A Comparative Loading and Release Study of Vancomycin from a Green Mesoporous Silica.
| Title: | A Comparative Loading and Release Study of Vancomycin from a Green Mesoporous Silica. |
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| Authors: | Dolete G; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Purcăreanu B; BIOTEHNOS SA, Gorunului Street 3-5, 075100 Otopeni, Romania.; Mihaiescu DE; Department of Organic Chemistry 'Costin Nenițescu', Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; Ficai D; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry, and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; Oprea OC; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry, and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania.; Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Vasile BȘ; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Vasilievici G; National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM, Splaiul Independentei 202, 060021 Bucharest, Romania.; Ficai A; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania. |
| Source: | Molecules (Basel, Switzerland) [Molecules] 2022 Aug 30; Vol. 27 (17). Date of Electronic Publication: 2022 Aug 30. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, c1995- |
| MeSH Terms: | Silicon Dioxide*/chemistry ; Vancomycin*; Drug Carriers/chemistry ; Adsorption ; Polysorbates ; Porosity ; Solubility ; Solvents ; Spectroscopy, Fourier Transform Infrared ; Starch |
| Abstract: | Since its first use as a drug delivery system, mesoporous silica has proven to be a surprisingly efficient vehicle due to its porous structure. Unfortunately, most synthesis methods are based on using large amounts of surfactants, which are then removed by solvent extraction or heat treatment, leading to an undesired environmental impact because of the generated by-products. Hence, in the present study, we followed the synthesis of a silica material with a wormhole-like pore arrangement, using two FDA-approved substances as templates, namely Tween-20 and starch. As far as we know, it is the first study using the Tween-20/starch combo as a template for mesoporous silica synthesis. Furthermore, we investigated whether the obtained material using this novel synthesis had any potential in using it as a DDS. The material was further analyzed by XRD, TEM, FT-IR, N2 adsorption/desorption, and DLS to investigate its physicochemical features. Vancomycin was selected as the active molecule based on the extensive research engaged towards improving its bioavailability for oral delivery. The drug was loaded onto the material by using three different approaches, assuming its full retention in the final system. Thermal analysis confirmed the successful loading of vancomycin by all means, and pore volume significantly decreased upon loading, especially in the case of the vacuum-assisted method. All methods showed a slower release rate compared to the same amount of the pure drug. Loadings by physical mixing and solvent evaporation released the whole amount of the drug in 140 min, and the material loaded by the vacuum-assisted method released only 68.2% over the same period of time, leading us to conclude that vancomycin was adsorbed deeper inside the pores. The kinetic release of the three systems followed the Higuchi model for the samples loaded by physical mixing and vacuum-assisted procedures, while the solvent evaporation loading method was in compliance with the first-order model. |
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| Contributed Indexing: | Keywords: drug delivery; mesoporous silica; physical mixing; solvent evaporation; vacuum-assisted loading; wormhole porosity |
| Substance Nomenclature: | 0 (Drug Carriers); 0 (Polysorbates); 0 (Solvents); 6Q205EH1VU (Vancomycin); 7631-86-9 (Silicon Dioxide); 9005-25-8 (Starch) |
| Entry Date(s): | Date Created: 20220909 Date Completed: 20220912 Latest Revision: 20250728 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9458150 |
| DOI: | 10.3390/molecules27175589 |
| PMID: | 36080354 |
| Database: | MEDLINE |
Journal Article