Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity.
| Title: | Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity. |
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| Authors: | Zdravkovic M; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Popadic V; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Klasnja S; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Milic N; Institute for Medical Statistics and Informatics, Faculty of Medicine University of Belgrade, Belgrade, Serbia.; Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MI, United States.; Rajovic N; Institute for Medical Statistics and Informatics, Faculty of Medicine University of Belgrade, Belgrade, Serbia.; Divac A; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Manojlovic A; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Nikolic N; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Lukic F; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Rasiti E; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Mircetic K; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Marinkovic D; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Nikolic S; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Crnokrak B; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Lisulov DP; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Djurasevic S; Faculty of Biology, University of Belgrade, Belgrade, Serbia.; Stojkovic M; School of Medicine, University of Belgrade, Belgrade, Serbia.; Todorovic Z; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Lasica R; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Clinical Center of Serbia, Belgrade, Serbia.; Parapid B; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Clinical Center of Serbia, Belgrade, Serbia.; Djuran P; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.; Brajkovic M; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2022 Jun 15; Vol. 13, pp. 898072. Date of Electronic Publication: 2022 Jun 15 (Print Publication: 2022). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Media] |
| Abstract: | Introduction: The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well as to address the importance of obesity as a common comorbidity in patients with obstructive sleep apnea (OSA). Methods: The study was conducted as a prospective cohort study including 120 patients with newly diagnosed OSA between 2019 and 2020, at University Clinical Hospital Center "Bezanijska kosa", Belgrade, Serbia. The diagnosis was established by polysomnography. In all patients, sociodemographic data, respiratory, lipid, and inflammatory parameters were collected and complete echocardiographic study and 24-h blood pressure monitoring were performed. Results: The mean patient age was 55.7 ± 13.8 years. Study population was mostly male (70.0%) and obese (56.7%). At least 30 apneas or hypopneas per hour were present in 39.0% of patients. A strong positive correlation was found between OSA severity and BMI (r = 0.562, p < 0.001), both associated with lipid, inflammatory and respiratory parameters, and cardiovascular profile of patients with OSA (p < 0.05 for all). Echocardiographic study and 24-h blood pressure monitoring parameters were in turn correlated with lipid and inflammatory markers (p < 0.05 for all). Conclusion: The results of this study support the important role of dyslipidemia and inflammation, as well as coexistence of obesity in the pathogenesis of numerous conditions linked with an increased risk of cardiovascular morbidity and mortality in patients with OSA.; (Copyright © 2022 Zdravkovic, Popadic, Klasnja, Milic, Rajovic, Divac, Manojlovic, Nikolic, Lukic, Rasiti, Mircetic, Marinkovic, Nikolic, Crnokrak, Lisulov, Djurasevic, Stojkovic, Todorovic, Lasica, Parapid, Djuran and Brajkovic.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: cardiovascular risk; dyslipidemia; echocardiography; inflammation; obstructive sleep apnea |
| Entry Date(s): | Date Created: 20220705 Latest Revision: 20220716 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9240428 |
| DOI: | 10.3389/fphar.2022.898072 |
| PMID: | 35784707 |
| Database: | MEDLINE |
Journal Article