Functional Neurological Disorder-Old Problem New Perspective.
| Title: | Functional Neurological Disorder-Old Problem New Perspective. |
|---|---|
| Authors: | Perjoc RS; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; Roza E; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; Vladacenco OA; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; Teleanu DM; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Emergency University Hospital, 050098 Bucharest, Romania.; Neacsu R; 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania.; Teleanu RI; 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Dr. Victor Gomoiu' Children's Hospital, 022102 Bucharest, Romania. |
| Source: | International journal of environmental research and public health [Int J Environ Res Public Health] 2023 Jan 08; Vol. 20 (2). Date of Electronic Publication: 2023 Jan 08. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel : MDPI, c2004- |
| MeSH Terms: | Nervous System Diseases*/diagnosis ; Nervous System Diseases*/therapy ; Conversion Disorder*/diagnosis ; Conversion Disorder*/psychology ; Conversion Disorder*/therapy; Young Adult ; Humans ; Child ; Adolescent ; Magnetic Resonance Imaging |
| Abstract: | Functional neurological disorder (FND) is a common issue in the pediatric population. The concept and our understanding of functional neurological disorders have changed over the past years, and new etiologic models and treatment plans have been explored. Knowledge about FND in the pediatric population, however, is lacking. The aim of this review is to provide an update on pediatric functional neurological disorder. We conducted a literature search of PubMed and SCOPUS databases and reviewed a total of 85 articles to gain insight into the current understanding of FND etiology, diagnosis, treatment, and prognosis in children and adolescents. Functional and high resolution MRI revealed abnormal connectivity and structural changes in patients with functional symptoms. The diagnostic criteria no longer require the presence of a psychological factor and instead focus on a rule-in diagnosis. Treatment of FND includes a clear communication of the diagnosis and the support of a multidisciplinary team. Although FND typically has a poor prognosis, better outcomes appear to have been achieved in children and young adults. We conclude that pediatric functional neurological disorder is a prevalent pathology and that this patient population has additional specific needs compared to the adult population. |
| References: | Neurol Sci. 2021 Oct;42(10):3989-3990. (PMID: 34324120); Neurology. 2010 Jan 19;74(3):223-8. (PMID: 20083798); JAMA Neurol. 2018 Sep 1;75(9):1132-1141. (PMID: 29868890); BMJ. 2005 Oct 29;331(7523):989. (PMID: 16223792); Epilepsia. 2012 Feb;53(2):377-85. (PMID: 22150750); J Neurol Neurosurg Psychiatry. 2015 Oct;86(10):1113-9. (PMID: 25433033); Epilepsy Behav. 2012 Jan;23(1):7-9. (PMID: 22093246); CNS Spectr. 2020 Sep 04;:1-7. (PMID: 32883381); J Am Acad Child Adolesc Psychiatry. 2007 Jan;46(1):68-75. (PMID: 17195731); Epilepsy Res Treat. 2011;2011:274736. (PMID: 22937230); Seizure. 2021 Dec;93:20-31. (PMID: 34656015); Epilepsia Open. 2017 Sep 01;2(4):467-471. (PMID: 29588977); Mov Disord. 2008 Oct 15;23(13):1875-81. (PMID: 18709677); Epilepsia. 1998 Jul;39(7):749-52. (PMID: 9670904); Epilepsy Behav. 2018 Dec;89:70-78. (PMID: 30384103); Epilepsia. 2021 Jul;62(7):1528-1535. (PMID: 34075579); Epilepsia. 2013 Nov;54(11):2005-18. (PMID: 24111933); Ann Clin Transl Neurol. 2020 Aug;7(8):1410-1419. (PMID: 32748572); Epilepsy Behav. 2020 Apr;105:106971. (PMID: 32126506); J Affect Disord. 2018 Apr 1;230:65-70. (PMID: 29407540); Am J Psychiatry. 1996 Jan;153(1):57-63. (PMID: 8540592); Epilepsy Behav. 2015 Dec;53:168-73. (PMID: 26580213); Clin Psychol Rev. 2007 Oct;27(7):798-820. (PMID: 17728032); Neurobiol Dis. 2019 Jul;127:32-44. (PMID: 30798005); Handb Clin Neurol. 