Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells.
| Title: | Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells. |
|---|---|
| Authors: | Tran T; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Lavillegrand JR; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Lereverend C; Université de Reims Champagne Ardenne, IRMAIC EA 7509, 51097, Reims, France.; Esposito B; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Cartier L; Université de Reims Champagne Ardenne, IRMAIC EA 7509, 51097, Reims, France.; Département de Recherche, Institut Godinot, 51100, Reims, France.; Montabord M; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Tran-Rajau J; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Diedisheim M; Service de diabétologie, Hôpital Cochin APHP. GlandOmics, Cheverny, Paris, France.; Gruel N; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Centre, Institut Curie, 75005, Paris, France.; Department of Translational Research, Institut Curie Research Centre, Institut Curie, 75005, Paris, France.; Ouguerram K; Université de Nantes, INRAE, UMR 1280 PhAN, Nantes, France.; Paolini L; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Lenoir O; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Pinteaux E; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Brabencova E; Département de Recherche, Institut Godinot, 51100, Reims, France.; Tanchot C; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Urquia P; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Lehmann-Che J; Université Paris Cité, INSERM, U976 HIPI, F-75010, Paris, France.; Molecular Oncology Unit, Saint Louis Hospital, APHP, F-75010, Paris, France.; Le Naour R; Université de Reims Champagne Ardenne, IRMAIC EA 7509, 51097, Reims, France.; Merrouche Y; Université de Reims Champagne Ardenne, IRMAIC EA 7509, 51097, Reims, France.; Département de Recherche, Institut Godinot, 51100, Reims, France.; Stockmann C; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; University of Zurich, Institute of Anatomy, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland.; Mallat Z; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.; Tedgui A; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Ait-Oufella H; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Tartour E; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; AP-HP Hôpital Européen Georges Pompidou. Service d'immunologie, Paris, France.; Potteaux S; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France. stephane.potteaux@inserm.fr.; Université Paris Cité, INSERM, U976 HIPI, F-75010, Paris, France. stephane.potteaux@inserm.fr. |
| Source: | Nature communications [Nat Commun] 2022 Sep 14; Vol. 13 (1), pp. 5399. Date of Electronic Publication: 2022 Sep 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : Nature Pub. Group |
| MeSH Terms: | Dyslipidemias*/pathology ; Monocytes*/pathology; Carcinogenesis/pathology ; Cell Transformation, Neoplastic/pathology ; Inflammation/pathology ; Myeloid Cells/pathology ; Animals ; Mice ; Mice, Inbred C57BL ; Tumor Microenvironment |
| Abstract: | Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic environment and its associated low-grade inflammation in tumor progression remains underexplored. Here we show that feeding C57BL/6J mice with a non-obesogenic high fat high cholesterol diet (HFHCD) for two weeks to induce mild dyslipidemia, increases the pool of circulating Ly6Chi monocytes available for initial melanoma development, in an IL-1β-dependent manner. Descendants of circulating myeloid cells, which accumulate in the tumor microenvironment of mice under HFHCD, heighten pro-angiogenic and immunosuppressive activities locally. Limiting myeloid cell accumulation or targeting VEGF-A production by myeloid cells decrease HFHCD-induced tumor growth acceleration. Reverting the HFHCD to a chow diet at the time of tumor implantation protects against tumor growth. Together, these data shed light on cross-disease communication between cardiovascular pathologies and cancer.; (© 2022. The Author(s).) |
