A saturated map of common genetic variants associated with human height.
| Title: | A saturated map of common genetic variants associated with human height. |
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| Authors: | Yengo L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. l.yengo@imb.uq.edu.au.; Vedantam S; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Sidorenko J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Bartell E; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Sakaue S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.; Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Eliasen AU; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark.; Jiang Y; 23andMe, Sunnyvale, CA, USA.; Raghavan S; Department of Veterans Affairs, Eastern Colorado Healthcare System, Aurora, CO, USA.; Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Miao J; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Arias JD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Mukamel RE; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Spracklen CN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.; Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Chen SH; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Ferreira T; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Highland HH; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Ji Y; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK.; Karaderi T; Center for Health Data Science, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Lüll K; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.; Malden DE; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Machado M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Moore A; Division of Biostatistics and Epidemiology, RTI International, Durham, NC, USA.; Rüeger S; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; Ahluwalia TS; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Biology, The Bioinformatics Center, University of Copenhagen, Copenhagen, Denmark.; Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Allison MA; Department of Family Medicine, University of California, San Diego, La Jolla, CA, USA.; Alvarez M; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Andersen MK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran.; Appadurai V; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; Arbeeva L; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Bhaskar S; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Bonnycastle LL; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Bradfield JP; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Quantinuum Research, Wayne, PA, USA.; Bradford Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Burgdorf KS; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; NovoNordic Center for Protein Research, Copenhagen University, Copenhagen, Denmark.; Cade BE; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Cai H; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, UK.; Catamo E; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore.; Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Chesi A; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Choi SH; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Chung RH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.; Cocca M; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Concas MP; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Couture C; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada.; Cuellar-Partida G; 23andMe, Sunnyvale, CA, USA.; Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.; Danning R; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; Degenhard F; Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany.; Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Delitala A; Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Università degli Studi di Sassari, Sassari, Italy.; Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.; Deng X; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Devineni P; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Dietl A; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.; Dimitriou M; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece.; Dimitrov L; Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.; Ekici AB; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Engmann JE; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.; Fairhurst-Hunter Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Farmaki AE; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece.; Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Fernandez-Lopez JC; Computational Genomics Department, National Institute of Genomic Medicine, Mexico City, Mexico.; Forer L; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; Francescatto M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.; Fuchsberger C; Eurac Research, Institute for Biomedicine, Affiliated Institute of the University of Lübeck, Bolzano, Italy.; Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.; Gao Y; Jackson Heart Study, Department of Medicine, University of Mississippi, Jackson, MS, USA.; Gao Z; Nanjing University of Chinese Medicine, Nanjing, China.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Goel A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Gordon SD; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Grove J; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; BiRC-Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.; Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Gustafsson S; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Hansen TF; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; NovoNordic Center for Protein Research, Copenhagen University, Copenhagen, Denmark.; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Rigshospitalet, Copenhagen, Denmark.; Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Haworth SJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Dental School, University of Bristol, Bristol, UK.; He J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Heard-Costa N; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.; Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.; Hindy G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.; Ho YA; Veterans Affairs Boston Healthcare System, Boston, MA, USA.; Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.; Holliday E; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.; Horn K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany.; Hornsby WE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Hottenga JJ; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Huang H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Huang J; School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.; Institute for Global Health and Development, Peking University, Beijing, China.; Huerta-Chagoya A; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México Ciudad Universitaria, Mexico City, Mexico.; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.; Huffman JE; Veterans Affairs Boston Healthcare System, Boston, MA, USA.; Hung YJ; Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.; Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea.; Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan.; Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan.; Isono M; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.; Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Jansen IE; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.; Johansson I; Department of Biobank Research, Umeå University, Umeå, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden.; Jonas JB; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.; Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.; Jonsson A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Jørgensen T; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Kalafati IP; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece.; Kanai M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Kårhus LL; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Kasturiratne A; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.; Katsuya T; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.; Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Kember RL; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.; Kentistou KA; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design and Evaluation (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea.; Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea.; Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.; Knol MJ; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Kurbasic A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Lauzon M; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Le P; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada.; Lea R; Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.; Lee JY; Oneomics, Soonchunhyang Mirai Medical Center, Bucheon-si, Republic of Korea.; Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.; Li SA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research, Rockville, MD, USA.; Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Department of Mathematics and Statistics, St Cloud State University, St Cloud, MN, USA.; Liang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Lin H; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Lin SY; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.; Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Liu X; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Lo KS; Montreal Heart Institute, Montreal, Quebec, Canada.; Long J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Lores-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.; Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Lyssenko V; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.; Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.; Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Mamakou V; National and Kapodistrian University of Athens, Dromokaiteio Psychiatric Hospital, Athens, Greece.; Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.; Manichaikul A; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.; Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Mattheisen M; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; Department of Psychiatry and Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Mavarani L; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.; McDaid AF; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Melendez TL; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Mercader JM; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Milaneschi Y; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC and Vrije Universiteit, Amsterdam, The Netherlands.; Miller JE; Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, USA.; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Mitchell RE; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Møllehave LT; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Morgan A; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Mucha S; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany.; Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany.; Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Nho CW; Korea Institute of Science and Technology, Gangneung Institute of Natural Products, Gangneung, Republic of Korea.; Nielsen AA; Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark.; Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Nongmaithem SS; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Nutile T; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy.; Pandit A; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Pärna K; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.; Petersen ERB; Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Aabenraa, Denmark.; Petersen LV; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; The National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark.; Pitkänen N; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Polašek O; Medical School, University of Split, Split, Croatia.; Algebra University College, Zagreb, Croatia.; Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pyarajan S; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Rakugi H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan.; Ramirez J; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.; Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan.; Raven D; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; Riveros C; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, New South Wales, Australia.; Rohde R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Ruggiero D; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Italy.; Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Ryan KA; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Sabater-Lleal M; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden.; Saxena R; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany.; Sendamarai A; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA.; Shen B; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Shi J; 23andMe, Sunnyvale, CA, USA.; Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.; Sidore C; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.; Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Slieker RC; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Epidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Smit RAJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Smith AV; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Icelandic Heart Association, Kópavogur, Iceland.; Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK.; Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Sanger Institute, Hinxton, UK.; Steinthorsdottir V; deCODE Genetics/Amgen, Reykjavik, Iceland.; Sun L; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; Takeuchi F; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.; Tallapragada DSP; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Tayo BO; Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.; Tcheandjieu C; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Tesolin P; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Theusch E; Cardiology Division, Department of Pediatrics, University of California, San Francisco, Oakland, CA, USA.; Thompson DJ; Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Thorleifsson G; deCODE Genetics/Amgen, Reykjavik, Iceland.; Timmers PRHJ; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Vaccargiu S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.; van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; van Klinken JB; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Verma SS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Veturi Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Wang CA; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, New South Wales, Australia.; Wang C; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Warren HR; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Bin Wei W; Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Wickremasinghe AR; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.; Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Dermatology, Medical University of Vienna, Vienna, Austria.; Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Winsvold BS; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.; Wong A; MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.; Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Wuttke M; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Department of Medicine IV - Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Xia R; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Yamamoto K; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.; Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Young H; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt.; Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Zeng L; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.; Zhang W; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Zhang X; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Zhao W; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Zhou W; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Zoledziewska M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.; Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Adams HHH; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Aguilar-Salinas CA; Unidad de Investigacion de Enfermedades Metabolicas and Direction of Nutrition, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico.; Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.; Arnett DK; Department of Epidemiology and Dean's Office, College of Public Health, University of Kentucky, Lexington, KY, USA.; Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK.; Åsvold BO; KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Attia J; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.; Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Bandinelli S; Geriatric Unit, Azienda Toscana Centro, Florence, Italy.; Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Bergler T; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Bharadwaj D; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University (JNU), New Delhi, India.; Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.; Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Boerwinkle E; Human Genetics Center and Department of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX, USA.; Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany.; Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Boomsma DI; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Børglum AD; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.; Borja JB; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines.; Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Bowden DW; Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Brumpton B; KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Buring JE; Harvard Medical School, Boston, MA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Caulfield MJ; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Chambers JC; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; Chandak GR; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Adjunct Faculty, JSS University Academy of Higher Education and Research (JSSAHER), JSS (Deemed to be) University, Mysuru, India.; Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.; Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Christophersen IE; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Ciullo M; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Italy.; Cole JW; Department of Neurology, Division of Vascular Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Medical Center, Department of Neurology, Baltimore, MD, USA.; Collins FS; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Cooper RS; Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.; Cruz M; Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.; Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.; Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Damrauer SM; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Dantoft TM; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; de Borst GJ; Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; de Groot LCPGM; Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands.; De Jager PL; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.; de Kleijn DPV; Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Janaka de Silva H; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.; Dedoussis GV; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece.; den Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.; Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Easton DF; Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Elders PJM; Department of General Practice, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.; Eliassen AH; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Elmståhl S; Department of Clinical Sciences in Malmö, Division of Geriatric Medicine, Lund University, Malmö, Sweden.; Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany.; Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Fatkin D; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.; Faculty of Medicine, UNSW Sydney, Kensington, New South Wales, Australia.; Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; Ferrucci L; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.; Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany.; Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; Freedman BI; Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Gasparini P; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Girotto G; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Goddard ME; Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Victoria, Australia.; Agriculture Victoria Research, Department of Jobs, Precincts and Regions, Bundoora, Victoria, Australia.; Golightly YM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Gonzalez-Villalpando C; Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud Publica and Centro de Estudios en Diabetes, Cuernavaca, Mexico.; Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Departments of Pediatrics and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Griffiths L; Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.; Gudnason V; Icelandic Heart Association, Kópavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Haiman C; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Hartman CA; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.; Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Heckbert SR; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.; Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.; Hengstenberg C; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.; Hewitt AW; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia.; Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, Perth, Western Australia, Australia.; Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan.; Hoyng CB; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.; Huang PL; Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.; Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Heath and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai, China.; Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.; Hveem K; KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.; Hyppönen E; Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Iacono WG; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.; Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Jackson RD; Division of Endocrinology, Diabetes and Metabolism, School of Medicine, Ohio State University, Columbus, OH, USA.; Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK.; Jin ZB; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.; Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.; Joshi PK; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.; Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Kang KD; Department of Ophthalmology, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, Republic of Korea.; Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Kato N; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.; Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, UK.; Kessler T; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.; Khera AV; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Kiemeney LALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, The Netherlands.; Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea.; Kim EK; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Saevit Eye Hospital, Goyang, Republic of Korea.; Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.; Kirchhof P; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.; Atrial Fibrillation NETwork, Münster, Germany.; Kivimaki M; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.; Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.; Kolovou GD; Department of Preventive Cardiology, Lipoprotein Apheresis Unit and