2017;139:489-498. (PMID: 27719866); J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):220-6. (PMID: 24029543); Innov Clin Neurosci. 2015 May-Jun;12(5-6):27-33. (PMID: 26155375); Epilepsia. 2013 Oct;54(10):1715-24. (PMID: 23944981); Br J Psychiatry. 2013 Jun;202:413-8. (PMID: 23620449); J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):E37-8. (PMID: 21948923); Epilepsy Behav. 2012 Nov;25(3):345-9. (PMID: 23103308); J Psychiatry Neurosci. 2019 Jan 01;44(1):8-18. (PMID: 30565902); Dev Med Child Neurol. 2008 Apr;50(4):300-4. (PMID: 18312601); Pediatr Neurol. 2014 Aug;51(2):233-8. (PMID: 25079572); Ind Psychiatry J. 2020 Jul-Dec;29(2):222-227. (PMID: 34158705); J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):227-9. (PMID: 24039028); Epilepsia. 2017 Jul;58(7):1123-1130. (PMID: 28464309); BMJ. 2022 Jan 24;376:o64. (PMID: 35074803); J Neurol Neurosurg Psychiatry. 2022 Mar;93(3):339-340. (PMID: 34408004); Epilepsy Behav. 2007 Nov;11(3):409-12. (PMID: 17905668); J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):609-616. (PMID: 35217516); Epilepsy Behav. 2020 Jan;102:106667. (PMID: 31846898); Eur J Neurol. 2021 May;28(5):1752-1758. (PMID: 33300269); Epilepsy Behav. 2016 Aug;61:180-184. (PMID: 27362440); Neuroimage Clin. 2017 May 06;15:306-314. (PMID: 28560155); Dialogues Clin Neurosci. 2018 Mar;20(1):23-31. (PMID: 29946208); Seizure. 2003 Dec;12(8):561-7. (PMID: 14630494); Vaccine. 2020 Oct 7;38(43):6714-6720. (PMID: 32878709); Psychoneuroendocrinology. 2017 Nov;85:142-150. (PMID: 28863348); Eur J Paediatr Neurol. 2019 Mar;23(2):317-328. (PMID: 30594458); Epilepsy Behav. 2016 Sep;62:62-5. (PMID: 27450307); J Clin Psychiatry. 2005 Dec;66(12):1529-34. (PMID: 16401153); Neurology. 2002 Feb 12;58(3):493-5. (PMID: 11839862); Innov Clin Neurosci. 2019 Jul 01;16(7-08):18-21. (PMID: 31832259); Clin Child Psychol Psychiatry. 2021 Oct;26(4):1196-1207. (PMID: 34353136); Handb Clin Neurol. 2017;139:523-541. (PMID: 27719869); J Neurol Neurosurg Psychiatry. 1989 Apr;52(4):439-46. (PMID: 2786923); J Neuropsychiatry Clin Neurosci. 2020 Fall;32(4):389-395. (PMID: 32718273); Neurology. 2016 Aug 9;87(6):564-70. (PMID: 27385746); Mov Disord Clin Pract. 2019 Dec 24;7(2):182-187. (PMID: 32071937); Arch Intern Med. 2010 Sep 27;170(17):1525-32. (PMID: 20876402); Clin Exp Vaccine Res. 2017 Jan;6(1):31-37. (PMID: 28168171); JAMA Psychiatry. 2014 Jan;71(1):52-60. (PMID: 24258270); J Neurol Neurosurg Psychiatry. 2017 Jun;88(6):484-490. (PMID: 27694498); Neurology. 2010 Sep 28;75(13):1166-73. (PMID: 20739647); Epilepsia. 2010 Jan;51(1):70-8. (PMID: 19453708); Clin Psychol Rev. 2006 Dec;26(8):1020-40. (PMID: 16472897); Neurol Clin Pract. 2021 Oct;11(5):e686-e690. (PMID: 34840884); Lancet Psychiatry. 2018 Apr;5(4):307-320. (PMID: 29526521); Psychiatry Clin Neurosci. 2022 Nov;76(11):595-596. (PMID: 35946916); J Neurol Neurosurg Psychiatry. 1997 Jul;63(1):83-8. (PMID: 9221972); Psychosomatics. 1998 Nov-Dec;39(6):519-27. (PMID: 9819952); J Neuropsychiatry Clin Neurosci. 2021 Fall;33(4):345-348. (PMID: 34261345); J Lifestyle Med. 2020 Jan 31;10(1):1-6. (PMID: 32328443); J Clin Psychol Med Settings. 2021 Mar;28(1):90-101. (PMID: 32743729); Front Psychiatry. 2019 Jan 10;9:762. (PMID: 30687141); Am J Psychiatry. 1999 Nov;156(11):1796-800. (PMID: 10553745); J Neurol. 2020 Jul;267(7):2164-2172. (PMID: 32193596); Behav Sci (Basel). 2022 Mar 08;12(3):. (PMID: 35323390); Neurologist. 2013 Jan;19(1):30-3. (PMID: 23269105); Neurology. 2003 May 13;60(9):1501-7. (PMID: 12743239); Seizure. 2012 May;21(4):282-7. (PMID: 22425423); J Psychosom Res. 2009 May;66(5):383-90. (PMID: 19379954) |
| Contributed Indexing: | Keywords: children; family; functional neurological disorder |
| Entry Date(s): | Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20231118 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9859618 |
| DOI: | 10.3390/ijerph20021099 |
| PMID: | 36673871 |
| Database: | MEDLINE |
Journal Article; Review