Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future.
| Title: | Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future. |
|---|---|
| Authors: | Ahmed A; Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.; Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.; Lippner E; Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.; Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.; Khanolkar A; Department of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.; Department of Pathology, Northwestern University, Chicago, IL 60611, USA. |
| Source: | Cells [Cells] 2022 Oct 24; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 24. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| MeSH Terms: | Immunologic Deficiency Syndromes* ; B-Lymphocytes*; Humans |
| Abstract: | B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once considered incurable. Evaluating patients with primary immunodeficiency diseases (PID)/inborn errors of immunity (IEI) that primarily affect B cells, offers us an opportunity to further our understanding of how B cells develop, mature, function and, in certain instances, cause further disease. In this review we provide a brief compendium of IEI that principally affect B cells at defined stages of their developmental pathway, and also attempt to offer some educated viewpoints on how the management of these disorders could evolve over the years. |
| Competing Interests: | The authors declare no conflict of interest. |
| References: | Clin Immunol. 2019 Jan;198:19-30. (PMID: 30439505); Front Immunol. 2021 Jul 15;12:708837. (PMID: 34335625); Rev Med Suisse. 2021 Jan 13;17(720-1):68-76. (PMID: 33443835); Front Immunol. 2011 May 04;2:12. (PMID: 22566803); Orphanet J Rare Dis. 2018 Nov 12;13(1):201. (PMID: 30419968); Am J Hum Genet. 2015 Sep 3;97(3):389-403. (PMID: 26279205); N Engl J Med. 1954 Jun 17;250(24):1027-9. (PMID: 13165949); Pediatr Allergy Immunol. 2017 Aug;28(5):498-500. (PMID: 28517432); J Allergy Clin Immunol. 2017 Apr;139(4):1282-1292. (PMID: 27697500); Nature. 1975 Aug 7;256(5517):495-7. (PMID: 1172191); Front Immunol. 2019 Jul 19;10:1272. (PMID: 31379802); Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5056-61. (PMID: 17360404); J Pediatr (Rio J). 2021 Mar-Apr;97 Suppl 1:S17-S23. (PMID: 33181112); Gene. 2013 Aug 10;525(2):174-81. (PMID: 23566838); J Allergy Clin Immunol. 2022 Feb;149(2):736-746. (PMID: 34111452); Nature. 2022 Feb;602(7897):503-509. (PMID: 35110735); J Clin Immunol. 1998 Jul;18(4):283-90. (PMID: 9710745); J Clin Immunol. 2020 Jan;40(1):24-64. (PMID: 31953710); Front Plant Sci. 2016 Jan 11;6:1200. (PMID: 26793201); JAMA Pediatr. 2022 Feb 1;176(2):176-184. (PMID: 34779842); Nat Med. 1998 May;4(5):601-6. (PMID: 9585235); Scand J Immunol. 2018 Aug;88(2):e12699. (PMID: 29943473); Nat Med. 2014 Dec;20(12):1410-1416. (PMID: 25329329); Clin Diagn Lab Immunol. 2003 Mar;10(2):202-7. (PMID: 12626443); Front Pediatr. 2019 Aug 08;7:295. (PMID: 31440487); Hum Immunol. 2019 Jun;80(6):351-362. (PMID: 30359632); J Exp Med. 2021 Jul 5;218(7):. (PMID: 33951726); Hum Gene Ther. 2021 Jan;32(1-2):43-51. (PMID: 32935622); Front Immunol. 2016 Jun 13;7:220. (PMID: 27379089); Clin Exp Immunol. 2014 Dec;178 Suppl 1:83-5. (PMID: 25546772); Int J Pediatr Otorhinolaryngol. 1997 Mar 6;39(2):103-10. (PMID: 9104618); J Clin Immunol. 2021 Aug;41(6):1403-1405. (PMID: 33948812); J Allergy Clin Immunol. 2015 Apr;135(4):988-997.e6. (PMID: 25595268); N Engl J Med. 1988 Jul 7;319(1):1-7. (PMID: 3288866); Swiss Med Wkly. 2020 Jun 24;150:w20254. (PMID: 32579701); Vaccine. 2012 Jul 6;30(32):4717-8. (PMID: 22621828); Lancet. 1993 Mar 13;341(8846):701-2. (PMID: 8095616); Front Immunol. 2020 Aug 11;11:2004. (PMID: 32849664); Immunol Rev. 2021 Mar;300(1):82-99. (PMID: 33331000); Cell. 1993 Jan 29;72(2):279-90. (PMID: 8425221); J Allergy Clin Immunol. 2020 Aug;146(2):429-437. (PMID: 32169379); Clin Immunol. 2021 Aug;229:108779. (PMID: 34116213); Blood. 2012 Feb 16;119(7):1650-7. (PMID: 22180439); Sci Immunol. 