The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.
| Title: | The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes. |
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| Authors: | Magge SN; Division of Pediatric Endocrinology and Diabetes, Johns Hopkins Hospital/Johns Hopkins University School of Medicine, Baltimore, MD.; Wolf RM; Division of Pediatric Endocrinology and Diabetes, Johns Hopkins Hospital/Johns Hopkins University School of Medicine, Baltimore, MD.; Pyle L; Department of Pediatrics, University of Colorado Anschutz Medical Campus/Children's Hospital Colorado, Aurora, CO.; Brown EA; Division of Pediatric Endocrinology and Diabetes, Johns Hopkins Hospital/Johns Hopkins University School of Medicine, Baltimore, MD.; Benavides VC; Department of Pediatrics, Division of Endocrinology, University of Illinois, College of Medicine of Peoria/Children's Hospital of Illinois, Peoria, IL.; Bianco ME; Department of Pediatrics, Division of Pediatric Endocrinology, Northwestern University/Ann and Robert H Lurie Children's Hospital, Chicago, IL.; Chao LC; Center for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA.; Cymbaluk A; Department of Pediatric Diabetes and Endocrinology, Texas Children's Hospital/Baylor College of Medicine, Houston, TX.; Balikcioglu PG; Division of Pediatric Endocrinology and Diabetes and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC.; Halpin K; Division of Endocrinology and Diabetes, University of Missouri-Kansas City School of Medicine, Children's Mercy Kansas City, Kansas City, MO.; Hsia DS; Our Lady of the Lake Children's Hospital/Pennington Biomedical Research Center, Baton Rouge, LA.; Huerta-Saenz L; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Penn State Health Children's Hospital/Penn State College of Medicine, Hershey, PA.; Kim JJ; Department of Pediatrics, Division of Pediatric Endocrinology, University of California San Diego/Rady Children's Hospital San Diego, San Diego, CA.; Kumar S; Department of Pediatrics, Division of Pediatric Endocrinology, Mayo Clinic, Rochester, MN.; Levitt Katz LE; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA.; Marks BE; Division of Endocrinology and Diabetes, Children's National Hospital, Washington DC.; Neyman A; Department of Pediatrics, Indiana University School of Medicine/Riley Hospital for Children, Indianapolis, IN.; O'Sullivan KL; Section of Adult & Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago Medical Center, Chicago, IL.; Pillai SS; Division of Pediatric Endocrinology, Warren Alpert Medical School of Brown University/Hasbro Children's Hospital, Providence, RI.; Shah AS; Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center & The University of Cincinnati, Cincinnati, OH.; Shoemaker AH; Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, TN.; Siddiqui JAW; Department of Pediatrics, Columbia University Irving Medical Center, Harlem Hospital, New York, NY.; Srinivasan S; Department of Pediatrics, Division of Endocrinology, University of California, San Francisco, San Francisco, CA.; Thomas IH; Department of Pediatrics, Pediatric Endocrinology, University of Michigan, Ann Arbor, MI.; Tryggestad JB; Department of Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.; Yousif MF; Department of Pediatrics, Pediatric Endocrinology, University of Texas Southwestern, Dallas, TX.; Kelsey MM; Department of Pediatrics, University of Colorado Anschutz Medical Campus/Children's Hospital Colorado, Aurora, CO. Electronic address: megan.kelsey@childrenscolorado.org. |
| Corporate Authors: | COVID-19 and Type 2 Diabetes Consortium |
| Source: | The Journal of pediatrics [J Pediatr] 2022 Dec; Vol. 251, pp. 51-59.e2. Date of Electronic Publication: 2022 Aug 17. |
| Publication Type: | Multicenter Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Mosby Country of Publication: United States NLM ID: 0375410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6833 (Electronic) Linking ISSN: 00223476 NLM ISO Abbreviation: J Pediatr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: St. Louis, MO : Mosby |
| MeSH Terms: | COVID-19*/epidemiology ; Diabetes Mellitus, Type 1*/diagnosis ; Diabetes Mellitus, Type 1*/epidemiology ; Diabetes Mellitus, Type 1*/complications ; Diabetes Mellitus, Type 2*/epidemiology ; Diabetes Mellitus, Type 2*/complications ; Diabetic Ketoacidosis*/complications; Child ; Adolescent ; Humans ; Female ; Male ; Pandemics ; Retrospective Studies |
| Abstract: | Objectives: To evaluate the frequency and severity of new cases of youth-onset type 2 diabetes in the US during the first year of the pandemic compared with the mean of the previous 2 years.; Study Design: Multicenter (n = 24 centers), hospital-based, retrospective chart review. Youth aged ≤21 years with newly diagnosed type 2 diabetes between March 2018 and February 2021, body mass index ≥85th percentile, and negative pancreatic autoantibodies were included. Demographic and clinical data, including case numbers and frequency of metabolic decompensation, were compared between groups.; Results: A total of 3113 youth (mean [SD] 14.4 [2.4] years, 50.5% female, 40.4% Hispanic, 32.7% Black, 14.5% non-Hispanic White) were assessed. New cases of type 2 diabetes increased by 77.2% in the year during the pandemic (n = 1463) compared with the mean of the previous 2 years, 2019 (n = 886) and 2018 (n = 765). The likelihood of presenting with metabolic decompensation and severe diabetic ketoacidosis also increased significantly during the pandemic.; Conclusions: The burden of newly diagnosed youth-onset type 2 diabetes increased significantly during the coronavirus disease 2019 pandemic, resulting in enormous strain on pediatric diabetes health care providers, patients, and families. Whether the increase was caused by coronavirus disease 2019 infection, or just associated with environmental changes and stressors during the pandemic is unclear. Further studies are needed to determine whether this rise is limited to the US and whether it will persist over time.; (Copyright © 2022 Elsevier Inc. All rights reserved.) |
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| Grant Information: | P30 DK048520 United States DK NIDDK NIH HHS; P30 DK116073 United States DK NIDDK NIH HHS; T32 DK007161 United States DK NIDDK NIH HHS; K23 DK110539 United States DK NIDDK NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; K23 DK129827 United States DK NIDDK NIH HHS |
| Entry Date(s): | Date Created: 20220819 Date Completed: 20221206 Latest Revision: 20240328 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9383958 |
| DOI: | 10.1016/j.jpeds.2022.08.010 |
| PMID: | 35985535 |
| Database: | MEDLINE |
Multicenter Study; Journal Article