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Efficacy of Acupuncture, Intravenous Lidocaine, and Diet in the Management of Patients with Fibromyalgia: A Systematic Review and Network Meta-Analysis.

Title: Efficacy of Acupuncture, Intravenous Lidocaine, and Diet in the Management of Patients with Fibromyalgia: A Systematic Review and Network Meta-Analysis.
Authors: Almutairi NM; Department of Anesthesia and Pain Management, Security Forces Hospital, Riyadh 11481, Saudi Arabia.; Hilal FM; Saudi Board of Anesthesia SPA, Ministry of Health, King Fahad General Hospital, Jeddah 23325, Saudi Arabia.; Bashawyah A; Department of Anesthesiology, College of Medicine, King Abdulaziz University Hospital, Jeddah 22252, Saudi Arabia.; Dammas FA; Department of Anesthesia and Pain Management, King Khalid University Hospital and Medical City, Riyadh 61421, Saudi Arabia.; Yamak Altinpulluk E; MoMaRC Morphological Madrid Research Center, 28029 Madrid, Spain.; Department of Outcomes Research Consortium, Cleveland Clinic, Cleveland, OH 44195, USA.; Anesthesiology Clinical Research Office, Ataturk University, 25030 Erzurum, Turkey.; Hou JD; Division of Anesthesiology, Hualien Armed Forces General Hospital, Hualien 97144, Taiwan.; Department of Anesthesiology, School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.; Lin JA; Department of Anesthesiology, School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.; Center for Regional Anesthesia and Pain Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Pain Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, No. 111, Sec. 3, Xinglong Rd., Wenshan Dist., Taipei City 116, Taiwan.; Department of Anesthesiology, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Anesthesiology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.; Varrassi G; Paolo Procacci Foundation, 00193 Roma, Italy.; Chang KV; Center for Regional Anesthesia and Pain Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch 10845, Taiwan.; Allam AE; MoMaRC Morphological Madrid Research Center, 28029 Madrid, Spain.; Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Source: Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2022 Jun 23; Vol. 10 (7). Date of Electronic Publication: 2022 Jun 23.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101666525 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9032 (Print) Linking ISSN: 22279032 NLM ISO Abbreviation: Healthcare (Basel) Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI AG, [2013]-
Abstract: Introduction: This network meta-analysis aimed to assess the efficacy of acupuncture, intravenous lidocaine, and diet compared with other comparators such as physiotherapy and sham/placebo in fibromyalgia patients. Materials and Methods: We searched Embase, PubMed, Scopus, and Web of Science for relevant studies till September 2021. The included studies were randomized controlled clinical trials. For the network meta-analysis, we used the R software. Results: There were 23 included RCTs. The total sample size was 1409 patients. Compared with the sham/placebo group, the network analysis showed the highest improvement in the quality of life in the acupuncture group standardized mean difference (SMD) = -10.28, 95%-CI [-14.96; -5.59]), and then in the physiotherapy group (SMD = -7.48, 95%-CI [-14.72; -0.23]). For the pain, there was a significant reduction with acupuncture (SMD = -1.69, 95%-CI [-2.48; -0.89]), compared with sham/placebo. Regarding depression, it showed a significant reduction with acupuncture (SMD = -9.64, 95%-CI [-16.13; -3.14]) compared with sham/placebo. Finally, for stiffness, it showed no significant differences in the stiffness between acupuncture (SMD = -8.52, 95%-CI [-20.40; 3.36]), fluoxetine (SMD = -6.52, 95%-CI [-29.65; 16.61]), and physiotherapy (SMD = -4.64, 95%-CI [-22.83; 13.54]) compared with sham/placebo. Conclusions: The acupuncture showed a significant effect in the management of fibromyalgia patients. It reduced pain, depression, and enhanced the quality of life. While physiotherapy showed a significant improvement in the quality of life only. In contrast, intravenous lidocaine and diet showed no significant differences when compared with sham/placebo.
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Grant Information: HAFGH_A_111002 Hualien Armed Forces General Hospital, Taiwan
Contributed Indexing: Keywords: acupuncture; diet; fibromyalgia; lidocaine; network meta-analysis
Entry Date(s): Date Created: 20220727 Latest Revision: 20220731
Update Code: 20260130
PubMed Central ID: PMC9320380
DOI: 10.3390/healthcare10071176
PMID: 35885703
Database: MEDLINE

Journal Article