Sleep Restriction and Recurrent Circadian Disruption Differentially Affects Blood Pressure, Sodium Retention, and Aldosterone Secretion.
| Title: | Sleep Restriction and Recurrent Circadian Disruption Differentially Affects Blood Pressure, Sodium Retention, and Aldosterone Secretion. |
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| Authors: | McMullan CJ; Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; McHill AW; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States.; Sleep, Chronobiology, and Health Laboratory, School of Nursing, Oregon Health & Science University, Portland, OR, United States.; Hull JT; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States.; Wang W; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States.; Forman JP; Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Klerman EB; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States.; Department of Neurology, Massachusetts General Hospital, Boston, MA, United States. |
| Source: | Frontiers in physiology [Front Physiol] 2022 Jul 08; Vol. 13, pp. 914497. Date of Electronic Publication: 2022 Jul 08 (Print Publication: 2022). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Research Foundation |
| Abstract: | Prolonged exposure to chronic sleep restriction (CSR) and shiftwork are both associated with incident hypertension and cardiovascular disease. We hypothesized that the combination of CSR and shiftwork's rotating sleep schedule (causing recurrent circadian disruption, RCD) would increase blood pressure, renal sodium retention, potassium excretion, and aldosterone excretion. Seventeen healthy participants were studied during a 32-day inpatient protocol that included 20-h "days" with associated scheduled sleep/wake and eating behaviors. Participants were randomly assigned to restricted (1:3.3 sleep:wake, CSR group) or standard (1:2 sleep:wake, Control group) ratios of sleep:wake duration. Systolic blood pressure during circadian misalignment was ∼6% higher in CSR conditions. Renal sodium and potassium excretion showed robust circadian patterns; potassium excretion also displayed some influence of the scheduled behaviors (sleep/wake, fasting during sleep so made parallel fasting/feeding). In contrast, the timing of renal aldosterone excretion was affected predominately by scheduled behaviors. Per 20-h "day," total sodium excretion increased, and total potassium excretion decreased during RCD without a change in total aldosterone excretion. Lastly, a reduced total renal sodium excretion was found despite constant oral sodium consumption and total aldosterone excretion, suggesting a positive total body sodium balance independent of aldosterone excretion. These findings may provide mechanistic insight into the observed adverse cardiovascular and renal effects of shiftwork.; (Copyright © 2022 McMullan, McHill, Hull, Wang, Forman and Klerman.) |
| Competing Interests: | AM reports consultancy for Somni Coporation; EK has received travel reimbursement from the Sleep Research Society, the National Sleep Foundation, the Santa Fe Institute, the World Conference of Chronobiology, the Gordon Research Conference, and the German Sleep Society (DGSM); she was paid by the Puerto Rico Trust for a grant review, and has consulted for the American Academy of Sleep Medicine Foundation, Circadian Therapeutics, the National Sleep Foundation, Sanofi-Genzyme, and Yale University Press. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Grant Information: | R01 HL128538 United States HL NHLBI NIH HHS; R01 HD107064 United States HD NICHD NIH HHS; P01 AG009975 United States AG NIA NIH HHS; R01 HL114088 United States HL NHLBI NIH HHS; R01 HL103607 United States HL NHLBI NIH HHS |
| Contributed Indexing: | Keywords: circadian misalignment; circadian rhythms; shift-work; sleep restriction; sleep timing |
| Entry Date(s): | Date Created: 20220725 Latest Revision: 20221213 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9305384 |
| DOI: | 10.3389/fphys.2022.914497 |
| PMID: | 35874530 |
| Database: | MEDLINE |
Journal Article