Lipid Disorders Clinic, Metropolitan Hospital, Athens, Greece.; Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Kovacs P; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Kraaijeveld A; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Krauss RM; Cardiology Division, Department of Pediatrics, University of California, San Francisco, Oakland, CA, USA.; Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK.; Kutalik Z; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.; Lange LA; Department of Medicine, University of Colorado at Denver, Aurora, CO, USA.; Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.; Lee H; Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea.; Lee NR; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; Li L; Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.; Lieb W; Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.; Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China.; Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Linneberg A; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany.; London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.; Lubitz SA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Lye SJ; Alliance for Human Development, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Mackey DA; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.; Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, Perth, Western Australia, Australia.; Mägi R; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.; Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Marcus GM; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA.; Vidal PM; Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.; University of Lausanne, Lausanne, Switzerland.; Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB Academy, SYNLAB Holding Deutschland, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; McGarrah RW; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK.; Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Metspalu A; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.; Mitchell BD; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.; Mitchell P; Centre for Vision Research and Department of Ophthalmology, Westmead Millennium Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.; Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Mucci LA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Munroe PB; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.; Nazarian S; Electrophysiology Section, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Nelson AE; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Newton-Cheh C; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Nielsen CS; Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.; Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.; Nöthen MM; Institute of Human Genetics, School of Medicine and University Hospital Bonn, Bonn, Germany.; Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden.; Oldehinkel AJ; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Orozco L; Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, CDMX, Mexico City, Mexico.; Pahkala K; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland.; Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Palmer CNA; Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada.; Pattaro C; Eurac Research, Institute for Biomedicine, Affiliated Institute of the University of Lübeck, Bolzano, Italy.; Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Pennell CE; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, New South Wales, Australia.; Penninx BWJH; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC and Vrije Universiteit, Amsterdam, The Netherlands.; Perusse L; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada.; Centre Nutrition, Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods, Université Laval, Québec City, Quebec, Canada.; Peters A; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; IBE-Chair of Epidemiology, LMU Munich, Neuherberg, Germany.; Peyser PA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Power C; Population, Policy and Practice, UCL Great Ormond Street Hospital Institute of Child Health, London, UK.; Pramstaller PP; Eurac Research, Institute for Biomedicine, Affiliated Institute of the University of Lübeck, Bolzano, Italy.; Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.; Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.; Rader DJ; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Ralhan S; Hero DMC Heart Institute, Dyanand Medical College, Ludhiana, India.; Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital Attikon, Athens, Greece.; Rao DC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.; Redline S; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Reilly DF; Genetics, Merck Sharp & Dohme, Kenilworth, NJ, USA.; Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.; Ridker PM; Harvard Medical School, Boston, MA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Ripatti S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Ritchie MD; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Rudan I; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; Rutters F; Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.; Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Saleheen D; Center for Non-Communicable Diseases, Karachi, Pakistan.; Department of Cardiology and Department of Medicine, Columbia University, New York, NY, USA.; Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Sanghera DK; Department of Pediatrics, Section of Genetics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.; Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.; Schmidt H; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria.; Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.; Schunkert H; Deutsches Herzzentrum München, Cardiology, Deutsches Zentrum für Herz- und Kreislaufforschung (DZHK) - Munich Heart Alliance, and Technische Universität München, München, Germany.; Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Scott RJ; School of Biomedical Science and Pharmacy, University of Newcastle, New Lambton Heights, New South Wales, Australia.; Sever P; National Heart and Lung Institute, Imperial College London, London, UK.; Shiroma EJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Shoemaker MB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Simonsick EM; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi, Jackson, MS, USA.; Singh JR; Central University of Punjab, Bathinda, India.; Singleton AB; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Sinner MF; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.; Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Stampfer MJ; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Strachan DP; Population Health Research Institute, St George's, University of London, London, UK.; 't Hart LM; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Epidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Molecular Epidemiology Section, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.; Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Tang H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.; Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.; Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Tönjes A; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Tremblay A; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada.; Centre Nutrition, Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods, Université Laval, Québec City, Quebec, Canada.; Tuomi T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.; Helsinki University Central Hospital, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Tusié-Luna MT; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Uitterlinden AG; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.; van der Harst P; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Van der Velde N; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department Geriatric Medicine, Amsterdam Public Health, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; van