A genetic Study of the Ghanaian Population Using 15 Autosomal STR Loci.
| Title: | A genetic Study of the Ghanaian Population Using 15 Autosomal STR Loci. |
|---|---|
| Authors: | Kofi AE; Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia. abban.kofi@googlemail.com.; Forensic Science Laboratory, Criminal Investigation Department, Ghana Police Service, 00233, Accra, Ghana. abban.kofi@googlemail.com.; Agyemang DA; Forensic Science Laboratory, Criminal Investigation Department, Ghana Police Service, 00233, Accra, Ghana.; Ghansah A; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, 00233, Accra, Ghana.; Awandare GA; School of Biological Sciences, University of Ghana, Legon, 00233, Accra, Ghana.; Hakim HM; School of Industrial Technologies, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia.; DNA Databank Division (D13), Criminal Investigation Department, Royal Malaysian Police, 43200, Cheras, Selangor, Malaysia.; Khan HO; DNA Databank Division (D13), Criminal Investigation Department, Royal Malaysian Police, 43200, Cheras, Selangor, Malaysia.; Nur Haslindawaty AR; Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.; Aziz MY; Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200, Kepala Batas, Pulau Pinang, Malaysia.; Chambers GK; School of Biological Sciences, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.; Edinur HA; Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia. edinur@usm.my. |
| Source: | Biochemical genetics [Biochem Genet] 2023 Oct; Vol. 61 (5), pp. 1850-1866. Date of Electronic Publication: 2023 Mar 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : New York : Kluwer Academic/Plenum Publishers; Original Publication: New York, Plenum Press. |
| MeSH Terms: | Genetics, Population* ; Microsatellite Repeats*; Humans ; Ghana ; Polymerase Chain Reaction ; Gene Frequency ; DNA Fingerprinting |
| Abstract: | Autosomal short tandem repeat (STR) population data collected from a well characterized population are needed to correctly assigning the weight of DNA profiles in the courtroom and widely used for ancestral analyses. In this study, allele frequencies for the 15 autosomal short tandem repeat (STR) loci included in the AmpFlSTR® Identifiler® plus kit (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818, FGA) were obtained by genotyping 332 unrelated individuals of Ghanaian origin. Statistical tests on STR genotype data showed no significant departure from Hardy-Weinberg equilibrium (HWE). The overall match probability, combined power of exclusion and combined power of discrimination for these loci were 1 in 3.85 × 1017, 0.99999893 and 0.99999998, respectively. Polymorphic information content (PIC) greater than 0.70 was observed for all loci except TH01 and D13S317. These statistical parameters confirm that this combination of loci is valuable for forensic identification and parentage analysis. Our results were also compared with those for 20 other human populations analyzed for the same set of markers. We observed that the Ghanaian population grouped with other African populations in two-dimensional principal coordinate (PCO) and a neighbor-joining (N-J) data mapping and placed closest to Nigerians. This observation reflects cultural similarities and geographical factors, coupled with the long history of migration and trading activities between Ghana and Nigeria. Our report provides what we believe to be the first published autosomal STR data for the general Ghanaian population using 15 loci genotyped using the AmpFlSTR® Identifiler® plus kit methodology. Our data show that the loci tested have sufficient power to be used reliably for DNA profiling in forensic casework and help to elucidate the genetic history of people living in the country.; (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| Contributed Indexing: | Keywords: Ancestral analyses; Autosomal STR Ghana; Forensic DNA; Forensic parameters |
| Entry Date(s): | Date Created: 20230304 Date Completed: 20230925 Latest Revision: 20230925 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10528-023-10347-3 |
| PMID: | 36869999 |
| Database: | MEDLINE |
Journal Article