| References: | Mol Immunol. 2020 Jan;117:139-146. (PMID: 31778913); J Immunol. 2018 Jan 15;200(2):422-431. (PMID: 29311384); Cancer Cell. 2004 Dec;6(6):553-63. (PMID: 15607960); Eur Heart J. 2019 Dec 21;40(48):3901-3909. (PMID: 31504409); Annu Rev Pathol. 2016 May 23;11:421-49. (PMID: 27193454); Cell Rep. 2016 Apr 12;15(2):336-48. (PMID: 27050512); Nat Rev Immunol. 2015 Feb;15(2):104-16. (PMID: 25614320); Trends Immunol. 2016 Mar;37(3):208-220. (PMID: 26858199); Nat Med. 2020 Sep;26(9):1452-1458. (PMID: 32661390); J Exp Med. 2015 Feb 9;212(2):139-48. (PMID: 25601652); Lancet. 2017 Oct 21;390(10105):1833-1842. (PMID: 28855077); Blood. 2010 Nov 11;116(19):3955-63. (PMID: 20682855); Front Immunol. 2018 Nov 13;9:2629. (PMID: 30483271); J Lipid Res. 1964 Oct;5:600-8. (PMID: 14221106); Oncotarget. 2016 Jun 21;7(25):38959-38972. (PMID: 27029038); J Clin Invest. 2017 Aug 1;127(8):3039-3051. (PMID: 28691930); Int J Mol Sci. 2018 Jul 24;19(8):. (PMID: 30042333); Innovation (Camb). 2021 Jul 01;2(3):100141. (PMID: 34557778); Arch Intern Med. 2008 Aug 11;168(15):1617-24. (PMID: 18695075); Circulation. 2008 Apr 1;117(13):1649-57. (PMID: 18347211); Cancer Res. 2021 Mar 1;81(5):1201-1208. (PMID: 33203697); Circulation. 2016 Mar 15;133(11):1104-14. (PMID: 26976915); Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):378-88. (PMID: 25524776); Horm Metab Res. 2015 Oct;47(11):839-45. (PMID: 26340705); Biomed Pharmacother. 2002 Oct;56(8):365-79. (PMID: 12442909); J Clin Invest. 2007 Jan;117(1):195-205. (PMID: 17200719); Oncogene. 2013 Feb 21;32(8):961-7. (PMID: 22469977); Nat Med. 2018 Feb;24(2):144-153. (PMID: 29309059); J Immunol. 2007 Feb 1;178(3):1505-11. (PMID: 17237399); PLoS One. 2017 Jun 15;12(6):e0179065. (PMID: 28617818); Nat Commun. 2016 Aug 19;7:12528. (PMID: 27538380); Eur J Immunol. 2016 Apr;46(4):912-8. (PMID: 26692072); Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):. (PMID: 33649199); J Vasc Interv Radiol. 2018 Apr;29(4):441-453. (PMID: 29478797); Br J Cancer. 2020 Jan;122(1):4-22. (PMID: 31819192); Science. 2013 Nov 29;342(6162):1094-8. (PMID: 24288332); Nat Rev Cancer. 2013 Oct;13(10):739-52. (PMID: 24060865); FASEB J. 2015 Mar;29(3):748-58. (PMID: 25411437); Nature. 2012 Jul 19;487(7407):325-9. (PMID: 22763456); Int J Cancer. 2015 May 15;136(10):2352-60. (PMID: 25353097); J Leukoc Biol. 2012 Jan;91(1):167-81. (PMID: 21954284); Nat Commun. 2018 Apr 3;9(1):1310. (PMID: 29615667); Nature. 2011 Jun 08;475(7355):222-5. (PMID: 21654748); Nutr Cancer. 2007;59(2):207-16. (PMID: 18001216); Am J Cancer Res. 2019 Feb 01;9(2):219-227. (PMID: 30906624); Cold Spring Harb Perspect Biol. 2011 Mar 01;3(3):. (PMID: 21123394); J Am Coll Cardiol. 2017 Oct 31;70(18):2278-2289. (PMID: 29073957); Cell. 2018 Jan 11;172(1-2):147-161.e12. (PMID: 29328910); Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2645-50. (PMID: 12598651); Hum Vaccin Immunother. 2022 May 31;18(3):1926759. (PMID: 34190675); Am J Pathol. 2010 Dec;177(6):3180-91. (PMID: 21088217); Cells. 2021 Dec 22;11(1):. (PMID: 35011579) |
| Grant Information: | CH/10/001/27642 United Kingdom BHF_ British Heart Foundation |
| Entry Date(s): | Date Created: 20220914 Date Completed: 20220916 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9475043 |
| DOI: | 10.1038/s41467-022-33034-0 |
| PMID: | 36104342 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't