Schoor NM; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.; Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Völker U; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.; University of Lausanne, Lausanne, Switzerland.; Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Wacher-Rodarte NH; Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.; Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.; Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.; Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Watanabe RM; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Keck School of Medicine of USC, Los Angeles, CA, USA.; Watkins H; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Werge TM; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Lundbeck Foundation Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.; Widen E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.; Willemsen G; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Willett WC; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Wilson JF; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.; Wright AF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan.; Xu H; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Yajnik CS; Diabetes Unit, KEM Hospital and Research Centre, Pune, India.; Yokota M; Kurume University School of Medicine, Kurume, Japan.; Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Sanger Institute, Hinxton, UK.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany.; Zemel BS; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Zmuda JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.; Zwart JA; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Chasman DI; Harvard Medical School, Boston, MA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.; Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; Genentech, South San Francisco, CA, USA.; Ng MCY; Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; O'Donnell CJ; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Veterans Affairs Boston Healthcare System, Boston, MA, USA.; Rivadeneira F; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Thorsteinsdottir U; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA.; Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Deloukas P; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.; Justice AE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Population Health Sciences, Geisinger, Danville, PA, USA.; Lindgren CM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Young KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Loh PR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Esko T; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.; Assimes TL; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Auton A; 23andMe, Sunnyvale, CA, USA.; Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Lettre G; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.; Frayling TM; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK.; Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. yokada@sg.med.osaka-u.ac.jp.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. yokada@sg.med.osaka-u.ac.jp.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka, Japan. yokada@sg.med.osaka-u.ac.jp.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan. yokada@sg.med.osaka-u.ac.jp.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. yokada@sg.med.osaka-u.ac.jp.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. yokada@sg.med.osaka-u.ac.jp.; Wood AR; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK. A.R.Wood@exeter.ac.uk.; Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. peter.visscher@uq.edu.au.; Hirschhorn JN; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA. Joel.Hirschhorn@childrens.harvard.edu.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Joel.Hirschhorn@childrens.harvard.edu.; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA. Joel.Hirschhorn@childrens.harvard.edu. |
| Corporate Authors: | 23andMe Research Team; VA Million Veteran Program; DiscovEHR (DiscovEHR and MyCode Community Health Initiative); eMERGE (Electronic Medical Records and Genomics Network); Lifelines Cohort Study; PRACTICAL Consortium; Understanding Society Scientific Group |
| Source: | Nature [Nature] 2022 Oct; Vol. 610 (7933), pp. 704-712. Date of Electronic Publication: 2022 Oct 12. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Imprint Name(s): | Publication: Basingstoke : Nature Publishing Group; Original Publication: London, Macmillan Journals ltd. |
| MeSH Terms: | Body Height*/genetics ; Polymorphism, Single Nucleotide*/genetics ; Chromosome Mapping*; Gene Frequency/genetics ; Genome, Human/genetics ; Haplotypes/genetics ; Linkage Disequilibrium/genetics ; Europe/ethnology ; Humans ; Genome-Wide Association Study ; Sample Size ; Phenotype |
| Abstract: | Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.; (© 2022. The Author(s).) |
| Comments: | Comment in: Nature. 2022 Oct;610(7933):631-632. doi: 10.1038/d41586-022-03029-4.. (PMID: 36224358) |
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| Grant Information: | R01 DK093757 United States DK NIDDK NIH HHS; MC_UU_00007/10 United Kingdom MRC_ Medical Research Council; U10 HL054472 United States HL NHLBI NIH HHS; U01 HL054472 United States HL NHLBI NIH HHS; S10 OD017985 United States OD NIH HHS; P30 AG072975 United States AG NIA NIH HHS; R01 DA005147 United States DA NIDA NIH HHS; RC4 AG039029 United States AG NIA NIH HHS; DA037904 United States DA NIDA NIH HHS; MC_U137686851 United Kingdom MRC_ Medical Research Council; R01 DA036216 United States DA NIDA NIH HHS; N02-HL-64278 United States HL NHLBI NIH HHS; RC2 MH089951 United States MH NIMH NIH HHS; HL113338 United States HL NHLBI NIH HHS; S10RR025141 United States RR NCRR NIH HHS; G1001799 United Kingdom MRC_ Medical Research Council; U01 HL054471 United States HL NHLBI NIH HHS; U54MD007593 United States MD NIMHD NIH HHS; U01HL080295 United States HL NHLBI NIH HHS; 29017 United Kingdom CRUK_ Cancer Research UK; G0601463 United Kingdom MRC_ Medical Research Council; U01 AG046152 United States AG NIA NIH HHS; 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N01 HC095161 United States HL NHLBI NIH HHS; N01-HC65233 United States HL NHLBI NIH HHS; R01DK072193 United States DK NIDDK NIH HHS; U01 HG004438 United States HG NHGRI NIH HHS; R01 HG003054 United States HG NHGRI NIH HHS; R01-NS114045 United States NS NINDS NIH HHS; HHSN268201800012I United States HB NHLBI NIH HHS; R01 AA007535 United States AA NIAAA NIH HHS; R01-CA082664 United States CA NCI NIH HHS; P30 ES010126 United States ES NIEHS NIH HHS; HHSN268201800012C United States HL NHLBI NIH HHS; R01HL157635 United States HL NHLBI NIH HHS; MR/R024227/1 United Kingdom MRC_ Medical Research Council; P60 AR049465 United States AR NIAMS NIH HHS; 75N92020D00005 United States HL NHLBI NIH HHS; R01 HL067974 United States HL NHLBI NIH HHS; R01 HL104135 United States HL NHLBI NIH HHS; UM1 CA164973 United States CA NCI NIH HHS; N01-HC-95159 United States HL NHLBI NIH HHS; N01 HC095168 United States HL NHLBI NIH HHS; U01 AG023744 United States AG NIA NIH HHS; R01 HD58886 United States HD NICHD NIH HHS; UL1TR001881 United States TR NCATS NIH HHS; R01 MH081802 United States MH NIMH NIH HHS; RF1 AG015819 United States AG NIA NIH HHS; R01 CA80205 United States CA NCI NIH HHS; U01AG46152 United States AG NIA NIH HHS; U01 HG004446 United States HG NHGRI NIH HHS; R01HL086718 United States HL NHLBI NIH HHS; DA042755 United States DA NIDA NIH HHS; I01 BX004821 United States BX BLRD VA; DK056350 United States DK NIDDK NIH HHS; R01 NR013520 United States NR NINR NIH HHS; U19AG063893 United States AG NIA NIH HHS; R01 HL046380 United States HL NHLBI NIH HHS; R01DK124097 United States DK NIDDK NIH HHS; R01-NS105150 United States NS NINDS NIH HHS; R01 AA014041 United States AA NIAAA NIH HHS; U01AG023755 United States AG NIA NIH HHS; R01 HL120393 United States HL NHLBI NIH HHS; 1R01HL139731 United States HL NHLBI NIH HHS; K24 HL105780 United States HL NHLBI