Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry.
| Title: | Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry. |
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| Authors: | De Luca G; Division of Clinical and Experimental Cardiology, AOU Sassari, Sassari, Italy. gdeluca@uniss.it.; University of Sassari, Sassari, Italy. gdeluca@uniss.it.; Nardin M; Third Medicine Division, ASST Spedali Civili, Brescia, Italy.; Algowhary M; Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut, Egypt.; Uguz B; Division of Cardiology, Bursa City Hospital, Bursa, Turkey.; Oliveira DC; Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife, Brazil.; Ganyukov V; Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.; Zimbakov Z; Medical Faculty, University Clinic for Cardiology, Ss' Cyril and Methodius University, Skopje, North Macedonia.; Cercek M; Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, Slovenia.; Okkels Jensen L; Division of Cardiology, Odense Universitets Hospital, Odense, Danemark.; Loh PH; Department of Cardiology, National University Hospital, Singapore, Singapore.; Calmac L; Clinic Emergency Hospital of Bucharest, Bucharest, Romania.; Roura Ferrer G; Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, Barcelona, Spain.; Quadros A; Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, Brazil.; Milewski M; Division of Cardiology, Medical University of Silezia, Katowice, Poland.; Scotto di Uccio F; Division of Cardiology, Ospedale del Mare, Naples, Italy.; von Birgelen C; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Enschede, The Netherlands.; Versaci F; Division of Cardiology, Ospedale Santa Maria Goretti Latina, Latina, Italy.; Ten Berg J; Division of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.; Casella G; Division of Cardiology, Ospedale Maggiore Bologna, Bologna, Italy.; Wong Sung Lung A; Department of Cardiology, National Heart Center, Singapore, Singapore.; Kala P; University Hospital Brno, Medical Faculty of Masaryk University, Brno, Czech Republic.; Díez Gil JL; H. Universitario y Politécnico La Fe, Valencia, Spain.; Carrillo X; Hospital Germans Triasi Pujol, Badalona, Spain.; Dirksen M; Division of Cardiology, Northwest Clinics, Alkmaar, The Netherlands.; Becerra-Munoz VM; Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.; Lee MK; Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Yau Ma Tei, Hong Kong.; Arifa Juzar D; Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center 'Harapan Kita', Jakarta, Indonesia.; de Moura Joaquim R; Instituto de Cardiologia de Santa Catarina Praia Comprida, São José, Brasil.; Paladino R; Division of Cardiology, Clinica Villa dei Fiori, Acerra, Italy.; Milicic D; Department of Cardiology, University Hospital Centre, University of Zagreb, Zagreb, Croatia.; Davlouros P; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, Greece.; Bakraceski N; Center for Cardiovascular Diseases, Ohrid, North Macedonia.; Zilio F; Division of Cardiology, Ospedale Santa Chiara di Trento, Trento, Italy.; Donazzan L; Division of Cardiology, Ospedale 'S. Maurizio' Bolzano, Bolzano, Italy.; Kraaijeveld A; Division of Cardiology, UMC Utrecht, Utrecht, The Netherlands.; Galasso G; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.; Lux A; Maastricht University Medical Center, Maastricht, The Netherlands.; Marinucci L; Division of Cardiology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Pesaro, Italy.; Guiducci V; Division of Cardiology, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy.; Menichelli M; Division of Cardiology, Ospedale 'F. Spaziani', Frosinone, Italy.; Scoccia A; Division of Cardiology, Ospedale 'Sant'Anna', Ferrara, Italy.; Yamac AH; Department of Cardiology, Hospital Bezmialem Vakıf University, İstanbul, Turkey.; Ugur Mert K; Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.; Flores Rios X; Complexo Hospetaliero Universitario La Coruna, La Coruna, Spain.; Kovarnik T; University Hospital Prague, Prague, Czech Republic.; Kidawa M; Central Hospital of Medical University of Lodz, Lodz, Poland.; Moreu J; Division of Cardiology, Complejo Hospitalario de Toledo, Toledo, Spain.; Flavien V; Division of Cardiology, Center Hospitalier Universitaire de Lille, Lille, France.; Fabris E; Azienda Ospedaliero-Universitaria Ospedali Riuniti Trieste, Trieste, Italy.; Martínez-Luengas IL; Division of Cardiology, Hospital Cabueñes, Gijon, Spain.; Boccalatte M; Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Italy.; Bosa Ojeda F; Division of Cardiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.; Arellano-Serrano C; Division of Cardiology, Hospital Puerta de Hierro Majadahonda, Madrid, Spain.; Caiazzo G; Division of Cardiology, Ospedale 'G Moscati', Aversa, Italy.; Cirrincione G; Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.; Kao HL; Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, Tapei, Taiwan.; Sanchis Forés J; Division of Cardiology, Hospital Clinico Universitario de Valencia, Valencia, Spain.; Vignali L; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy.; Pereira H; Cardiology Department, Hospital Garcia de Orta, Pragal, Almada, Portugal.; Manzo S; Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, Paris, France.; Ordoñez S; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Özkan AA; Cardiology Institute, Istanbul University, Istanbul, Turkey.; Scheller B; Division of Cardiology Clinical and Experimental Interventional Cardiology, University of Saarland, Saarbrücken, Germany.; Lehtola H; Division of Cardiology, Oulu University Hospital, Oulu, Finland.; Teles R; Division of Cardiology, Hospital de Santa Cruz, CHLO-Nova Medical School, CEDOC, Lisbon, Portugal.; Mantis C; Division of Cardiology, Kontantopoulion Hospital, Athens, Greece.; Antti Y; Division of Cardiology, Heart Centre Turku, Turku, Finland.; Brum Silveira JA; Division of Cardiology, Hospital de Santo António, Porto, Portugal.; Zoni R; Department of Teaching and Research, Instituto de Cardiología de Corrientes 'Juana F. Cabral', Corrientes, Argentina.; Bessonov I; Tyumen Cardiology Research Center, Tyumen, Russia.; Savonitto S; Division of Cardiology, Ospedale 'A. Manzoni', Lecco, Italy.; Kochiadakis G; Iraklion University Hospital, Crete, Greece.; Alexopoulos D; Division of Cardiology, Attikon University Hospital, Athens, Greece.; Uribe CE; Division of Cardiology, Universidad UPB, Universidad CES, Medellin, Colombia.; Kanakakis J; Division of Cardiology, Alexandra Hospital, Athens, Greece.; Faurie B; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France.; Gabrielli G; Interventional Cardiology Unit, Azienda Ospedaliero Universitaria'Ospedali Riuniti', Ancona, Italy.; Gutierrez Barrios A; Division of Cardiology, Hospital Puerta del Mar, Cadiz, Spain.; Bachini JP; Instituto de Cardiologia Integral, Montevideo, Uruguay.; Rocha A; Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo, Uruguay.; Tam FC; Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong.; Rodriguez A; Division of Cardiology, Otamendi Hospital, Buenos Aires, Argentina.; Lukito AA; Cardiovascular Department Pelita, Harapan University/Heart Center Siloam Lippo Village Hospital, Tangerang, Banten, Indonesia.; Saint-Joy V; Center Hospitalier d'Antibes Juan Les Pins, Antibes, France.; Pessah G; Division of Cardiology, Hospiatl Cordoba, Cordoba, Argentina.; Tuccillo A; Division of Cardiology, Ospedale del Mare, Naples, Italy.; Cortese G; Department of Statistical Sciences, University of Padova, Padua, Italy.; Parodi G; Department of Cardiology, ASL 4 Liguria, Lavagna, Italy.; Bouraghda MA; Division of Cardiology, Blida University Hospital, Blida, Algeria.; Kedhi E; Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, Brussels, Belgium.; Lamelas P; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Suryapranata H; Division of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.; Verdoia M; Division of Cardiology, Ospedale degli Infermi, ASL Biella, Ponderano, Italy. |
| Source: | Respiratory research [Respir Res] 2022 Aug 15; Vol. 23 (1), pp. 207. Date of Electronic Publication: 2022 Aug 15. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : London : BioMed Central Ltd.; Original Publication: London : Current Science Ltd., c2000- |
| MeSH Terms: | COVID-19*/epidemiology ; Percutaneous Coronary Intervention*/adverse effects ; Pulmonary Disease, Chronic Obstructive*/diagnosis ; Pulmonary Disease, Chronic Obstructive*/epidemiology ; Pulmonary Disease, Chronic Obstructive*/therapy ; ST Elevation Myocardial Infarction*/diagnosis ; ST Elevation Myocardial Infarction*/epidemiology ; ST Elevation Myocardial Infarction*/therapy; Aged ; Hospital Mortality ; Humans ; Pandemics ; Registries ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome |
| Abstract: | Background: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study.; Methods: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents.; Results: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups.; Conclusion: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity.; Trial Registration Number: NCT04412655 (2nd June 2020).; (© 2022. The Author(s).) |
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| Contributed Indexing: | Keywords: COPD; Mortality; STEMI |
| Molecular Sequence: | ClinicalTrials.gov NCT04412655 |
| Entry Date(s): | Date Created: 20220815 Date Completed: 20220817 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9376902 |
| DOI: | 10.1186/s12931-022-02128-0 |
| PMID: | 35971173 |
| Database: | MEDLINE |
Journal Article; Multicenter Study