An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases.
| Title: | An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. |
|---|---|
| Authors: | Teleanu DM; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Niculescu AG; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; Lungu II; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Institute of Laser, Plasma and Radiation Physics (NILPRP), 077125 Magurele, Romania.; Radu CI; Department of Neurosurgery (I), Bucharest University Emergency Hospital, 050098 Bucharest, Romania.; Vladâcenco O; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Pediatric Neurology, 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; Roza E; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Pediatric Neurology, 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; Costăchescu B; 'Gr. T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; 'Prof. Dr. N. Oblu' Emergency Clinical Hospital, 700309 Iasi, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; ICUB-Research Institute of University of Bucharest, University of Bucharest, 050657 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Teleanu RI; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Pediatric Neurology, 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania. |
| Source: | International journal of molecular sciences [Int J Mol Sci] 2022 May 25; Vol. 23 (11). Date of Electronic Publication: 2022 May 25. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2000- |
| MeSH Terms: | Neurodegenerative Diseases*/pathology; Antioxidants/therapeutic use ; Oxidative Stress/physiology ; Humans ; Neuroinflammatory Diseases ; Reactive Oxygen Species |
| Abstract: | Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Oxidative stress was also noted to modify the inflammatory response. Even though oxidative stress and neuroinflammation are two totally different pathological events, they are linked and affect one another. Nonetheless, there are still several mechanisms that need to be understood regarding the onset and the progress of neurodegenerative diseases in order to develop efficient therapies. As antioxidants are a means to alter oxidative stress and slow down the symptoms of these neurodegenerative diseases, the most common antioxidants, enzymatic as well as non-enzymatic, have been mentioned in this paper as therapeutic options for the discussed disorders. |
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| Contributed Indexing: | Keywords: antioxidants; neurodegenerative disease; neuroinflammation; reactive oxidative species |
| Substance Nomenclature: | 0 (Antioxidants); 0 (Reactive Oxygen Species) |
| Entry Date(s): | Date Created: 20220610 Date Completed: 20220613 Latest Revision: 20220716 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9180653 |
| DOI: | 10.3390/ijms23115938 |
| PMID: | 35682615 |
| Database: | MEDLINE |
Journal Article; Review