Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry.
| Title: | Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry. |
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| Authors: | De Luca G; Division of Cardiology, AOU 'Policlinico G. Martino', Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.; Division of Cardiology, Nuovo Galeazzi-Sant'Ambrogio Hospital, 20161 Milan, Italy.; Manzo-Silberman S; ACTION Study Group, Institute of Cardiology-Hôpital Pitié-Salpêtrière (AP-HP), Sorbonne University, 75651 Paris, France.; Algowhary M; Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut 71515, Egypt.; Uguz B; Division of Cardiology, Bursa City Hospital, 16000 Bursa, Turkey.; Oliveira DC; Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife 50670-901, Brazil.; Ganyukov V; Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, 650000 Kemerovo, Russia.; Busljetik O; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, 1000 Skopje, North Macedonia.; Cercek M; Department of Cardiology, Medical Center Ljubljana, 1000 Ljubljana, Slovenia.; Okkels L; Division of Cardiology, Odense Universitets Hospital, 5000 Odense, Denmark.; Loh PH; Department of Cardiology, National University Hospital, Singapore 117597, Singapore.; Calmac L; Clinic Emergency Hospital of Bucharest, 014461 Bucharest, Romania.; Ferrer GRI; Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, 08016 Barcelona, Spain.; Quadros A; Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90040-371, Brazil.; Milewski M; Division of Cardiology, Medical University of Silezia, 40-002 Katowice, Poland.; Scotto di Uccio F; Division of Cardiology, Ospedale del Mare, 00156 Napoli, Italy.; von Birgelen C; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, 7541 Enschede, The Netherlands.; Versaci F; Division of Cardiology, Ospedale Santa Maria Goretti Latina, 04100 Latina, Italy.; Ten Berg J; Division of Cardiology, St. Antonius Hospital, 3434 Nieuwegein, The Netherlands.; Casella G; Division of Cardiology, Ospedale Maggiore Bologna, 40100 Bologna, Italy.; Wong Sung Lung A; Department of Cardiology, National Heart Center, Singapore 169609, Singapore.; Kala P; University Hospital Brno, Medical Faculty of Masaryk University, 60200 Brno, Czech Republic.; Díez Gil JL; Sección de la Unidad de Hemodinámica H. Universitario y Politécnico La Fe, 46001 Valencia, Spain.; Carrillo X; Hospital Germans Triasi Pujol, 8918 Badalona, Spain.; Dirksen M; Division of Cardiology, Northwest Clinics, 1811 Alkmaar, The Netherlands.; Becerra V; Hospital Clínico Universitario Virgen de la Victoria, 29000 Malaga, Spain.; Lee MK; Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong.; Juzar DA; Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center 'Harapan Kita', Jakarta 11420, Indonesia.; de Moura Joaquim R; Instituto de Cardiologia de Santa Catarina Praia Comprida, São José 88103-901, Brazil.; Paladino R; Division of Cardiology, Clinica Villa dei Fiori, 80011 Acerra, Italy.; Milicic D; Department of Cardiology, University Hospital Centre, University of Zagreb, 10000 Zagreb, Croatia.; Davlouros P; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, 26221 Patras, Greece.; Bakraceski N; Center for Cardiovascular Diseases, 6000 Ohrid, North Macedonia.; Zilio F; Division of Cardiology, Ospedale Santa Chiara di Trento, 38014 Trento, Italy.; Donazzan L; Division of Cardiology, Ospedale 'S. Maurizio' Bolzano, 39100 Bolzano, Italy.; Kraaijeveld A; Division of Cardiology, 3584 Utrecht, The Netherlands.; Galasso G; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, 84070 Salerno, Italy.; Arpad L; Maastricht University Medical Center, 6229 Maastricht, The Netherlands.; Marinucci L; Division of Cardiology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', 61121 Pesaro, Italy.; Guiducci V; Division of Cardiology, AUSL-IRCCS Reggio Emilia, 42121 Reggio Emilia, Italy.; Menichelli M; Division of Cardiology, Ospedale 'F. Spaziani', 03100 Frosinone, Italy.; Scoccia A; Division of Cardiology, Ospedale 'Sant'Anna', 44121 Ferrara, Italy.; Yamac AH; Department of Cardiology, Bezmialem Vakif University Hospital, 34093 Istanbul, Turkey.; Ugur Mert K; Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 02640 Eskisehir, Turkey.; Flores Rios X; Complexo Hospetaliero Universitario La Coruna, 15001 La Coruna, Spain.; Kovarnik T; University Hospital Prague, 12808 Prague, Czech Republic.; Kidawa M; Central Hospital of Medical University of Lodz, 90-008 Lodz, Poland.; Moreu J; Division of Cardiology, Complejo Hospitalario de Toledo, 45001 Toledo, Spain.; Flavien V; Division of Cardiology, Center Hospitalier Universitaire de Lille, 59000 Lille, France.; Fabris E; Azienda Ospedaliero-Universitaria Ospedali Riuniti, 34142 Trieste, Italy.; Martínez-Luengas IL; Division of Cardiology, Hospital Cabueñes, 33201 Gijon, Spain.; Boccalatte M; Division of Cardiology, Ospedale Santa Maria delle Grazie, 80078 Pozzuoli, Italy.; Ojeda FB; Division of Cardiology, Hospital