Peripheral lymphocyte subset alteration in patients with COVID-19 having differential clinical manifestations.
| Title: | Peripheral lymphocyte subset alteration in patients with COVID-19 having differential clinical manifestations. |
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| Authors: | Tripathy AS; Hepatitis Group, ICMR- National Institute of Virology, Pune, Maharashtra, India.; Trimbake D; Hepatitis Group, ICMR- National Institute of Virology, Pune, Maharashtra, India.; Suryawanshi PV; Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, Maharashtra, India.; Tripathy SP; Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, Maharashtra, India.; Gurav YK; Epidemiology Group, ICMR- National Institute of Virology, Pune, Maharashtra, India.; Potdar VA; Influenza group, ICMR- National Institute of Virology, Pune, Maharashtra, India.; Chaudhary ML; Influenza group, ICMR- National Institute of Virology, Pune, Maharashtra, India.; Athavale P; Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, Maharashtra, India.; Mokashi ND; Department of Microbiology, Yashwantrao Chavan Hospital, Pimpri Chinchwad Municipal Corporation, Pune, Maharashtra, India.; Patsute SD; Naidu Hospital, Pune Municipal Corporation, Pune, Maharashtra, India.; Kakrani AL; Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pune, Maharashtra, India.; Abraham P; ICMR- National Institute of Virology, Pune, Maharashtra, India. |
| Source: | The Indian journal of medical research [Indian J Med Res] 2022 Jan; Vol. 155 (1), pp. 136-147. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Scientific Scholar Country of Publication: United States NLM ID: 0374701 Publication Model: Print Cited Medium: Internet ISSN: 0971-5916 (Print) Linking ISSN: 09715916 NLM ISO Abbreviation: Indian J Med Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Pittsford, NY] : Scientific Scholar; Original Publication: New Delhi : Council Of Medical Research |
| MeSH Terms: | COVID-19*; India/epidemiology ; Humans ; Lymphocyte Count ; Lymphocyte Subsets ; Oxygen ; SARS-CoV-2 |
| Abstract: | Background & Objectives: The COVID-19 disease profile in Indian patients has been found to be different from the Western world. Changes in lymphocyte compartment have been correlated with disease course, illness severity and clinical outcome. This study was aimed to assess the peripheral lymphocyte phenotype and subset distribution in patients with COVID-19 disease from India with differential clinical manifestations.; Methods: Percentages of peripheral lymphocyte subsets were measured by flow cytometry in hospitalized asymptomatic (n=53), mild symptomatic (n=36), moderate and severe (n=30) patients with SARS-CoV-2 infection, recovered individuals (n=40) and uninfected controls (n=56) from Pune, Maharashtra, India.; Results: Percentages of CD4+Th cells were significantly high in asymptomatic, mild symptomatic, moderate and severe patients and recovered individuals compared to controls. Percentages of Th memory (CD3+CD4+CD45RO+), Tc memory (CD3+CD8+CD45RO+) and B memory (CD19+CD27+) cells were significantly higher in the recovered group compared to both asymptomatic, mild symptomatic patient and uninfected control groups. NK cell (CD56+CD3-) percentages were comparable among moderate +severe patient and uninfected control groups.; Interpretation & Conclusions: The observed lower CD4+Th cells in moderate+severe group requiring oxygen support compared to asymptomatic+mild symptomatic group not requiring oxygen support could be indicative of poor prognosis. Higher Th memory, Tc memory and B memory cells in the recovered group compared to mild symptomatic patient groups might be markers of recovery from mild infection; however, it remains to be established if the persistence of any of these cells could be considered as a correlate of protection. |
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| Contributed Indexing: | Keywords: Asymptomatic; SARS-CoV-2; lymphocyte subset; mild symptomatic; moderate +severe patients; recovered individuals |
| Substance Nomenclature: | S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20220721 Date Completed: 20220722 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9552374 |
| DOI: | 10.4103/ijmr.IJMR_453_21 |
| PMID: | 35859440 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't