH HHS; UG1 HD087229 United States HD NICHD NIH HHS; U01 HL112748 United States HL NHLBI NIH HHS; UG1 HD040689 United States HD NICHD NIH HHS; UG1 HD068284 United States HD NICHD NIH HHS; UG1 HD021385 United States HD NICHD NIH HHS; UG1 HD040492 United States HD NICHD NIH HHS; UG1 HD021364 United States HD NICHD NIH HHS |
| Substance Nomenclature: | S88TT14065 (Oxygen); 0 (Hemoglobins) |
| Entry Date(s): | Date Created: 20220505 Date Completed: 20221025 Latest Revision: 20221221 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9588487 |
| DOI: | 10.1038/s41390-022-02082-z |
| PMID: | 35513716 |
| Database: | MEDLINE |
Multicenter Study; Journal Article; Research Support, N.I.H., Extramural