High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021.
| Title: | High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021. |
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| Authors: | Iwamoto C; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.; Lesteberg KE; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.; Lamb MM; Department of Epidemiology and Center for Global Health, Colorado School of Public Health, 13199 E. Montview Blvd, Aurora, CO 80045, USA.; Calvimontes DM; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; La Comisión Presidencial de Atención a la Emergencia COVID-19 (Coprecovid), Guatemala City 01010, Guatemala.; Guo K; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.; Barrett BS; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.; Mickens KL; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.; Duca LM; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.; Monzon J; Centers for Disease Control and Prevention, Division of Global Health Protection (CDC-DGHP), 1600 Clifton Rd., Atlanta, GA 30329, USA.; Chard AN; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.; Guzman G; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Barrios E; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Rojop N; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Arias K; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Gomez M; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Paiz C; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Bolanos GA; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Edwards KM; Division of Infectious Disease, Department of Pediatrics, Vanderbilt University School of Medicine, 2200 Children's Way, 6th Floor, Nashville, TN 37232, USA.; Zielinski Gutierrez E; Centers for Disease Control and Prevention, Division of Global Health Protection (CDC-DGHP), 1600 Clifton Rd., Atlanta, GA 30329, USA.; Azziz-Baumgartner E; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.; Asturias EJ; Department of Epidemiology and Center for Global Health, Colorado School of Public Health, 13199 E. Montview Blvd, Aurora, CO 80045, USA.; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; La Comisión Presidencial de Atención a la Emergencia COVID-19 (Coprecovid), Guatemala City 01010, Guatemala.; Division of Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine, 13123 E. 16th Ave., Aurora, CO 80045, USA.; Santiago ML; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.; Beckham JD; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.; Olson D; Department of Epidemiology and Center for Global Health, Colorado School of Public Health, 13199 E. Montview Blvd, Aurora, CO 80045, USA.; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.; Division of Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine, 13123 E. 16th Ave., Aurora, CO 80045, USA. |
| Source: | Vaccines [Vaccines (Basel)] 2022 Jul 21; Vol. 10 (7). Date of Electronic Publication: 2022 Jul 21. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG |
| Abstract: | Essential agricultural workers work under occupational conditions that may increase the risk of SARS-CoV-2 exposure and transmission. Data from an agricultural worker cohort in Guatemala, and anti-SARS-CoV-2 nucleocapsid IgG (anti-N IgG) testing were used to estimate past infections and analyze risk factors associated with seropositivity at enrollment and association with SARS-CoV-2 infection. The stability of neutralizing antibody (NAb) responses were assessed in a subset of participants. The adjusted relative risk (aRR) for seroprevalence at enrollment was estimated accounting for correlations