Real-life therapeutic effects of beclomethasone dipropionate/formoterol fumarate/glycopyrronium combined triple therapy in patients with chronic obstructive pulmonary disease.
| Title: | Real-life therapeutic effects of beclomethasone dipropionate/formoterol fumarate/glycopyrronium combined triple therapy in patients with chronic obstructive pulmonary disease. |
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| Authors: | Pelaia C; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Viale Europa - Località Germaneto, 88100 Catanzaro, Italy.; Procopio G; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Rotundo FL; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Deodato MR; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Ferrante Bannera A; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Tropea FG; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Cancelliere A; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Vatrella A; Department of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, Italy.; Pelaia G; Department of Health Sciences, Campus Universitario 'S. Venuta', University 'Magna Græcia' of Catanzaro, Catanzaro, Italy. |
| Source: | Therapeutic advances in respiratory disease [Ther Adv Respir Dis] 2023 Jan-Dec; Vol. 17, pp. 17534666231155778. |
| Publication Type: | Observational Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: SAGE Publications Country of Publication: England NLM ID: 101316317 Publication Model: Print Cited Medium: Internet ISSN: 1753-4666 (Electronic) Linking ISSN: 17534658 NLM ISO Abbreviation: Ther Adv Respir Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, UK : SAGE Publications |
| MeSH Terms: | Beclomethasone*/adverse effects ; Pulmonary Disease, Chronic Obstructive*/diagnosis ; Pulmonary Disease, Chronic Obstructive*/drug therapy; Glycopyrrolate/adverse effects ; Humans ; Formoterol Fumarate ; Administration, Inhalation ; Bronchodilator Agents ; Drug Combinations |
| Abstract: | Background: The small airway disease has been recognized as a central feature of chronic obstructive pulmonary disease (COPD). Triple fixed combination beclomethasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) is provided as a pressurized single-dose inhaler based on an extra-fine formulation, which has been approved for patients with COPD experiencing frequent disease exacerbations.; Methods: The aim of our real-life single-center observational study was to investigate, in 22 patients with COPD, the effects of BDP/FF/G on lung function, respiratory symptoms, health status, and exacerbation rate. Several clinical and lung functional parameters were evaluated at baseline and after 12 months of treatment with combined inhaled triple therapy.; Results: With respect to baseline, after 12 months of treatment with BDP/FF/G, significant changes were recorded with regard to forced expiratory flow at 75% of forced vital capacity (FVC) (p |
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| Contributed Indexing: | Keywords: COPD; airway resistance; exacerbations; small airway disease; triple inhaled therapy |
| Substance Nomenclature: | W34SHF8J2K (Formoterol Fumarate); KGZ1SLC28Z (Beclomethasone); V92SO9WP2I (Glycopyrrolate); 0 (Bronchodilator Agents); 0 (Drug Combinations) |
| Entry Date(s): | Date Created: 20230227 Date Completed: 20230228 Latest Revision: 20240913 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9972048 |
| DOI: | 10.1177/17534666231155778 |
| PMID: | 36846944 |
| Database: | MEDLINE |
Observational Study; Journal Article