2022 Mar 25;7(69):eabi7160. (PMID: 35333544); Clin Exp Immunol. 2013 Nov;174(2):203-11. (PMID: 23859429); Blood Adv. 2022 Apr 12;6(7):2444-2451. (PMID: 34920454); J Allergy Clin Immunol. 2016 Jan;137(1):223-230. (PMID: 26768763); J Exp Med. 2021 Dec 6;218(12):. (PMID: 34694366); J Clin Invest. 2013 Oct;123(10):4283-93. (PMID: 24051380); BMC Res Notes. 2014 Aug 26;7:566. (PMID: 25155248); Br J Haematol. 2021 Jun;193(6):1044-1059. (PMID: 33336808); J Allergy Clin Immunol. 2012 Sep;130(3 Suppl):S1-24. (PMID: 22935624); J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1763-1770. (PMID: 30776527); CRISPR J. 2021 Apr;4(2):191-206. (PMID: 33876953); Blood. 2020 Feb 27;135(9):656-667. (PMID: 31942606); J Immunol Methods. 2018 Oct;461:37-43. (PMID: 30098317); J Clin Immunol. 2021 Oct;41(7):1574-1581. (PMID: 34164761); Eur J Pediatr. 1998 Sep;157(9):735-7. (PMID: 9776532); Science. 2014 Sep 26;345(6204):1623-1627. (PMID: 25213377); J Investig Allergol Clin Immunol. 2013;23(2):120-4. (PMID: 23654079); J Allergy Clin Immunol. 2009 Oct;124(4):658-64. (PMID: 19665769); J Allergy Clin Immunol. 2011 Jul;128(1):223-225.e2. (PMID: 21397315); Pharmacology. 2021;106(1-2):9-19. (PMID: 32950975); Immunotherapy. 2014;6(10):1113-26. (PMID: 25428649); P T. 2014 Nov;39(11):746-72. (PMID: 25395816); J Allergy Clin Immunol Pract. 2020 Jan;8(1):283-291.e1. (PMID: 31430592); J Biol Chem. 2003 Jul 11;278(28):26258-64. (PMID: 12724322); MAbs. 2022 Jan-Dec;14(1):2014296. (PMID: 35030985); J Clin Immunol. 2020 Jan;40(1):66-81. (PMID: 32048120); Front Immunol. 2020 Feb 07;11:149. (PMID: 32117289); Asian Pac J Allergy Immunol. 2021 Mar;39(1):31-34. (PMID: 30447657); J Exp Med. 2021 Nov 1;218(11):. (PMID: 34473196); Blood. 2017 Nov 23;130(21):2307-2316. (PMID: 28972011); J Immunol. 1999 Jun 1;162(11):6690-700. (PMID: 10352287); Front Immunol. 2018 May 14;9:694. (PMID: 29867917); J Allergy Clin Immunol. 2009 Dec;124(6):1161-78. (PMID: 20004777); Neurol Neuroimmunol Neuroinflamm. 2020 Jun 4;7(4):. (PMID: 32499327); J Clin Immunol. 2021 Apr;41(3):666-679. (PMID: 33598806); J Biol Chem. 2013 Feb 8;288(6):4085-94. (PMID: 23250751); J Immunol. 1994 Jan 15;152(2):557-65. (PMID: 8283037); Emerg Infect Dis. 1999 Jan-Feb;5(1):54-64. (PMID: 10081672); Immunol Allergy Clin North Am. 2020 Aug;40(3):461-470. (PMID: 32654692); Blood. 2021 Jan 21;137(3):349-363. (PMID: 32845957); Front Pediatr. 2021 Aug 05;9:702872. (PMID: 34422726); J Clin Immunol. 2017 Aug;37(6):592-602. (PMID: 28755066); J Exp Med. 2003 Jun 16;197(12):1603-11. (PMID: 12810683); Curr Pharm Biotechnol. 2003 Feb;4(1):51-67. (PMID: 12570682); Acta Cytol. 2001 Mar-Apr;45(2):241-4. (PMID: 11284311); Nat Immunol. 2021 Jul;22(7):893-903. (PMID: 34155405); Medicine (Baltimore). 2017 Dec;96(49):e8989. (PMID: 29245273); J Clin Immunol. 2022 Oct;42(7):1473-1507. (PMID: 35748970); Hum Mol Genet. 2019 Oct 1;28(R1):R15-R23. (PMID: 31297531); Genes Dis. 2019 Jul 30;7(1):38-51. (PMID: 32181274); Nature. 1993 Jan 21;361(6409):226-33. (PMID: 8380905); Front Immunol. 2013 Jul 12;4:185. (PMID: 23874333); Science. 2011 Apr 29;332(6029):600-3. (PMID: 21474713); Sci Immunol. 2021 Nov 26;6(65):eabe3454. (PMID: 34826260); Immunol Allergy Clin North Am. 2019 Feb;39(1):129-140. (PMID: 30466769); J Clin Immunol. 2019 Oct;39(7):726-738. (PMID: 31432443); J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59. (PMID: 26563668); J Allergy Clin Immunol. 2020 Oct;146(4):901-911. (PMID: 32278790); J Allergy Clin Immunol. 2018 Dec;142(6):1932-1946. (PMID: 29729943); Sci Rep. 2019 May 10;9(1):7239. (PMID: 31076587) |
| Contributed Indexing: | Keywords: B cells; humoral immunity; immunodeficiency; inborn errors of immunity |
| Entry Date(s): | Date Created: 20221111 Date Completed: 20221116 Latest Revision: 20240907 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9654110 |
| DOI: | 10.3390/cells11213353 |
| PMID: | 36359748 |
| Database: | MEDLINE |
Journal Article; Review; Research Support, Non-U.S. Gov't