Review of antibiotic prescriptions as part of antimicrobial stewardship programmes: results from a pilot implementation at two provincial-level hospitals in Viet Nam.
| Title: | Review of antibiotic prescriptions as part of antimicrobial stewardship programmes: results from a pilot implementation at two provincial-level hospitals in Viet Nam. |
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| Authors: | Ngan TTD; National Hospital for Tropical Diseases, 78 Giai Phong, Hanoi, Viet Nam.; Hanoi Medical University, 1 Ton That Tung, Hanoi, Viet Nam.; Quan TA; Hanoi Group, Oxford University Clinical Research Unit, 78 Giai Phong, Viet Nam.; Quang LM; Viet Tiep Hospital, 1 Nha Thuong, Cat Dai, Le Chan, Hai Phong, Viet Nam.; Vinh VH; Viet Tiep Hospital, 1 Nha Thuong, Cat Dai, Le Chan, Hai Phong, Viet Nam.; Duc CM; Dong Thap Hospital, 144 Mai Van Khai, My Tan, Cao Lanh City, Đong Thap.; Nguyet HT; Dong Thap Hospital, 144 Mai Van Khai, My Tan, Cao Lanh City, Đong Thap.; Tu NTC; Hanoi Group, Oxford University Clinical Research Unit, 78 Giai Phong, Viet Nam.; Khanh NH; Hanoi Group, Oxford University Clinical Research Unit, 78 Giai Phong, Viet Nam.; Long LB; Viet Tiep Hospital, 1 Nha Thuong, Cat Dai, Le Chan, Hai Phong, Viet Nam.; Hue NH; Viet Tiep Hospital, 1 Nha Thuong, Cat Dai, Le Chan, Hai Phong, Viet Nam.; Hung DT; Viet Tiep Hospital, 1 Nha Thuong, Cat Dai, Le Chan, Hai Phong, Viet Nam.; Thanh ND; Viet Tiep Hospital, 1 Nha Thuong, Cat Dai, Le Chan, Hai Phong, Viet Nam.; Ve NV; Dong Thap Hospital, 144 Mai Van Khai, My Tan, Cao Lanh City, Đong Thap.; Giang TT; Dong Thap Hospital, 144 Mai Van Khai, My Tan, Cao Lanh City, Đong Thap.; Tung LT; Dong Thap Hospital, 144 Mai Van Khai, My Tan, Cao Lanh City, Đong Thap.; Tuan TT; Dong Thap Hospital, 144 Mai Van Khai, My Tan, Cao Lanh City, Đong Thap.; Kesteman T; Hanoi Group, Oxford University Clinical Research Unit, 78 Giai Phong, Viet Nam.; Dodds Ashley E; Duke Antimicrobial Stewardship Outreach Network, Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University, Durham, NC 27710, USA.; Anderson DJ; Duke Antimicrobial Stewardship Outreach Network, Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University, Durham, NC 27710, USA.; Van Doorn HR; Hanoi Group, Oxford University Clinical Research Unit, 78 Giai Phong, Viet Nam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.; Huong VTL; Hanoi Group, Oxford University Clinical Research Unit, 78 Giai Phong, Viet Nam. |
| Source: | JAC-antimicrobial resistance [JAC Antimicrob Resist] 2023 Jan 18; Vol. 5 (1), pp. dlac144. Date of Electronic Publication: 2023 Jan 18 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101765283 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1823 (Electronic) Linking ISSN: 26321823 NLM ISO Abbreviation: JAC Antimicrob Resist Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Oxford] : Oxford University Press, [2019]- |
| Abstract: | Objectives: To investigate the feasibility of retrospective prescription-based review and to describe the antibiotic prescribing patterns to provide information for an antimicrobial stewardship programme in Viet Nam.; Methods: This study was conducted in two provincial-level hospitals between February and April 2020. Reviews were done by a clinical team consisting of leaders/senior doctors of each ward to assess the optimal level (optimal/adequate/suboptimal/inadequate/not assessable) of antibiotic prescriptions. Mixed-effect logistic regression at prescription level was used to explore factors associated with optimal antibiotic use.; Results: The retrospective prescription-based review was accepted by study clinical wards with varied levels of participants. One hundred and eighty-three patients (326 prescriptions) in Hospital 1 and 200 patients (344 prescriptions) in Hospital 2 were included. One hundred and nineteen of the 326 (36.5%) antibiotic prescriptions in Hospital 1 and 51/344 (14.8%) antibiotic prescriptions in Hospital 2 were determined to be optimal by the review teams. The number of adequate antibiotic prescriptions were 179/326 (54.9%) and 178 (51.7%) in Hospital 1 and Hospital 2, respectively. The optimal level was lower for surgical prophylaxis antibiotics than for empirical therapy (OR = 0.06; 95% CI 0.01-0.45), higher in prescriptions in the ICU (OR = 12.00; 95% CI 3.52-40.92), higher in definitive antibiotic therapy (OR = 48.12; 95% CI 7.17-322.57) and higher in those with an indication recorded in medical records (OR = 3.46; 95% CI 1.13-10.62).; Conclusions: This study provides evidence on the feasibility of retrospective prescription-based review, with adaption to the local situation. High and varying levels of optimal antibiotic prescriptions in clinical wards in hospitals were observed in Viet Nam.; (© The Author(s) 2023. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.) |
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| Entry Date(s): | Date Created: 20230123 Latest Revision: 20240911 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9847554 |
| DOI: | 10.1093/jacamr/dlac144 |
| PMID: | 36686271 |
| Database: | MEDLINE |
Journal Article