Magnetite Microspheres for the Controlled Release of Rosmarinic Acid.
| Title: | Magnetite Microspheres for the Controlled Release of Rosmarinic Acid. |
|---|---|
| Authors: | Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Pîrvulescu DC; Faculty of Medical Engineering, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Academy of Romanian Scientists, 54 Spl. Independentei, 050045 Bucharest, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Academy of Romanian Scientists, 54 Spl. Independentei, 050045 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania. |
| Source: | Pharmaceutics [Pharmaceutics] 2022 Oct 26; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 26. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Abstract: | Since cancer incidence is constantly increasing, novel and more efficient treatment methods that overcome the current limitations of chemotherapy are continuously explored. In this context, the aim of the present study was to investigate the potential of two types of magnetite microspheres as drug delivery vehicles for the controlled release of rosmarinic acid (RA) in anticancer therapies. The magnetite microspheres were obtained through the solvothermal method by using polyethylene glycol (PEG) with two different molecular weights as the surfactant. The physicochemical characterization of the so-obtained drug delivery carriers involved X-ray diffraction (XRD) coupled with Rietveld refinement, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and zeta potential, and UV-Vis spectrophotometry. The magnetite-based anticancer agents were biologically evaluated through the ROS-Glo H2O2 and MTT assays. Results proved the formation of magnetite spheres with submicronic sizes and the effective RA loading and controlled release, while the biological assays demonstrated the anticancer potential of the present systems. Thus, this study successfully developed a promising drug delivery alternative based on magnetite that could be used in the continuous fight against cancer. |
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| Contributed Indexing: | Keywords: anticancer; magnetite; natural biocompounds; polyethylene glycol; polyphenols; rosmarinic acid |
| Entry Date(s): | Date Created: 20221111 Latest Revision: 20221128 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9693273 |
| DOI: | 10.3390/pharmaceutics14112292 |
| PMID: | 36365111 |
| Database: | MEDLINE |
Journal Article