Design, Characterization, and Antibacterial Performance of MAPLE-Deposited Coatings of Magnesium Phosphate-Containing Silver Nanoparticles in Biocompatible Concentrations.
| Title: | Design, Characterization, and Antibacterial Performance of MAPLE-Deposited Coatings of Magnesium Phosphate-Containing Silver Nanoparticles in Biocompatible Concentrations. |
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| Authors: | Florea DA; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Grumezescu V; National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania.; Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Vasile BȘ; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Mușat M; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Stan MS; Research Institute of the University of Bucharest (ICUB), University of Bucharest, 050657 Bucharest, Romania.; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest (ICUB), University of Bucharest, 050657 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Chifiriuc MC; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Department of Microbiology, Faculty of Biology, University of Bucharest, Aleea Portocalelor Str. 1-3, District 5, 060101 Bucharest, Romania.; The Romanian Academy, Calea Victoriei 25, District 1, 010071 Bucharest, Romania. |
| Source: | International journal of molecular sciences [Int J Mol Sci] 2022 Jul 18; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 18. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2000- |
| MeSH Terms: | Metal Nanoparticles*/chemistry ; Acer*; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Silver/chemistry ; Silver/pharmacology ; Female ; Humans ; Magnesium Compounds ; Microbial Sensitivity Tests ; Phosphates ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction |
| Abstract: | Bone disorders and traumas represent a common type of healthcare emergency affecting men and women worldwide. Since most of these diseases imply surgery, frequently complicated by exogenous or endogenous infections, there is an acute need for improving their therapeutic approaches, particularly in clinical conditions requiring orthopedic implants. Various biomaterials have been investigated in the last decades for their potential to increase bone regeneration and prevent orthopedic infections. The present study aimed to develop a series of MAPLE-deposited coatings composed of magnesium phosphate (Mg3(PO4)2) and silver nanoparticles (AgNPs) designed to ensure osteoblast proliferation and anti-infective properties simultaneously. Mg3(PO4)2 and AgNPs were obtained through the cooling bath reaction and chemical reduction, respectively, and then characterized through X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Selected Area Electron Diffraction (SAED). Subsequently, the obtained coatings were evaluated by Infrared Microscopy (IRM), Fourier-Transform Infrared Spectroscopy (FT-IR), and Scanning Electron Microscopy (SEM). Their biological properties show that the proposed composite coatings exhibit well-balanced biocompatibility and antibacterial activity, promoting osteoblasts viability and proliferation and inhibiting the adherence and growth of Staphylococcus aureus and Pseudomonas aeruginosa, two of the most important agents of orthopedic implant-associated infections. |
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| Contributed Indexing: | Keywords: MAPLE; Ps. aeruginosa; S. aureus; biofilms; magnesium phosphate; osteoblasts; silver nanoparticles |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents); 0 (Magnesium Compounds); 0 (Phosphates); 3M4G523W1G (Silver); 453COF7817 (magnesium phosphate) |
| Entry Date(s): | Date Created: 20220727 Date Completed: 20220728 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9321465 |
| DOI: | 10.3390/ijms23147910 |
| PMID: | 35887261 |
| Database: | MEDLINE |
Journal Article