First Report of a Complete Genome Sequence of a Variant African Swine Fever Virus in the Mekong Delta, Vietnam.
| Title: | First Report of a Complete Genome Sequence of a Variant African Swine Fever Virus in the Mekong Delta, Vietnam. |
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| Authors: | Hien ND; Department of Veterinary Medicine, College of Agriculture, Can Tho University, Campus II, 3/2 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Can Tho Sub-Department of Animal Health, Ministry of Agriculture and Rural Development, 30/4 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Nguyen LT; Department of Veterinary Medicine, College of Agriculture, Can Tho University, Campus II, 3/2 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Hoang LT; Department of Veterinary Medicine, College of Agriculture, Can Tho University, Campus II, 3/2 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Can Tho Sub-Department of Animal Health, Ministry of Agriculture and Rural Development, 30/4 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Bich NN; Department of Veterinary Medicine, College of Agriculture, Can Tho University, Campus II, 3/2 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Quyen TM; Department of Veterinary Medicine, College of Agriculture, Can Tho University, Campus II, 3/2 Street, Ninh Kieu District, Can Tho 900000, Vietnam.; Isoda N; Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, Sapporo 060-0818, Hokkaido, Japan.; Sakoda Y; Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, Sapporo 060-0818, Hokkaido, Japan. |
| Source: | Pathogens (Basel, Switzerland) [Pathogens] 2022 Jul 15; Vol. 11 (7). Date of Electronic Publication: 2022 Jul 15. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
| Abstract: | The objective of this study is to report the complete-genome sequence of a field African swine fever (ASF) virus (ASFV), namely ASF/VN/CanTho-OM/2021, which caused a fatal outbreak in domestic pigs in the Mekong Delta. Complete-genome sequencing detected an 18 bp nucleotide deletion in the EP402R gene (encoding for serotype-specific proteins CD2v) of ASF/VN/CanTho-OM/2021, which was determined to belong to genotype 2 and serotype 8. This mutation pattern was confirmed as unique in GenBank; thus, ASF/VN/CanTho-OM/2021 can be considered a novel variant, with a potential change of sero-characteristics within genotype 2. An additional unique mutation of 78 bp nucleotide insertion was also observed in the B475L gene. Additionally, four copies of tandem repeat sequences were found in the intergenic region (IGR) located between I73R and I329L, previously assigned as the IGR III variant. This study is the first to report the complete genome of ASFV in the Mekong Delta, and it highlights the necessity of strengthening molecular surveillance to provide further knowledge on the evolution and incursion of ASFV in the Mekong Delta and Vietnam. |
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| Contributed Indexing: | Keywords: African swine fever; Mekong Delta; Vietnam; complete genome; variant |
| Entry Date(s): | Date Created: 20220727 Latest Revision: 20220731 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9318516 |
| DOI: | 10.3390/pathogens11070797 |
| PMID: | 35890041 |
| Database: | MEDLINE |
Journal Article