SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion.
| Title: | SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion. |
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| Authors: | De Luca G; Division of Clinical and Experimental Cardiology, AOU Sassari, Sassari, Italy Division of Cardiology, Ospedale Nuovo Galeazzi, Milan, Italy.; Algowhary M; Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut, Egypt.; Uguz B; Division of Cardiology, Bursa City Hospital, Bursa, Turkey.; Oliveira DC; Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife, Brasil.; Ganyukov V; Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.; Zimbakov Z; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, Skopje, North Macedonia.; Cercek M; Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, Slovenia.; Okkels Jensen L; Division of Cardiology, Odense Universitets Hospital, Odense, Denmark.; Loh PH; Department of Cardiology, National University Hospital, Singapore.; Calmac L; Clinic Emergency Hospital of Bucharest, Romania.; Roura I Ferrer G; Interventional Cardiology Unit, Heart Disease Institute. Hospital Universitari de Bellvitge, Spain.; Quadros A; Instituto de Cardiologia Do Rio Grande Do Sul, Porto Alegre.; Milewski M; Division of Cardiology, Medical University of Silezia, Katowice, Poland.; Scotto Di Uccio F; Division of Cardiology, Ospedale Del Mare, Napoli, Italy.; von Birgelen C; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Enschede, The Netherlands.; Technical Medical Centre, Health Technologies and Services Research, University of Twente, Enschede, Netherlands.; Versaci F; Division of Cardiology, Ospedale Santa Maria Goretti Latina, Italy.; Ten Berg J; Division of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.; Casella G; Division of Cardiology, Ospedale Maggiore Bologna, Italy.; Wong Sung Lung A; Department of Cardiology, National Heart Center, Singapore.; Kala P; University Hospital Brno, Medical Faculty of Masaryk University Brno, Czech Republic.; Díez Gil JL; H. Universitario y Politécnico La Fe, Valencia, Spain.; Carrillo X; Hospital Germans Triasi Pujol, Badalona, Spain.; Dirksen M; Division of Cardiology, Northwest Clinics Alkmaar, The Netherlands.; Becerra-Munoz VM; Hospital Clínico Universitario Virgen de La Victoria, Málaga, Spain.; Kang-Yin Lee M; Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong.; Juzar DA; Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center 'Harapan Kita', Jakarta.; de Moura Joaquim R; Instituto de Cardiologia de Santa Catarina Praia Comprida, São José, Brasil.; De Simone C; Division of Cardiology, Clinica Villa Dei Fiori, Acerra, Italy.; Milicic D; Department of Cardiology, University Hospital Centre, University of Zagreb, Zagreb, Croatia.; Davlouros P; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, Greece.; Bakraceski N; Center for Cardiovascular Diseases, Ohrid, North Macedonia.; Zilio F; Division of Cardiology, Ospedale Santa Chiara di Trento, Italy.; Donazzan L; Division of Cardiology, Ospedale 'S. Maurizio', Bolzano, Italy.; Kraaijeveld A; Division of Cardiology, UMC Utrecht, The Netherlands.; Galasso G; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy.; Arpad L; Maastricht University Medical Center, Utrecht, Netherlands.; Marinucci L; Division of Cardiology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Pesaro, Italy.; Guiducci V; Division of Cardiology, AUSL-IRCCS Reggio Emilia, Italy.; Menichelli M; Division of Cardiology, Ospedale 'F. Spaziani', Frosinone, Italy.; Scoccia A; Division of Cardiology, Ospedale 'Sant'Anna', Ferrara, Italy.; Yamac AH; Department of Cardiology, Hospital Bezmialem Vakıf University İstanbul, Istanbul, Turkey.; Ugur Mert K; Division of Cardiology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.; Flores Rios X; Complexo Hospetaliero Universitario La Coruna, La Coruna, Spain.; Kovarnik T; University Hospital Prague, Czech Republic.; Kidawa M; Central Hospital of Medical University of Lodz, Poland.; Moreu J; Division of Cardiology, Complejo Hospitalario de Toledo, Toledo, Spain.; Flavien V; Division of Cardiology, Center Hospitalier Universitaire de Lille, Lille, France.; Fabris E; Azienda Ospedaliero - Universitaria Ospedali Riuniti Trieste, Italy.; Lozano Martínez-Luengas I; Division of Cardiology, Hospital Cabueñes, Gijon, Spain.; Boccalatte M; Division of Cardiology, Ospedale Santa Maria Delle Grazie, Pozzuoli, Italy.; Bosa Ojeda F; Division of Cardiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife.; Arellano-Serrano C; Division of Cardiology, Hospital Puerta de Hierro Majadahonda, Spain.; Caiazzo G; Division of Cardiology, Ospedale 'G Moscati', Aversa, Italy.; Cirrincione G; Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.; Kao HL; Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, Tapei, Taiwan.; Sanchis Forés J; Division of Cardiology, Hospital Clinico Universitario de Valencia, Spain.; Vignali L; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy.; Pereira H; Hospital Garcia de Orta, Cardiology Department, Pragal, Almada, Portugal.; Manzo-Silbermann S; Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, France.; Ordoñez S; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.; Arat Özkan A; Cardiology Institute, Instanbul University, Instanbul, Turkey.; Scheller B; Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, Germany.; Lehtola H; Division of Cardiology, Oulu University Hospital, Finland.; Teles R; Division of Cardiology, Hospital de Santa Cruz, CHLO - Nova Medical School, CEDOC, Lisbon, Portugal.; Mantis C; Division of Cardiology, Konstantopoulion Hospital, Athens, Greece.; Antti Y; Division of Cardiology, Heart Centre Turku, Finland.; Brum Silveira JA; Division of Cardiology, Hospital de Santo António, Porto, Portugal.; Bessonov I; Tyumen Cardiology Research Center, Russia.; Zoni R; Department of Teaching and Research, Instituto de Cardiología de Corrientes 'Juana F. Cabral', Argentina.; Savonitto S; Division of Cardiology, Ospedale 'A. Manzoni' Lecco, Italy.; Kochiadakis G; Iraklion University Hospital, Crete, Greece.; Alexopoulos D; Division of Cardiology, Attikon University Hospital, Athens, Greece.; Uribe CE; Carlos E Uribe, Division of Cardiology, Universidad UPB, Universidad CES, Medellin, Colombia.; Kanakakis J; Division of Cardiology, Alexandra Hospital, Athens, Greece.; Faurie B; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, France.; Gabrielli G; Interventional Cardiology Unit, Azienda Ospedaliero Universitaria 'Ospedali Riuniti', Ancona, Italy.; Gutierrez Barrios A; Division of Cardiology, Hospital Puerta Del Mar, Cadiz, Spain.; Bachini JP; Instituto de Cardiologia Integral, Montevideo, Uruguay.; Rocha A; Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo, Uruguay.; Tam FC; Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong.; Rodriguez A; Division of Cardiology, Otamendi Hospital, Buenos Aires, Argentina.; Lukito AA; Cardiovascular Department Pelita Harapan University/Heart Center Siloam Lippo Village Hospital, Tangerang, Banten, Indonesia.; Bellemain-Appaix A; Center Hospitalier D'Antibes Juan Les Pins, Antibes, France.; Pessah G; Division of Cardiology, Hospiatl Cordoba, Cordoba, Argentina.; Cortese G; Department of Statistical Sciences, University of Padova, Italy.; Parodi G; Division of Cardiology, Ospedale di Lavagna, Italy.; Burgadha MA; Division of Cardiology, Blida University Hospital, Blida, Algeria.; Kedhi E; Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, Belgium.; Lamelas P; Instituto Cardiovascular de Buenos Aires, Argentina.; Suryapranata H; Division of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.; Nardin M; Department of Internal Medicine, Ospedale Riuniti, Brescia, Italy.; Verdoia M; Division of Cardiology, Ospedale Degli Infermi, ASL Biella, Italy. |
| Source: | Angiology [Angiology] 2023 Nov-Dec; Vol. 74 (10), pp. 987-996. Date of Electronic Publication: 2022 Oct 12. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Sage Publications Country of Publication: United States NLM ID: 0203706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-1574 (Electronic) Linking ISSN: 00033197 NLM ISO Abbreviation: Angiology Subsets: MEDLINE; PubMed not MEDLINE |
| Imprint Name(s): | Publication: Thousand Oaks, CA : Sage Publications; Original Publication: New York [etc.] Angiology Research Foundation. |
| Abstract: | SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P = .002), less often active smokers (P = .002), and hypercholesterolemic (P = .006), they presented more often later than 12 h (P = .037), more often to the hub and were more often in cardiogenic shock (P = .02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P < .0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P = .029) and more thrombectomy (P = .046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P < .001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P < .001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P < .001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences. |
| Competing Interests: | Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Contributed Indexing: | Keywords: STEMI; outcome; thrombosis |
| Entry Date(s): | Date Created: 20221012 Latest Revision: 20231020 |
| Update Code: | 20260130 |
| DOI: | 10.1177/00033197221129351 |
| PMID: | 36222189 |
| Database: | MEDLINE |
Journal Article