Estimation of anti-orthopoxvirus immunity in Moscow residents and potential risks of spreading Monkeypox virus.
| Title: | Estimation of anti-orthopoxvirus immunity in Moscow residents and potential risks of spreading Monkeypox virus. |
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| Authors: | Gushchin VA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.; Ogarkova DA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Dolzhikova IV; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Zubkova OV; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Grigoriev IV; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Pochtovyi AA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.; Iliukhina AA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Ozharovskaia TA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Kuznetsova NA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Kustova DD; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Shelkov AY; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Zrelkin DI; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Odintsova AS; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Grousova DM; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Kan VY; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Davtyan SA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Siniavin AE; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Belyaeva ED; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Botikov AG; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Bessonova AA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Vasilchenko LA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Vasina DV; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Kleymenov DA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Slutskiy EA; Moscow Healthcare Department, Moscow, Russia.; Tkachuk AP; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Burgasova OA; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Moscow Healthcare Department, Moscow, Russia.; Department of Infectious Diseases with the Courses of Epidemiology and Phthisiology, Peoples Friendship University of Russia (RUDN) University, Moscow, Russia.; Loginova SY; Department of Especially Dangerous Viral Infections, 48-Central Research Institute of the Ministry of Defence of the Russian Federation, Moscow, Russia.; Rozhdestvensky EV; Department of Especially Dangerous Viral Infections, 48-Central Research Institute of the Ministry of Defence of the Russian Federation, Moscow, Russia.; Shcheblyakov DV; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Tsibin AN; Moscow Healthcare Department, Moscow, Russia.; Komarov AG; Moscow Healthcare Department, Moscow, Russia.; Zlobin VI; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Borisevich SV; Department of Especially Dangerous Viral Infections, 48-Central Research Institute of the Ministry of Defence of the Russian Federation, Moscow, Russia.; Naroditsky BS; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Logunov DY; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Gintsburg AL; Department of Science, Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. |
| Source: | Frontiers in immunology [Front Immunol] 2022 Nov 16; Vol. 13, pp. 1023164. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation] |
| MeSH Terms: | Orthopoxvirus* ; Mpox, Monkeypox* ; Communicable Diseases*; Moscow/epidemiology ; Humans ; Adult ; Middle Aged ; Monkeypox virus ; Cross-Sectional Studies ; Vaccinia virus ; Antibodies, Neutralizing |
| Abstract: | WHO has declared the outbreak of monkeypox as a public health emergency of international concern. In less than three months, monkeypox was detected in more than 30 000 people and spread to more than 80 countries around the world. It is believed that the immunity formed to smallpox vaccine can protect from monkeypox infection with high efficiency. The widespread use of Vaccinia virus has not been carried out since the 1980s, which raises the question of the level of residual immunity among the population and the identification of groups requiring priority vaccination. We conducted a cross-sectional serological study of remaining immunity among Moscow residents. To do this, a collection of blood serum samples of age group over 30 years old was formed, an in-house ELISA test system was developed, and a virus neutralization protocol was set up. Serum samples were examined for the presence of IgG antibodies against Vaccinia virus (n=2908), as well as for the ability to neutralize plaque formation with a Vaccinia virus MNIIVP-10 strain (n=299). The results indicate the presence of neutralizing antibody titer of 1/20 or more in 33.3 to 53.2% of people older than 45 years. Among people 30-45 years old who probably have not been vaccinated, the proportion with virus neutralizing antibodies ranged from 3.2 to 6.7%. Despite the higher level of antibodies in age group older than 66 years, the proportion of positive samples in this group was slightly lower than in people aged 46-65 years. The results indicate the priority of vaccination in groups younger than 45, and possibly older than 66 years to ensure the protection of the population in case of spread of monkeypox among Moscow residents. The herd immunity level needed to stop the circulation of the virus should be at least 50.25 - 65.28%.; (Copyright © 2022 Gushchin, Ogarkova, Dolzhikova, Zubkova, Grigoriev, Pochtovyi, Iliukhina, Ozharovskaia, Kuznetsova, Kustova, Shelkov, Zrelkin, Odintsova, Grousova, Kan, Davtyan, Siniavin, Belyaeva, Botikov, Bessonova, Vasilchenko, Vasina, Kleymenov, Slutskiy, Tkachuk, Burgasova, Loginova, Rozhdestvensky, Shcheblyakov, Tsibin, Komarov, Zlobin, Borisevich, Naroditsky, Logunov and Gintsburg.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: immunity; monkeypox virus (MPXV); neutralizing antibody titers (NAT); orthopoxvirus; vaccinia virus (VACV) |
| Substance Nomenclature: | 0 (Antibodies, Neutralizing) |
| Entry Date(s): | Date Created: 20221205 Date Completed: 20221206 Latest Revision: 20250103 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9709467 |
| DOI: | 10.3389/fimmu.2022.1023164 |
| PMID: | 36466896 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't