Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala.
| Title: | Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
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| Authors: | Paniagua-Avila A; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States of America.; Olson D; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado, United States of America.; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America.; Connery A; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Department of Rehabilitation Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America.; Calvimontes DM; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Bolanos GA; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States of America.; Lamb MM; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States of America.; Bauer D; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States of America.; Ralda A; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Rojop N; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Barrios E; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Chacon A; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Gomez M; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Arroyave P; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Hernandez S; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Martinez MA; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Bunge-Montes S; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Colbert A; Department of Rehabilitation Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America.; Arias K; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Brazeale G; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado, United States of America.; Holliday A; Emmes Company, LLC, Rockville, Maryland, United States of America.; Tomashek KM; Emmes Company, LLC, Rockville, Maryland, United States of America.; El Sahly HM; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.; Keitel W; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.; Munoz FM; Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America.; Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America.; Asturias EJ; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, Retalhuleu, Guatemala.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado, United States of America.; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America. |
| Source: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Nov 16; Vol. 16 (11), pp. e0010480. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Pregnancy Complications, Infectious*/epidemiology ; Zika Virus Infection* ; Zika Virus*; Guatemala/epidemiology ; Infant ; Child ; Female ; Humans ; Child, Preschool ; Pregnancy ; Cohort Studies ; Prospective Studies |
| Abstract: | During the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly recognized neurotropic flavivirus could affect the developing brain of infants and young children infected after birth. We report here the study design, methods and the challenges and lessons learned from the rapid operationalization of a prospective natural history cohort study aimed at evaluating the potential neurological and neurodevelopmental effects of postnatal ZIKV infection in infants and young children, which had become epidemic in Central America. This study enrolled a cohort of 500 mothers and their infants, along with nearly 400 children 1.5-3.5 years of age who were born during the initial phase of the ZIKV epidemic in a rural area of Guatemala. Our solutions and lessons learned while tackling real-life challenges may serve as a guide to other researchers carrying out studies of emerging infectious diseases of public health priority in resource-constrained settings.; (Copyright: © 2022 Paniagua-Avila et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Grant Information: | HHSN272201300015C United States AI NIAID NIH HHS; HHSN272201300015I United States AI NIAID NIH HHS; K23 AI143967 United States AI NIAID NIH HHS; UL1 RR025780 United States RR NCRR NIH HHS |
| Entry Date(s): | Date Created: 20221116 Date Completed: 20221202 Latest Revision: 20250513 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9710790 |
| DOI: | 10.1371/journal.pntd.0010480 |
| PMID: | 36383617 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural