The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study.
| Title: | The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study. |
|---|---|
| Authors: | Donadio V; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Incensi A; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Rizzo G; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Fileccia E; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Ventruto F; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Riva A; R&D Department, Indena S.p.A., Milan, Italy.; Tiso D; Medical Department, Agave Group, Bologna, Italy.; Recchia M; R&D Department, Indena S.p.A., Milan, Italy.; Vacchiano V; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Infante R; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Petrangolini G; R&D Department, Indena S.p.A., Milan, Italy.; Allegrini P; R&D Department, Indena S.p.A., Milan, Italy.; Avino S; Medical Department, Agave Group, Bologna, Italy.; Pantieri R; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia, Bologna, Italy.; Mostacci B; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Avoni P; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Italy.; Liguori R; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Italy. |
| Source: | Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2022 Jun 20; Vol. 81 (7), pp. 545-552. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 2985192R Publication Model: Print Cited Medium: Internet ISSN: 1554-6578 (Electronic) Linking ISSN: 00223069 NLM ISO Abbreviation: J Neuropathol Exp Neurol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2016- : Oxford, England : Oxford University Press; Original Publication: Lawrence, Ks : Association of the journal of neuropathology and experimental neurology |
| MeSH Terms: | Curcumin*/therapeutic use ; Parkinson Disease*/drug therapy ; Parkinson Disease*/pathology; Skin/pathology ; Biopsy ; Humans |
| Abstract: | There are currently no standardized therapies for Parkinson disease (PD). Curcumin shows anti-amyloidogenic properties in vitro and may be a promising treatment for PD. We evaluated the effects of curcumin supplementation on clinical scales and misfolded, phosphorylated α-synuclein (p-syn) accumulation in skin biopsies in 19 PD patients who received curcumin supplementation for 12 months and 14 PD patients to treated with curcumin. The patients underwent autonomic (COMPASS-31), motor (MDS-UPDRS and H&Y) and nonmotor (NMSS) questionnaires and skin biopsies to evaluate clinical involvement and p-syn load in skin nerves at the beginning and the end of study. Curcumin and curcuminoid levels were assayed in plasma and CSF. Supplemented patients showed detectable CSF curcuminoid levels that were lower than those in plasma. They showed a decrease of COMPASS-31 and NMSS scores, and a slight p-syn load decrease versus untreated patients who displayed a worsening of these parameters despite increased levodopa doses. Multiple regression models showed a significant effect of curcumin supplementation in decreasing the worsening of the clinical parameters and p-syn load at after curcumin treatment. These data suggest that curcumin can cross the blood-brain barrier, that it is effective in ameliorating clinical parameters and that it shows a tendency to decrease skin p-syn accumulation in PD patients.; (© 2022 American Association of Neuropathologists, Inc. All rights reserved.) |
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| Contributed Indexing: | Keywords: Clinical scales; Curcumin; Dietary supplement; Parkinson disease; Protein misfolding; Skin biopsy; α-Synuclein |
| Substance Nomenclature: | IT942ZTH98 (Curcumin) |
| Entry Date(s): | Date Created: 20220513 Date Completed: 20220622 Latest Revision: 20220821 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9210322 |
| DOI: | 10.1093/jnen/nlac034 |
| PMID: | 35556131 |
| Database: | MEDLINE |
Journal Article