NIH HHS; U10 HL054509 United States HL NHLBI NIH HHS; N01-HC-95166 United States HL NHLBI NIH HHS; Z01 HG000024 United States ImNIH Intramural NIH HHS; 75N92021D00005 United States WH WHI NIH HHS; U10 CA037429 United States CA NCI NIH HHS; CA141298 United States CA NCI NIH HHS; N01-HC65237 United States HL NHLBI NIH HHS; U01AG023746 United States AG NIA NIH HHS; R01 HL111249 United States HL NHLBI NIH HHS; KL2-RR024990 United States RR NCRR NIH HHS; R35-HL135818 United States HL NHLBI NIH HHS; R01 AA009367 United States AA NIAAA NIH HHS; U01 DP006266 United States DP NCCDPHP CDC HHS; U01 AG009740 United States AG NIA NIH HHS; 212946/Z/18/Z United Kingdom WT_ Wellcome Trust; U01 HL054527 United States HL NHLBI NIH HHS; HHSN268201800004I United States HL NHLBI NIH HHS; P01 CA087969 United States CA NCI NIH HHS; U01 HL080295 United States HL NHLBI NIH HHS; N01 HG065403 United States HG NHGRI NIH HHS; UL1 RR025005 United States RR NCRR NIH HHS; R01-HL053353 United States HL NHLBI NIH HHS; U01-HL054512 United States HL NHLBI NIH HHS; RC2 MH089995 United States MH NIMH NIH HHS; N02 HL064278 United States HL NHLBI NIH HHS; P60 AR030701 United States AR NIAMS NIH HHS; P30 CA015704 United States CA NCI NIH HHS; N01 HC085082 United States HL NHLBI NIH HHS; ES010126 United States ES NIEHS NIH HHS; R01 HD030880 United States HD NICHD NIH HHS; HHSN268201100004I United States HL NHLBI NIH HHS; N01 HC065233 United States HL NHLBI NIH HHS; P30AG10161 United States AG NIA NIH HHS; U01 DK105556 United States DK NIDDK NIH HHS; P50GM115305 United States GM NIGMS NIH HHS; HHSN268201500001C United States HL NHLBI NIH HHS; R01 CA067262 United States CA NCI NIH HHS; R01 HL091357 United States HL NHLBI NIH HHS; UL1 TR001079 United States TR NCATS NIH HHS; R01HL120393 United States HL NHLBI NIH HHS; 5-P60-AR30701 United States AR NIAMS NIH HHS; N01 HC095169 United States HL NHLBI NIH HHS; UL1 TR001878 United States TR NCATS NIH HHS; HHSN268201800014I United States HB NHLBI NIH HHS; N01-HD-1-3330 United States HD NICHD NIH HHS; R01 HL092577 United States HL NHLBI NIH HHS; MC_QA137853 United Kingdom MRC_ Medical Research Council; DP2 ES030554 United States ES NIEHS NIH HHS; R-35-HL135824 United States HL NHLBI NIH HHS; U19HL065962 United States HL NHLBI NIH HHS; R01 HL043851 United States HL NHLBI NIH HHS; R01DK104371 United States DK NIDDK NIH HHS; U01 HL130114 United States HL NHLBI NIH HHS; R01 HL087660 United States HL NHLBI NIH HHS; R01HL108427 United States HL NHLBI NIH HHS; AG000513 United States AG NIA NIH HHS; R01-HL067974 United States HL NHLBI NIH HHS; U01 HG007416 United States HG NHGRI NIH HHS; R01CA148677 United States CA NCI NIH HHS; N01 HC065236 United States HL NHLBI NIH HHS; R01D0042157-01A1 United States NH NIH HHS; U01 HG008657 United States HG NHGRI NIH HHS; N01-AG-1-2100 United States AG NIA NIH HHS; 29186 United Kingdom CRUK_ Cancer Research UK; UM1 CA176726 United States CA NCI NIH HHS; U01 HG 004446 United States HG NHGRI NIH HHS; N01-HD-1-3332 United States HD NICHD NIH HHS; R01 MD009164 United States MD NIMHD NIH HHS; P01 CA055075 United States CA NCI NIH HHS; N01 HC065235 United States HL NHLBI NIH HHS; R01 HD30880 United States HD NICHD NIH HHS; HHSN268200800007C United States HL NHLBI NIH HHS; U01HG008680 United States HG NHGRI NIH HHS; UL1-TR-001420 United States TR NCATS NIH HHS; N01 HC085086 United States HL NHLBI NIH HHS; R01 HL085251 United States HL NHLBI NIH HHS; AA009367 United States AA NIAAA NIH HHS; N01 HC085083 United States HL NHLBI NIH HHS; DK063491 United States DK NIDDK NIH HHS; R01 AG030146 United States AG NIA NIH HHS; G0700931 United Kingdom MRC_ Medical Research Council; U01HL54527 United States HL NHLBI NIH HHS; U19 HL065962 United States HL NHLBI NIH HHS; R01CA15847 United States CA NCI NIH HHS; 1K08HG010155 United States HG NHGRI NIH HHS; U01HG004798 United States HG NHGRI NIH HHS; U01 HL054509 United States HL NHLBI NIH HHS; 75N92020D00001 United States HL NHLBI NIH HHS; U01 CA176726 United States CA NCI NIH HHS; U01AG023749 United States AG NIA NIH HHS; RO1 MH58799-03 United States MH NIMH NIH HHS; U01HG008664 United States HG NHGRI NIH HHS; U01 HG011719 United States HG NHGRI NIH HHS; CA098758 United States CA NCI NIH HHS; UM1CA167552 United States CA NCI NIH HHS; U01 CA188392 United States CA NCI NIH HHS; U01HG008673 United States HG NHGRI NIH HHS; 212945/Z/18/Z United Kingdom WT_ Wellcome Trust; R01 DK118427 United States DK NIDDK NIH HHS; R01 HL113338 United States HL NHLBI NIH HHS; HHSN268201100046C United States HL NHLBI NIH HHS; R01HL24799 United States HL NHLBI NIH HHS; N01-HC-95160 United States HL NHLBI NIH HHS; U01HG004438 United States HG NHGRI NIH HHS; Z01CP010119 United States CA NCI NIH HHS; R01NS032830 United States NS NINDS NIH HHS; R01 HL153805 United States HL NHLBI NIH HHS; R01 DK072193 United States DK NIDDK NIH HHS; P30AG72975 United States AG NIA NIH HHS; R01AG056477 United States AG NIA NIH HHS; R01 HL142302 United States HL NHLBI NIH HHS; R01-AG028050 United States AG NIA NIH HHS; AA-09203 United States AA NIAAA NIH HHS; R01 HL074166 United States HL NHLBI NIH HHS; S10 RR025141 United States RR NCRR NIH HHS; UL1RR024975 United States RR NCRR NIH HHS; R01 DK110113 United States DK NIDDK NIH HHS; R37 HL045508 United States HL NHLBI NIH HHS; R01 CA144034 United States CA NCI NIH HHS; R01AG30146 United States AG NIA NIH HHS; R01 HL086694 United States HL NHLBI NIH HHS; R35 HL135824 United States HL NHLBI NIH HHS; R01-NR012459 United States NR NINR NIH HHS; R01 DK104371 United States DK NIDDK NIH HHS; R01 AA013326 United States AA NIAAA NIH HHS; K02AA018755 United States AA NIAAA NIH HHS; HL54496 United States HL NHLBI NIH HHS; R01HD074711 United States HD NICHD NIH HHS; N01-HC-95167 United States HL NHLBI NIH HHS; HHSN268201100003C United States WH WHI NIH HHS; 1U19 CA148537 United States CA NCI NIH HHS; R01 AG065357 United States AG NIA NIH HHS; EY014684-03S1 United States EY NEI NIH HHS; N01 HC095167 United States HL NHLBI NIH HHS; R01 DK107786 United States DK NIDDK NIH HHS; R56 DA012854 United States DA NIDA NIH HHS; R01 HL087652 United States HL NHLBI NIH HHS; R01HL111249 United States HL NHLBI NIH HHS; AA13320 United States AA NIAAA NIH HHS; HL54495 United States HL NHLBI NIH HHS; U01 HG007376 United States HG NHGRI NIH HHS; MC_UU_00011/1 United Kingdom MRC_ Medical Research Council; R01 AG017917 United States AG NIA NIH HHS; N01-AG-6-2103 United States AG NIA NIH HHS; R01-CA080122 United States CA NCI NIH HHS; MC_UU_12026/2 United Kingdom MRC_ Medical Research Council; R01 HL088457 United States HL NHLBI NIH HHS; R01-DK062370 United States DK NIDDK NIH HHS; R01-HL-60030 United States HL NHLBI NIH HHS; T32 HG002295 United States HG NHGRI NIH HHS; U01HG008657 United States HG NHGRI NIH HHS; U01 HG004402 United States HG NHGRI NIH HHS; R01 DK075787 United States DK NIDDK NIH HHS; RR020649 United States RR NCRR NIH HHS; N01-HD-1-3331 United States HD NICHD NIH HHS; R01 AA009203 United States AA NIAAA NIH HHS; R01 CA49449 United States CA NCI NIH HHS; R01 AG034454 United States AG NIA NIH HHS; U01HG004402 United States HG NHGRI NIH HHS; R01DK075787 United States DK NIDDK NIH HHS; HL 046389 United States HL NHLBI NIH HHS; R01 EY022310 United States EY NEI NIH HHS; HL54473 United States HL NHLBI NIH HHS; U01HL54498 United States HL NHLBI NIH HHS; MC_UU_00019/1 United Kingdom MRC_ Medical Research Council; N01-HC65234 United States HL NHLBI NIH HHS; R01 NS100178 United States NS NINDS NIH HHS; U01HG006378 United States HG NHGRI NIH HHS; R35HL135818 United States HL NHLBI NIH HHS; 1U19 CA148112 United States CA NCI NIH HHS; U24 MH068457-06 United States MH NIMH NIH HHS; U01HG007376 United States HG NHGRI NIH HHS; 5K08HL135275 United States HL NHLBI NIH HHS; R01 TW005596 United States TW FIC NIH HHS; R01 NR012459 United States NR NINR NIH HHS; 75N92020D00003 United States HL NHLBI NIH HHS; N02-HL-6-4278 United States HL NHLBI NIH HHS; MC_PC_20026 United Kingdom MRC_ Medical Research Council; R01 DK092127-04 United States DK NIDDK NIH HHS; HHSN268201800014C United States HL NHLBI NIH HHS; N01 