Chitosan-Dextran-Glycerol Hydrogels Loaded with Iron Oxide Nanoparticles for Wound Dressing Applications.
| Title: | Chitosan-Dextran-Glycerol Hydrogels Loaded with Iron Oxide Nanoparticles for Wound Dressing Applications. |
|---|---|
| Authors: | Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Bejenaru IT; Faculty of Medical Engineering, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Nicoară AI; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Oprea OC; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 1-7 Polizu St., 011061 Bucharest, Romania.; Tihăuan B; Research Institute of the University of Bucharest-ICUB, 91-95 Splaiul Independentei, 50567 Bucharest, Romania.; Research & Development for Advanced Biotechnologies and Medical Devices, SC Sanimed International Impex SRL, 087040 Călugăreni, Romania. |
| Source: | Pharmaceutics [Pharmaceutics] 2022 Nov 28; Vol. 14 (12). Date of Electronic Publication: 2022 Nov 28. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Abstract: | Natural polymers have shown tremendous potential towards the development of hydrogels with tissue regeneration properties. Among them, chitosan and dextran are polysaccharides widely applied in the wound dressing area owing to their mucoadhesiveness, biodegradability, hemostatic potential, and intrinsic antibacterial activity, while glycerol is a well-known biocompatible solvent extensively used in the manufacture of cosmetic, pharmaceutical, medical, and personal care products. In order to enhance the properties of natural polymer-based hydrogels, the focus has currently shifted towards the addition of nanomaterials with antibacterial and regenerative potential, i.e., iron oxide nanoparticles. Thus, the aim of the present study was to develop a series of chitosan-dextran-glycerol hydrogels loaded with iron oxide nanoparticles, either readily added or formed in situ. The physicochemical properties of the so obtained hydrogels demonstrated an improved dispersibility of the in situ formed magnetite nanoparticles, which further decreases the porosity and swelling ratio of the hydrogels but increases the antimicrobial properties. Additionally, the presence of glycerol enhances the cell viability but reduces the antimicrobial potential. In this context, the results proved promising biological and antimicrobial properties, thus confirming their potential as biomaterials for wound healing and regeneration. |
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| Grant Information: | PD75/2022 Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii |
| Contributed Indexing: | Keywords: chitosan; dextran; glycerol; hydrogels; iron oxide nanoparticles; wound dressings |
| Entry Date(s): | Date Created: 20221223 Latest Revision: 20221226 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9784071 |
| DOI: | 10.3390/pharmaceutics14122620 |
| PMID: | 36559114 |
| Database: | MEDLINE |
Journal Article