Angiosarcomas of the head and neck: Impact of large data analysis on clinical management.
| Title: | Angiosarcomas of the head and neck: Impact of large data analysis on clinical management. |
|---|---|
| Authors: | Wreesmann VB; Hospital Nostra Senyora de Meritxell, Carrer dels Escalls, Escaldes-Engordany, Andorra.; Department of Otolaryngology-Head and Neck Surgery, Oxford University Hospitals, Oxford, UK.; Clinica Omega Zeta Andorra, Andorra la Vella, Andorra.; Oomen KP; Clinica Omega Zeta Andorra, Andorra la Vella, Andorra.; Brennan PA; Department of Oral and Maxillofacial Surgery, Portsmouth Hospitals University NHS Trust, Portsmouth, UK. |
| Source: | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2022 Nov; Vol. 51 (10), pp. 904-910. Date of Electronic Publication: 2022 Sep 20. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8911934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0714 (Electronic) Linking ISSN: 09042512 NLM ISO Abbreviation: J Oral Pathol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford, UK : Wiley-Blackwell; Original Publication: Copenhagen : Munksgaard, c1989- |
| MeSH Terms: | Hemangiosarcoma*/therapy ; Hemangiosarcoma*/diagnosis ; Hemangiosarcoma*/pathology ; Head and Neck Neoplasms*/diagnosis ; Head and Neck Neoplasms*/pathology ; Head and Neck Neoplasms*/therapy ; Sarcoma*; Neck/pathology ; Humans ; Data Analysis ; Prognosis |
| Abstract: | Angiosarcoma is a rare but often fatal malignancy from blood and lymphatic vessels that can arise anywhere in the body and often affects the head and neck region. Although its dismal prognosis is predominantly explained by its aggressive biology, several secondary factors contribute to poor outcomes. These include a phenotypic resemblance to innocuous blood vessel lesions, which contributes to a significant degree of late diagnosis. Another important factor is the rarity of angiosarcoma, which has impaired scientific determination of its optimal treatment significantly. As a result, treatment of angiosarcomas has largely been guided by information derived from the study of sarcomas at large, themselves a highly heterogeneous group of mesenchymal cancers both from a diagnostic as well as therapeutical perspective. The Digital Revolution and resultant Information Age promise to transform the clinical management of rare cancers from a generic to a more customized approach. In this paper, we review the current understanding of head and neck angiosarcomas within the context of this process.; (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| Contributed Indexing: | Keywords: angiosarcoma; head and neck; outcomes; review |
| Entry Date(s): | Date Created: 20220906 Date Completed: 20221208 Latest Revision: 20221208 |
| Update Code: | 20260130 |
| DOI: | 10.1111/jop.13354 |
| PMID: | 36066314 |
| Database: | MEDLINE |
Journal Article; Review