HC095159 United States HL NHLBI NIH HHS; U01 HL054464 United States HL NHLBI NIH HHS; 1RO1HL092577 United States HL NHLBI NIH HHS; P20 RR020649 United States RR NCRR NIH HHS; G0601966 United Kingdom MRC_ Medical Research Council; N01-HC65235 United States HL NHLBI NIH HHS; MC_UU_12015/1 United Kingdom MRC_ Medical Research Council; R01 CA056678 United States CA NCI NIH HHS; R01 HL119443 United States HL NHLBI NIH HHS; U01AG61256 United States AG NIA NIH HHS; U01HG007416 United States HG NHGRI NIH HHS; R01 DK087914 United States DK NIDDK NIH HHS; 75N92021D00001 United States HL NHLBI NIH HHS; U01 DK105535 United States DK NIDDK NIH HHS; N01-HG-65403 United States HG NHGRI NIH HHS; NR013520 United States NR NINR NIH HHS; K25 HL150334 United States HL NHLBI NIH HHS; R01 DK062370 United States DK NIDDK NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS; R01DK110113 United States DK NIDDK NIH HHS; HHSN268201200008C United States HL NHLBI NIH HHS; U19 CA055075 United States CA NCI NIH HHS; UM1CA182910 United States CA NCI NIH HHS; UL1TR001878 United States TR NCATS NIH HHS; HL129982 United States HL NHLBI NIH HHS; R01 AA013321 United States AA NIAAA NIH HHS; N01-HC-95163 United States HL NHLBI NIH HHS; T32 HL129982 United States HL NHLBI NIH HHS; R01 MH058799 United States MH NIMH NIH HHS; U01 HG008672 United States HG NHGRI NIH HHS; R01 HL108427 United States HL NHLBI NIH HHS; R35 HL135818 United States HL NHLBI NIH HHS; R01 CA128978 United States CA NCI NIH HHS; U01 DK062418 United States DK NIDDK NIH HHS; R01 HG011052 United States HG NHGRI NIH HHS; DA036216 United States DA NIDA NIH HHS; N01-HD-1-3329 United States HD NICHD NIH HHS; HHSN268201800003I United States HL NHLBI NIH HHS; U01 HG008684 United States HG NHGRI NIH HHS; HHSN268200782096C United States HG NHGRI NIH HHS; U01HG008672 United States HG NHGRI NIH HHS; R01HL085251 United States HL NHLBI NIH HHS; N01 HC065234 United States HL NHLBI NIH HHS; MC_PC_14135 United Kingdom MRC_ Medical Research Council; DA044283 United States DA NIDA NIH HHS; UL1-TR-001079 United States TR NCATS NIH HHS; N01-HC-25195 United States HL NHLBI NIH HHS; P30 DK063491 United States DK NIDDK NIH HHS; N01-HD-1-3228 United States HD NICHD NIH HHS; R01-DK122503 United States DK NIDDK NIH HHS; EP-C-15-001 United States EPA EPA; R01 CA064277 United States CA NCI NIH HHS; HHSN268201800007I United States HL NHLBI NIH HHS; HHSN268201700002C United States HL NHLBI NIH HHS; R01 DK066358 United States DK NIDDK NIH HHS; P30 AG010161 United States AG NIA NIH HHS; P30 DK072488 United States DK NIDDK NIH HHS; HHSN268201800001C United States HL NHLBI NIH HHS; U01 HG008679 United States HG NHGRI NIH HHS; R01 EY014684 United States EY NEI NIH HHS; CA128978 United States CA NCI NIH HHS; 263 MD 821336 United States MD NIMHD NIH HHS; IK2 CX001780 United States CX CSRD VA; AA10248 United States AA NIAAA NIH HHS; R35 CA053890 United States CA NCI NIH HHS; R01 DA042755 United States DA NIDA NIH HHS; HHSN268201200036C United States HL NHLBI NIH HHS; HL54471 United States HL NHLBI NIH HHS; R01-HL046380 United States HL NHLBI NIH HHS; R01 DK101855 United States DK NIDDK NIH HHS; N01-HC-95168 United States HL NHLBI NIH HHS; HL54515 United States HL NHLBI NIH HHS; HHSN268201700001I United States HL NHLBI NIH HHS; R01 HD056465 United States HD NICHD NIH HHS; U19 CA148537 United States CA NCI NIH HHS; IK2 CX001907 United States CX CSRD VA; P01 CA87969 United States CA NCI NIH HHS; N01 HC025195 United States HL NHLBI NIH HHS; R01-CA056678 United States CA NCI NIH HHS; HHSN268201800013I United States MD NIMHD NIH HHS; Z01 AG000513 United States ImNIH Intramural NIH HHS; U01 NS069208 United States NS NINDS NIH HHS; U01 AG023749 United States AG NIA NIH HHS; UL1TR002243 United States TR NCATS NIH HHS; UL1RR025005 United States RR NCRR NIH HHS; N01 HC055222 United States HL NHLBI NIH HHS; EY022310 United States EY NEI NIH HHS; DA005147 United States DA NIDA NIH HHS; U01HG004446 United States HG NHGRI NIH HHS; U01 HL054457 United States HL NHLBI NIH HHS; R01HL142302 United States HL NHLBI NIH HHS; ZIA CP010152 United States ImNIH Intramural NIH HHS; HHSN271201100004C United States AG NIA NIH HHS; HHSN268201700004I United States HL NHLBI NIH HHS; CA063464 United States CA NCI NIH HHS; AA-00145 United States AA NIAAA NIH HHS; R01 HL151152 United States HL NHLBI NIH HHS; R01 CA055069 United States CA NCI NIH HHS; N01-HC65236 United States HL NHLBI NIH HHS; U01 HG008666 United States HG NHGRI NIH HHS; R01 CA063464 United States CA NCI NIH HHS; DK125187 United States DK NIDDK NIH HHS; HHSN268201500001I United States HL NHLBI NIH HHS; 75N92021D00003 United States WH WHI NIH HHS; N.1-AG-1-1 United States AG NIA NIH HHS; R01 HD074711 United States HD NICHD NIH HHS; U01 AG023755 United States AG NIA NIH HHS; UM1 CA186107 United States CA NCI NIH HHS; N01 HC085079 United States HL NHLBI NIH HHS; R01 HD100406 United States HD NICHD NIH HHS; R01DK107786 United States DK NIDDK NIH HHS; R01 NS114045 United States NS NINDS NIH HHS; U01 HL054498 United States HL NHLBI NIH HHS; R01HL111249-04S1 United States HL NHLBI NIH HHS; D43 TW009077 United States TW FIC NIH HHS; K05 CA175147 United States CA NCI NIH HHS; RC2 GM092618 United States GM NIGMS NIH HHS; U01-DK105535 United States DK NIDDK NIH HHS; 1RC2MH089951-01 United States MH NIMH NIH HHS; R01HL087652 United States HL NHLBI NIH HHS; U01HG008684 United States HG NHGRI NIH HHS; R01HL087641 United States HL NHLBI NIH HHS; AA014041 United States AA NIAAA NIH HHS; R01HL105756 United States HL NHLBI NIH HHS; R01 CA67262 United States CA NCI NIH HHS; K02 AA018755 United States AA NIAAA NIH HHS; S10OD017985 United States NH NIH HHS; U01HG008666 United States HG NHGRI NIH HHS; HHSN268201100002C United States WH WHI NIH HHS; UL1 TR001420 United States TR NCATS NIH HHS; UL1TR000445 United States TR NCATS NIH HHS; CA054281 United States CA NCI NIH HHS; 75N92020D00004 United States HL NHLBI NIH HHS; EY014684 United States EY NEI NIH HHS; R01 CA082664 United States CA NCI NIH HHS; U24 MH068457 United States MH NIMH NIH HHS; UM1 CA182913 United States CA NCI NIH HHS; U01HG008701 United States HG NHGRI NIH HHS; 1Z01-HG000024 United States HG NHGRI NIH HHS; 1RC2 MH089995 United States MH NIMH NIH HHS; 75N92020D00007 United States HL NHLBI NIH HHS; R01 DA012854 United States DA NIDA NIH HHS; MC_UU_00017/1 United Kingdom MRC_ Medical Research Council; R01 CA054281 United States CA NCI NIH HHS; R01AG023629 United States AG NIA NIH HHS; KL2 RR024990 United States RR NCRR NIH HHS; U01 CA063464 United States CA NCI NIH HHS; P50 GM115305 United States GM NIGMS NIH HHS; N01 HC095163 United States HL NHLBI NIH HHS; HHSN268201800011C United States HL NHLBI NIH HHS; HL54472 United States HL NHLBI NIH HHS; U01 DP003206 United States DP NCCDPHP CDC HHS; 1X01HG006934-01 United States HG NHGRI NIH HHS; K05 AA000145 United States AA NIAAA NIH HHS; U01 NS069208-01 United States NS NINDS NIH HHS; R01 AG028050 United States AG NIA NIH HHS; TW005596 United States TW FIC NIH HHS; N01-AG-6-2106 United States AG NIA NIH HHS; N01-HC-95162 United States HL NHLBI NIH HHS; R01-CA092579 United States CA NCI NIH HHS; UM1CA182913 United States CA NCI NIH HHS; R01-DK072193 United States DK NIDDK NIH HHS; R01 CA128813 United States CA NCI NIH HHS; U19 AG063893 United States AG NIA NIH HHS; U54 MD007593 United States MD NIMHD NIH HHS; M01 RR007122 United States RR NCRR NIH HHS; R01 CA047988 United States CA NCI NIH HHS; KL2 TR002490 United States TR NCATS NIH HHS; R01CA144034 United States CA NCI NIH HHS; R01-HL 067974 United States HL NHLBI NIH HHS; HHSN268201500003I United States HL NHLBI NIH HHS; U01HG004423 United States HG NHGRI NIH HHS; R01CA64277 United States CA NCI NIH HHS; R01 HD058886 United States HD NICHD NIH HHS; 75N92021D00006 United States HL NHLBI NIH HHS; 5-P60-AR49465 United States AR NIAMS NIH HHS; HHSN268201700005C United States HL NHLBI NIH HHS; U01 HG008680 United States HG NHGRI NIH HHS; T32HL129982 United States HL NHLBI NIH HHS; R01HL151152 United States HL NHLBI NIH HHS; R01 HL080467 United States HL NHLBI NIH