Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps.
| Title: | Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps. |
|---|---|
| Authors: | Dolete G; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Motelica L; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Ficai D; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry, and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; Oprea OC; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry, and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania.; Gheorghe M; SC NANOMEMS SRL, George Coșbuc 9, 505400 Râșnov, Romania.; Center for Technological Electronics and Interconnection Techniques, University Politehnica of Bucharest, Bulevardul Iuliu Maniu, 061071 Bucharest, Romania.; Ficai A; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania. |
| Source: | Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Oct 13; Vol. 12 (20). Date of Electronic Publication: 2022 Oct 13. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101610216 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4991 (Print) Linking ISSN: 20794991 NLM ISO Abbreviation: Nanomaterials (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2011]- |
| Abstract: | Given the demanding use of controlled drug delivery systems, our attention was focused on developing a magnetic film that can be triggered in the presence of a magnetic field for both drug delivery and the actuating mechanism in micropump biomedical microelectromechanical systems (BioMEMS). Magnetic alginate films were fabricated in three steps: the co-precipitation of iron salts in an alkaline environment to obtain magnetite nanoparticles (Fe3O4), the mixing of the obtained nanoparticles with a sodium alginate solution containing glycerol as a plasticizer and folic acid as an active substance, and finally the casting of the final solution in a Petri dish followed by cross-linking with calcium chloride solution. Magnetite nanoparticles were incorporated in the alginate matrix because of the well-established biocompatibility of both materials, a property that would make the film convenient for implantable BioMEMS devices. The obtained film was analyzed in terms of its magnetic, structural, and morphological properties. To demonstrate the hypothesis that the magnetic field can be used to trigger drug release from the films, we studied the release profile in an aqueous medium (pH = 8) using a NdFeB magnet as a triggering factor. |
| Competing Interests: | The authors declare no conflict of interest. |
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| Grant Information: | 522PED/2018 Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii |
| Contributed Indexing: | Keywords: BioMEMs; drug delivery; magnetic polymer thick films; magneto-mechanical triggering |
| Entry Date(s): | Date Created: 20221027 Latest Revision: 20221030 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9607447 |
| DOI: | 10.3390/nano12203598 |
| PMID: | 36296787 |
| Database: | MEDLINE |
Journal Article