Serotonin Syndrome After Treatment of Nausea and Vomiting in Pregnancy.
| Title: | Serotonin Syndrome After Treatment of Nausea and Vomiting in Pregnancy. |
|---|---|
| Authors: | Wiseman D; Department of Medicine, the Department of Critical Care Medicine, and the Department of Neurology, McGill University Health Centre, and the Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada .; Samoukovic G; Durcan L; Malhamé I |
| Source: | Obstetrics and gynecology [Obstet Gynecol] 2022 Oct 01; Vol. 140 (4), pp. 696-699. Date of Electronic Publication: 2022 Sep 07. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401101 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-233X (Electronic) Linking ISSN: 00297844 NLM ISO Abbreviation: Obstet Gynecol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2004- : Hagerstown, MD : Lippincott Williams & Wilkins; Original Publication: New York. |
| MeSH Terms: | Serotonin Syndrome*/therapy ; Serotonin Syndrome*/drug therapy ; Antiemetics*/therapeutic use ; Hyperemesis Gravidarum*/drug therapy ; Hyperemesis Gravidarum*/diagnosis ; COVID-19 Drug Treatment*; Nausea/drug therapy ; Nausea/etiology ; Vomiting/drug therapy ; Vomiting/etiology ; Pregnancy ; Female ; Humans ; Adult ; SARS-CoV-2 |
| Abstract: | Background: Nausea and vomiting in pregnancy often require pharmacotherapy for symptom management. Serotonin syndrome is a rare clinical entity that can be precipitated by the medications used to treat nausea and vomiting in pregnancy.; Case: A 35-year-old pregnant individual with a history of hyperemesis gravidarum in an earlier pregnancy requiring prolonged hospitalization presented with nausea and vomiting at 7 weeks of gestation. She was incidentally found to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection when she was universally screened at the time of admission. She required pharmacotherapy, including prochlorperazine and ondansetron for treatment of nausea as well as sumatriptan for migraine. She developed acute spasticity, autonomic dysfunction, and temperature rise, precipitated by antiemetic therapy, consistent with serotonin syndrome. The syndrome resolved with supportive care and benzodiazepines.; Conclusion: Serotonin syndrome is a serious clinical entity that can be provoked by the pharmacotherapy given to treat nausea and vomiting in pregnancy. This medical emergency requires early recognition and prompt management.; (Copyright © 2022 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.) |
| Competing Interests: | Financial Disclosure The authors did not report any potential conflicts of interest. |
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| Substance Nomenclature: | 0 (Antiemetics) |
| Entry Date(s): | Date Created: 20220908 Date Completed: 20221114 Latest Revision: 20230103 |
| Update Code: | 20260130 |
| DOI: | 10.1097/AOG.0000000000004941 |
| PMID: | 36075069 |
| Database: | MEDLINE |
Journal Article