HHS; AA-12502 United States AA NIAAA NIH HHS; N01-HD-1-3333 United States HD NICHD NIH HHS; R01 HL085144 United States HL NHLBI NIH HHS; R01 DK089256 United States DK NIDDK NIH HHS; U19 CA148112 United States CA NCI NIH HHS; U01 HG006378 United States HG NHGRI NIH HHS; R01 DK124097 United States DK NIDDK NIH HHS; R01 AA012502 United States AA NIAAA NIH HHS; U01HG006379 United States HG NHGRI NIH HHS; Z01 CP010119 United States ImNIH Intramural NIH HHS; U01AG009740 United States AG NIA NIH HHS; R01 DA037904 United States DA NIDA NIH HHS; R01HG010297 United States HG NHGRI NIH HHS; R01 CA080205 United States CA NCI NIH HHS; R01-HL113338 United States HL NHLBI NIH HHS; N01-HC-95164 United States HL NHLBI NIH HHS; AA13321 United States AA NIAAA NIH HHS; HHSN268201700001C United States HL NHLBI NIH HHS; U01 HG004436 United States HG NHGRI NIH HHS; R01 NS105150 United States NS NINDS NIH HHS; UM1 CA167552 United States CA NCI NIH HHS; P30-CA015704 United States CA NCI NIH HHS; HHSN268201700003C United States HL NHLBI NIH HHS; R01HL103612 United States HL NHLBI NIH HHS; R01 HL086718 United States HL NHLBI NIH HHS; U01 AG023746 United States AG NIA NIH HHS; ZIA CP010152-20 United States CA NCI NIH HHS; K24HL105780 United States HL NHLBI NIH HHS; R35 CA53890 United States CA NCI NIH HHS; R01DK118427 United States DK NIDDK NIH HHS; K08 HL135275 United States HL NHLBI NIH HHS; R01 HG010067 United States HG NHGRI NIH HHS; K05-CA175147 United States CA NCI NIH HHS; HHSN268201800015I United States HB NHLBI NIH HHS; U01 HL054481 United States HL NHLBI NIH HHS; P30 DK056350 United States DK NIDDK NIH HHS; U01 CA098758 United States CA NCI NIH HHS; R01 HL09135701 United States HL NHLBI NIH HHS; U19 CA148065 United States CA NCI NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; HHSN268201700004C United States HL NHLBI NIH HHS; R01 DK092127 United States DK NIDDK NIH HHS; R21DK105913 United States DK NIDDK NIH HHS; RF1AG15819 United States AG NIA NIH HHS; 1U19 CA148065 United States CA NCI NIH HHS; R01 AA015416 United States AA NIAAA NIH HHS; R01 NS032830 United States NS NINDS NIH HHS; R03 HL154284 United States HL NHLBI NIH HHS; R01 DK053591 United States DK NIDDK NIH HHS; R01 DK125187 United States DK NIDDK NIH HHS; R01-HL074166 United States HL NHLBI NIH HHS; U01HG008685 United States HG NHGRI NIH HHS; UL1 TR000040 United States TR NCATS NIH HHS; RC2 AG036495 United States AG NIA NIH HHS; UL1 RR024975 United States RR NCRR NIH HHS; X01HG007492 United States HG NHGRI NIH HHS; R21 DK105913 United States DK NIDDK NIH HHS; HL043851 United States HL NHLBI NIH HHS; U10 HL054473 United States HL NHLBI NIH HHS; HHSN268201100003I United States HL NHLBI NIH HHS; N01-HC-95165 United States HL NHLBI NIH HHS; U01 HG008673 United States HG NHGRI NIH HHS; U19 CA 148537-01 United States CA NCI NIH HHS; UL1 TR000077 United States TR NCATS NIH HHS; R01DK101855 United States DK NIDDK NIH HHS; U10 HL054495 United States HL NHLBI NIH HHS; R01AG17917 United States AG NIA NIH HHS; U01 HG008685 United States HG NHGRI NIH HHS; N.1-AG-1-2111 United States AG NIA NIH HHS; MC_UU_00006/1 United Kingdom MRC_ Medical Research Council; R01 HL077398 United States HL NHLBI NIH HHS; U01 HG004423 United States HG NHGRI NIH HHS; U10 HL054496 United States HL NHLBI NIH HHS; U01 HG004798 United States HG NHGRI NIH HHS; R01 CA049449 United States CA NCI NIH HHS; HL54509 United States HL NHLBI NIH HHS; HHSN268201100002I United States HL NHLBI NIH HHS; R01 HL157635 United States HL NHLBI NIH HHS; U01HL130114 United States HL NHLBI NIH HHS; N01 HC095166 United States HL NHLBI NIH HHS; HHSN268201700002I United States HL NHLBI NIH HHS; R01HL117078 United States HL NHLBI NIH HHS; HHSN268201800010I United States HB NHLBI NIH HHS; HHSN268201700005I United States HL NHLBI NIH HHS; 263 MD 9164 United States MD NIMHD NIH HHS; UL1 TR002243 United States TR NCATS NIH HHS; R01-HL088457 United States HL NHLBI NIH HHS; R01-HG003054 United States HG NHGRI NIH HHS; U10 HL054471 United States HL NHLBI NIH HHS; AA13326 United States AA NIAAA NIH HHS; R01 CA080122 United States CA NCI NIH HHS; N01 HC095162 United States HL NHLBI NIH HHS; U01 HG006379 United States HG NHGRI NIH HHS; 75N92020D00006 United States HL NHLBI NIH HHS; R01 HL117078 United States HL NHLBI NIH HHS; DA12854 United States DA NIDA NIH HHS; EY014684-04S1 United States EY NEI NIH HHS; R01 HL095056 United States HL NHLBI NIH HHS; R01 HL087641 United States HL NHLBI NIH HHS; R01 AG023629 United States AG NIA NIH HHS; U01 HL054512 United States HL NHLBI NIH HHS; U01 HG008664 United States HG NHGRI NIH HHS; HHSN268201800011I United States HB NHLBI NIH HHS; HHSN268201800005I United States HL NHLBI NIH HHS; UM1 CA182910 United States CA NCI NIH HHS; T32 HL007055 United States HL NHLBI NIH HHS; RC2GM092618 United States GM NIGMS NIH HHS; HL085144 United States HL NHLBI NIH HHS; N01 HC095165 United States HL NHLBI NIH HHS; CA047988 United States CA NCI NIH HHS; AA15416 United States AA NIAAA NIH HHS; R37 DA005147 United States DA NIDA NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS; R01 CA092579 United States CA NCI NIH HHS; R01 CA55069 United States CA NCI NIH HHS; 202802/Z/16/Z United Kingdom WT_ Wellcome Trust; R01 NS45012 United States NS NINDS NIH HHS; HG011052 United States HG NHGRI NIH HHS; N01 HC095164 United States HL NHLBI NIH HHS; RG/17/1/32663 United Kingdom BHF_ British Heart Foundation; DK093757 United States DK NIDDK NIH HHS; HHSN268201800006I United States HL NHLBI NIH HHS; U01 HL054495 United States HL NHLBI NIH HHS; U01 CA164973 United States CA NCI NIH HHS; MR/S019669/1 United Kingdom MRC_ Medical Research Council; R37 CA054281 United States CA NCI NIH HHS; 75N92021D00004 United States WH WHI NIH HHS; HHSN268201100001C United States WH WHI NIH HHS; N01 HC065237 United States HL NHLBI NIH HHS; UM1 CA182883 United States CA NCI NIH HHS; HHSN268201700003I United States HL NHLBI NIH HHS; U01AG023712 United States AG NIA NIH HHS; CA164973 United States CA NCI NIH HHS; R01 HG010297 United States HG NHGRI NIH HHS; HHSN271201200022C United States DA NIDA NIH HHS; HHSN268201200008I United States HL NHLBI NIH HHS; N01 HC085081 United States HL NHLBI NIH HHS; HHSN268201100004C United States WH WHI NIH HHS; N01-AG-6-2101 United States AG NIA NIH HHS; R01-DK075787 United States DK NIDDK NIH HHS; K07 AG061256 United States AG NIA NIH HHS; U01HG008679 United States HG NHGRI NIH HHS; R01AG034454 United States AG NIA NIH HHS; R01 CA141298 United States CA NCI NIH HHS; R01 HL149683 United States HL NHLBI NIH HHS; U01 HL054473 United States HL NHLBI NIH HHS; R01 AG015819 United States AG NIA NIH HHS; R01-NS100178 United States NS NINDS NIH HHS; R01 DK078150 United States DK NIDDK NIH HHS; R01 DA044283 United States DA NIDA NIH HHS; P01CA055075 United States CA NCI NIH HHS; R01CA128813 United States CA NCI NIH HHS; U01 HG008701 United States HG NHGRI NIH HHS; DK078150 United States DK NIDDK NIH HHS; UL1-TR-000040 United States TR NCATS NIH HHS; R01HL086694 United States HL NHLBI NIH HHS; R01 AG056477 United States AG NIA NIH HHS; UM1 CA182876 United States CA NCI NIH HHS; U01HG008676 United States HG NHGRI NIH HHS; N01 HC095160 United States HL NHLBI NIH HHS; R01 AA013320 United States AA NIAAA NIH HHS; K08 HG010155 United States HG NHGRI NIH HHS; K01 HL135405 United States HL NHLBI NIH HHS; MC_PC_13049 United Kingdom MRC_ Medical Research Council; R01-HL-55005 United States HL NHLBI NIH HHS; R01 HL77398 United States HL NHLBI NIH HHS; N01-HC-95169 United States HL NHLBI NIH HHS; N01-HC-95161 United States HL NHLBI NIH HHS; R37 AA012502 United States AA NIAAA NIH HHS; HL080467 United States HL NHLBI NIH HHS; R01 DK122503 United States DK NIDDK NIH HHS; MH081802 United States MH NIMH NIH HHS |
| Contributed Indexing: | Investigator: GC Partida; Y Sun; D Croteau-Chonka; JM Vonk; S Chanock; L Le Marchand |
| Entry Date(s): | Date Created: 20221012 Date Completed: 20221102 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9605867 |
| DOI: | 10.1038/s41586-022-05275-y |
| PMID: | 36224396 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't