Subdural CMOS optical probe (SCOPe) for bidirectional neural interfacing.
| Title: | Subdural CMOS optical probe (SCOPe) for bidirectional neural interfacing. |
|---|---|
| Authors: | Pollmann EH; Yin H; Uguz I; Dubey A; Wingel KE; Choi JS; Moazeni S; Gilhotra Y; Pavlovsky VA; Banees A; Boominathan V; Robinson J; Veeraraghavan A; Pieribone VA; Pesaran B; Shepard KL |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 08. Date of Electronic Publication: 2023 Feb 08. |
| Publication Type: | Preprint; Journal Article |
| Language: | English |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Abstract: | Optical neurotechnologies use light to interface with neurons and can monitor and manipulate neural activity with high spatial-temporal precision over large cortical extents. While there has been significant progress in miniaturizing microscope for head-mounted configurations, these existing devices are still very bulky and could never be fully implanted. Any viable translation of these technologies to human use will require a much more noninvasive, fully implantable form factor. Here, we leverage advances in microelectronics and heterogeneous optoelectronic packaging to develop a transformative, ultrathin, miniaturized device for bidirectional optical stimulation and recording: the subdural CMOS Optical Probe (SCOPe). By being thin enough to lie entirely within the subdural space of the primate brain, SCOPe defines a path for the eventual human translation of a new generation of brain-machine interfaces based on light. |
| Entry Date(s): | Date Created: 20230217 Latest Revision: 20230217 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9934536 |
| DOI: | 10.1101/2023.02.07.527500 |
| PMID: | 36798295 |
| Database: | MEDLINE |
Preprint; Journal Article