Frailty in Parkinson's disease and its association with early dementia: A longitudinal study.
| Title: | Frailty in Parkinson's disease and its association with early dementia: A longitudinal study. |
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| Authors: | Borda MG; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana. Bogotá, Colombia; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway. Electronic address: mmborda@gmail.com.; Pérez-Zepeda MU; Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana. Bogotá, Colombia; Geriatric Medicine Research, Dalhousie University, Nova Scotia Health Authority, Halifax, NS, Canada; Geriatric Epidemiology Research Department, Instituto Nacional De Geriatría (INGER), Mexico City, Mexico; Centro de Investigación en Ciencias de la Salud (CICSA), FCS, Universidad Anáhuac México Campus Norte, Huixquilucan Edo. de México, Mexico.; Jaramillo-Jimenez A; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; Grupo de Neurociencias de Antioquia, School of Medicine, Universidad de Antioquia, Medellín, Colombia.; Chaudhuri KR; Parkinson Foundation Centre of Excellence at King's College Hospital and Kings College, Denmark Hill, London, SE5 9RS, United Kingdom; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RT, UK.; Tovar-Rios DA; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Faculty of Health Sciences, University of Stavanger, Stavanger, Norway; Grupo INFERIR, Facultad de Ingeniería, Universidad del Valle, Santiago de Cali, Valle del Cauca, Colombia.; Wallace L; Geriatric Medicine Research, Dalhousie University, Nova Scotia Health Authority, Halifax, NS, Canada; Cambridge Public Health, University of Cambridge, Cambridge, United Kingdom.; Batzu L; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, United Kingdom.; Rockwood K; Geriatric Medicine Research, Dalhousie University, Nova Scotia Health Authority, Halifax, NS, Canada.; Tysnes OB; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Aarsland D; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital. Stavanger, Norway; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, United Kingdom.; Alves G; The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway. |
| Source: | Parkinsonism & related disorders [Parkinsonism Relat Disord] 2022 Jun; Vol. 99, pp. 51-57. Date of Electronic Publication: 2022 May 13. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kidlington, Oxford, U.K. ; Tarrytown, NY : Elsevier Science, c1995- |
| MeSH Terms: | Alzheimer Disease*/complications ; Frailty*/epidemiology ; Parkinson Disease*/complications ; Parkinson Disease*/epidemiology; Aged ; Frail Elderly ; Humans ; Longitudinal Studies |
| Abstract: | Introduction: Frailty is recognized as a clinical condition associated with increased vulnerability for developing negative health outcomes but has been little studied in patients with Parkinson's disease (PD). Here, we investigated the risk of frailty in de novo PD patients and its association with subsequent development of dementia.; Methods: We conducted a three-year longitudinal population-based study of 192 drug-naive newly diagnosed PD patients and 172 controls (No-PD) matched for age, sex, and education. Frailty was measured using the frailty index (FI). Logistic regression models, adjusting for potential confounders, were conducted to assess the association between frailty at the time of PD diagnosis and the subsequent odds for developing PD dementia during follow-up.; Results: The mean baseline FI score was higher in the PD (0.21 ± 0.10) than in the No-PD group (0.11 ± 0.07, p 0,25), compared to 5% in the no-PD group. Participants with PD had an increased risk to present frailty with an odds ratio (OR) of 6.68 (SE 2.70 IC 95% [3.15; 15.62], p-value |
| Grant Information: | United Kingdom DH_ Department of Health; Canada CIHR |
| Contributed Indexing: | Keywords: Dementia; Frailty; Older adults; Parkinson's disease |
| Entry Date(s): | Date Created: 20220522 Date Completed: 20220628 Latest Revision: 20220719 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.parkreldis.2022.05.004 |
| PMID: | 35598420 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't