Universitario de Canarias, 38001 Santa Cruz de Tenerife, Spain.; Arellano-Serrano C; Division of Cardiology, Hospital Puerta de Hierro Majadahonda, 28222 Majadahonda, Spain.; Caiazzo G; Division of Cardiology, Ospedale 'G Moscati', 81031 Aversa, Italy.; Cirrincione G; Division of Cardiology, Ospedale Civico Arnas, 90100 Palermo, Italy.; Kao HL; Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, Tapei 8865600, Taiwan.; Forés JS; Division of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain.; Vignali L; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, 43121 Parma, Italy.; Pereira H; Cardiology Department, Hospital Garcia de Orta, Pragal, 2805-267 Almada, Portugal.; Ordoñez S; Instituto Cardiovascular de Buenos Aires, Buenos Aires 1428, Argentina.; Arat Özkan A; Cardiology Institute, Istanbul University, 34000 Instanbul, Turkey.; Scheller B; Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, 66123 Saarbrücken, Germany.; Lehtola H; Division of Cardiology, Oulu University Hospital, 90220 Oulu, Finland.; Teles R; Division of Cardiology, Hospital de Santa Cruz, CHLO-Nova Medical School, CEDOC, 1000 Lisbon, Portugal.; Mantis C; Division of Cardiology, Kontantopoulion Hospital, 10431 Athens, Greece.; Antti Y; Division of Cardiology, Heart Centre Turku, 20521 Turku, Finland.; Brum Silveira JA; Division of Cardiology, Hospital de Santo António, 4099-001 Porto, Portugal.; Zoni CR; Department of Teaching and Research, Instituto de Cardiología de Corrientes 'Juana F. Cabral', Corrientes W3400CDS, Argentina.; Bessonov I; Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, 634000-634538 Tomsk, Russia.; Uccello G; Division of Cardiology, Ospedale 'A. Manzoni', 23900 Lecco, Italy.; Kochiadakis G; Iraklion University Hospital, 70001 Crete, Greece.; Alexopulos D; Division of Cardiology, Attikon University Hospital, 10431 Athens, Greece.; Uribe CE; Division of Cardiology, Universidad UPB, Universidad CES, Medellín 050001, Colombia.; Kanakakis J; Division of Cardiology, Alexandra Hospital, 10431 Athens, Greece.; Faurie B; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, 38000 Grenoble, France.; Gabrielli G; Interventional Cardiology Unit, Azienda Ospedaliero Universitaria'Ospedali Riuniti', 60100 Ancona, Italy.; Barrios AG; Division of Cardiology, Hospital Puerta del Mar, 11001 Cadiz, Spain.; Bachini JP; Instituto de Cardiologia Integral, Montevideo 11700, Uruguay.; Rocha A; Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo 11700, Uruguay.; Tam FCC; Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong.; Rodriguez A; Division of Cardiology, Otamendi Hospital, Buenos Aires 1001, Argentina.; Lukito AA; Cardiovascular Department Pelita Harapan University, Heart Center Siloam Lippo Village Hospital, Tangerang, Banten 15810, Indonesia.; Saint-Joy V; Center Hospitalier d'Antibes Juan Les Pins, 06600 Antibes, France.; Pessah G; Division of Cardiology, Hospiatl Cordoba, Cordoba 5000, Argentina.; Tuccillo A; Division of Cardiology, Ospedale del Mare, 00156 Napoli, Italy.; Ielasi A; Division of Cardiology, Nuovo Galeazzi-Sant'Ambrogio Hospital, 20161 Milan, Italy.; Cortese G; Department of Statistical Sciences, University of Padova, 35121 Padova, Italy.; Parodi G; Azienda Ospedaliera Lavagna, 16033 Lavagna, Italy.; Bouraghda MA; Division of Cardiology, Blida University Hospital, Blida 09000, Algeria.; Moura M; Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90040-371, Brazil.; Kedhi E; Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, 1070 Brussels, Belgium.; Lamelas P; Instituto Cardiovascular de Buenos Aires, Buenos Aires 1428, Argentina.; Suryapranata H; Division of Cardiology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.; Nardin M; Department of Internal Medicine, Ospedale Riuniti, 25121 Brescia, Italy.; Verdoia M; Division of Cardiology, Ospedale degli Infermi, ASL, 13900 Biella, Italy. |
| Source: | Journal of clinical medicine [J Clin Med] 2023 Jan 23; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 23. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
| Abstract: | Background: Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry.; Methods: This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March-June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality.; Results: We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825-0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31-2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96-1.34], p = 0.12).; Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655. |
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| Contributed Indexing: | Keywords: COVID-19; ST-segment elevation myocardial infarction; gender; percutaneous coronary intervention |
| Entry Date(s): | Date Created: 20230211 Latest Revision: 20230214 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9918240 |
| DOI: | 10.3390/jcm12030896 |
| PMID: | 36769546 |
| Database: | MEDLINE |
Journal Article