Neurotransmitters-Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System.
| Title: | Neurotransmitters-Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System. |
|---|---|
| Authors: | Teleanu RI; Department of Pediatric Neurology, 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Niculescu AG; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Roza E; Department of Pediatric Neurology, 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Vladâcenco O; Department of Pediatric Neurology, 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Teleanu DM; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania. |
| Source: | International journal of molecular sciences [Int J Mol Sci] 2022 May 25; Vol. 23 (11). Date of Electronic Publication: 2022 May 25. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2000- |
| MeSH Terms: | Neurodegenerative Diseases*/metabolism ; Neuropeptides*/metabolism; Brain/metabolism ; Central Nervous System/metabolism ; Neurotransmitter Agents/metabolism ; Humans |
| Abstract: | Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role in information transmission throughout the nervous system. Hundreds of such chemicals have been discovered in the last century, continuing to be identified and studied concerning their action on brain health. These substances have been observed to influence numerous functions, including emotions, thoughts, memories, learning, and movements. Thus, disturbances in neurotransmitters' homeostasis started being correlated with a plethora of neurological and neurodegenerative disorders. In this respect, the present paper aims to describe the most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) and noncanonical neurotransmitters (e.g., exosomes, steroids, D-aspartic acid), and explain their link with some of the most relevant neurological conditions. Moreover, a brief overview of the recently developed neurotransmitters' detection methods is offered, followed by several considerations on the modulation of these substances towards restoring homeostasis. |
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| Contributed Indexing: | Keywords: neurodegenerative disorders; neurological disorders; neurotransmitters; neurotransmitters detection; neurotransmitters modulation |
| Substance Nomenclature: | 0 (Neuropeptides); 0 (Neurotransmitter Agents) |
| Entry Date(s): | Date Created: 20220610 Date Completed: 20220613 Latest Revision: 20240829 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9180936 |
| DOI: | 10.3390/ijms23115954 |
| PMID: | 35682631 |
| Database: | MEDLINE |
Journal Article; Review