within worksites. At enrollment, 616 (46.2%) of 1334 (93.2%) participants had anti-N IgG results indicating prior SARS-CoV-2 infection. A cough ≤ 10 days prior to enrollment (aRR = 1.28, 95% CI: 1.13−1.46) and working as a packer (aRR = 2.00, 95% CI: 1.67−2.38) or packing manager within the plants (aRR = 1.82, 95% CI: 1.36−2.43) were associated with increased risk of seropositivity. COVID-19 incidence density among seronegative workers was 2.3/100 Person-Years (P-Y), higher than seropositive workers (0.4/100 P-Y). Most workers with follow-up NAb testing (65/77, 84%) exhibited a 95% average decrease in NAb titers in |
| References: | Nature. 2020 Mar;579(7798):270-273. (PMID: 32015507); Cell Rep Med. 2021 Apr 20;2(4):100253. (PMID: 33842901); JAMA Netw Open. 2021 Sep 1;4(9):e2124116. (PMID: 34524438); Nat Med. 2020 Aug;26(8):1200-1204. (PMID: 32555424); PLoS One. 2021 Apr 27;16(4):e0250495. (PMID: 33905442); J Immigr Minor Health. 2022 Feb;24(1):58-64. (PMID: 34637039); Am J Public Health. 2022 Jan;112(1):38-42. (PMID: 34936397); Am J Epidemiol. 2011 Oct 15;174(8):984-92. (PMID: 21841157); Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203760119. (PMID: 35867811); JAMA. 2020 Jun 9;323(22):2249-2251. (PMID: 32374370); Clin Infect Dis. 2021 Nov 2;73(9):e3066-e3073. (PMID: 33147319); Sci Adv. 2021 Jul 30;7(31):. (PMID: 34330709); Ann Intern Med. 2021 May;174(5):655-662. (PMID: 33481642); Emerg Infect Dis. 2022;28(13):S277-S287. (PMID: 36502430); BMJ. 2022 Mar 9;376:e069761. (PMID: 35264324); PLoS Med. 2021 Jul 6;18(7):e1003656. (PMID: 34228725); J Exp Med. 2020 Nov 2;217(11):. (PMID: 32692348); Front Public Health. 2021 Oct 27;9:769238. (PMID: 34778195); Emerg Infect Dis. 2021 May;27(5):1330-1342. (PMID: 33657340); MMWR Morb Mortal Wkly Rep. 2020 May 08;69(18):. (PMID: 32379731); mBio. 2021 Aug 31;12(4):e0150321. (PMID: 34311582); J Clin Microbiol. 2020 Sep 22;58(10):. (PMID: 32747400); Lancet Microbe. 2021 Jun;2(6):e240-e249. (PMID: 33778792); JAMA Netw Open. 2021 Jan 4;4(1):e2035057. (PMID: 33410879); PLoS One. 2020 Mar 6;15(3):e0229413. (PMID: 32142520); JAMA Intern Med. 2020 Jul 21;:. (PMID: 32692365); MMWR Morb Mortal Wkly Rep. 2021 Aug 13;70(32):1081-1083. (PMID: 34383732); Agric Econ. 2021 May;52(3):477-494. (PMID: 34149131); J Gen Virol. 2021 Oct;102(10):. (PMID: 34623233); Ann Intern Med. 2022 Apr;175(4):547-555. (PMID: 35073157); Clin Infect Dis. 2022 Aug 24;75(1):e827-e837. (PMID: 34928334); Am J Epidemiol. 1994 Jun 1;139(11):1055-65. (PMID: 8192138); PLoS One. 2021 Apr 28;16(4):e0250621. (PMID: 33909685); PLoS One. 2021 Jun 4;16(6):e0252454. (PMID: 34086762); BMC Public Health. 2022 Jan 24;22(1):162. (PMID: 35073884); Science. 2020 Dec 4;370(6521):1227-1230. (PMID: 33115920); MMWR Morb Mortal Wkly Rep. 2021 Apr 30;70(17):617-621. (PMID: 33914719); Am J Epidemiol. 2004 Apr 1;159(7):702-6. (PMID: 15033648); Nat Med. 2021 Jul;27(7):1205-1211. (PMID: 34002089); Science. 2021 Feb 5;371(6529):. (PMID: 33408181); J Clin Invest. 2021 Sep 1;131(17):. (PMID: 34623327); N Engl J Med. 2021 Apr 8;384(14):1372-1374. (PMID: 33691060); EMBO Mol Med. 2020 Dec 7;12(12):e13296. (PMID: 33012091) |
| Grant Information: | I01 BX003863 United States BX BLRD VA; K23 AI143967 United States AI NIAID NIH HHS; R01 AI153724 United States AI NIAID NIH HHS |
| Contributed Indexing: | Keywords: COVID-19; Guatemala; SARS-CoV-2; agricultural workers; cohort; seroprevalence |
| Entry Date(s): | Date Created: 20220727 Latest Revision: 20241127 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9323551 |
| DOI: | 10.3390/vaccines10071160 |
| PMID: | 35891324 |
| Database: | MEDLINE |
Journal Article