Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry.
| Title: | Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry. |
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| Authors: | De Luca G; Division of Cardiology, AOU Policlinico G Martino, 98124 Messina, Italy.; Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.; Division of Cardiology, Galeazzi-Sant'Ambrogio Hospital, 20157 Milan, Italy.; Algowhary M; Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut 71515, Egypt.; Uguz B; Division of Cardiology, Bursa City Hospital, 16110 Bursa, Türkiye.; Oliveira DC; Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife 1235, Brazil.; Ganyukov V; Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, 653002 Kemerovo, Russia.; Busljetik O; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, 1000 Skopje, North Macedonia.; Cercek M; Department of Cardiology, Medical Center Ljubljana, 1000 Ljubljana, Slovenia.; Jensen LO; Division of Cardiology, Odense Universitets Hospital, 5000 Odense, Denmark.; Loh PH; Department of Cardiology, National University Hospital, Singapore 119074, Singapore.; Calmac L; Clinic Emergency Hospital of Bucharest, 010001 Bucharest, Romania.; Ferrer GRI; Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, 08016 Barcelona, Spain.; Quadros A; Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90000-00, Brazil.; Milewski M; Division of Cardiology, Medical University of Silezia, 40-002 Katowice, Poland.; Scotto D'Uccio F; Division of Cardiology, Ospedale del Mare, 80147 Napoli, Italy.; von Birgelen C; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, 7541 Enschede, The Netherlands.; Versaci F; Division of Cardiology, Ospedale Santa Maria Goretti Latina, 04100 Latina, Italy.; Ten Berg J; Division of Cardiology, St Antonius Hospital, 3434 Nieuwegein, The Netherlands.; Casella G; Division of Cardiology, Ospedale Maggiore Bologna, 40100 Bologna, Italy.; Wong Sung Lung A; Department of Cardiology, National Heart Center, Singapore 169609, Singapore.; Kala P; University Hospital Brno, Medical Faculty of Masaryk University Brno, 60200 Bohunice, Czech Republic.; Díez Gil JL; Cardiology, H. Universitario y Politécnico La Fe, 46001 Valencia, Spain.; Carrillo X; Hospital Germans Triasi Pujol, 8918 Badalona, Spain.; Dirksen M; Division of Cardiology, Northwest Clinics, 1811 Alkmaar, The Netherlands.; Becerra Munoz V; Hospital Clínico Universitario Virgen de la Victoria, 290000 Malaga, Spain.; Lee MK; Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong.; Juzar DA; Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center 'Harapan Kita', Jakarta 11402, Indonesia.; de Moura Joaquim R; Instituto de Cardiologia de Santa Catarina Praia Comprida, São José 88100-000, Brazil.; Paladino R; Division of Cardiology, Clinica Villa dei Fiori, 80011 Acerra, Italy.; Milicic D; Department of Cardiology, University Hospital Centre, University of Zagreb, 10000 Zagreb, Croatia.; Davlouros P; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, 26221 Patras, Greece.; Bakraceski N; Center for Cardiovascular Diseases, 6000 Ohrid, North Macedonia.; Zilio F; Division of Cardiology, Ospedale Santa Chiara di Trento, 38014 Trento, Italy.; Donazzan L; Division of Cardiology, Ospedale 'S. Maurizio', 39100 Bolzano, Italy.; Kraaijeveld A; Division of Cardiology, UMC Utrecht, 3584 Utrecht, The Netherlands.; Galasso G; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggid'Aragona, 84070 Salerno, Italy.; Arpad L; Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.; Marinucci L; Division of Cardiology, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', 61121 Pesaro, Italy.; Guiducci V; Division of Cardiology, AUSL-IRCCS Reggio Emilia, 42121 Reggio Emilia, Italy.; Menichelli M; Division of Cardiology, Ospedale 'F. Spaziani', 03100 Frosinone, Italy.; Scoccia A; Division of Cardiology, Ospedale 'Sant'Anna', 44121 Ferrara, Italy.; Yamac AH; Department of Cardiology, Hospital Bezmialem Vakıf University, 34093 Istanbul, Türkiye.; Ugur Mert K; Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 02640 Eskisehir, Türkiye.; Flores Rios X; Complexo Hospetaliero Universitario La Coruna, 15001 La Coruna, Spain.; Kovarnik T; University Hospital Prague, 12808 Prague, Czech Republic.; Kidawa M; Central Hospital, Medical University of Lodz, 90-008 Lodz, Poland.; Moreu J; Division of Cardiology, Complejo Hospitalario de Toledo, 45001 Toledo, Spain.; Flavien V; Division of Cardiology, Center Hospitalier Universitaire de Lille, 59000 Lille, France.; Fabris E; Azienda Ospedaliero, Universitaria Ospedali Riuniti Trieste, 34142 Trieste, Italy.; Martínez-Luengas IL; Division of Cardiology, Hospital Cabueñes, 33201 Gijon, Spain.; Boccalatte M; Division of Cardiology, Ospedale Santa Maria delle Grazie, 80078 Pozzuoli, Italy.; Bosa Ojeda F; Division of Cardiology, Hospital Universitario de Canarias, 38001 Santa Cruz de Tenerife, Spain.; Arellano-Serrano C; Division of Cardiology, Hospital Puerta de Hierro Majadahonda, 28222 Madrid, Spain.; Caiazzo G; Division of Cardiology, Ospedale 'G Moscati', 81031 Aversa, Italy.; Cirrincione G; Division of Cardiology, Ospedale Civico Arnas, 90100 Palermo, Italy.; Kao HL; Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, 8865, Taipei 600, Taiwan.; Sanchis Forés J; Division of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain.; Vignali L; Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, 43121 Parma, Italy.; Pereira H; Cardiology Department, Hospital Garcia de Orta, Pragal, 2805-267 Almada, Portugal.; Manzo-Silberman S; Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, 75010 Paris, France.; Ordoñez S; Instituto Cardiovascular de Buenos Aires, 6302, Buenos Aires C1428 CABA, Argentina.; Arat Özkan A; Cardiology Institute, Instanbul University, 34000 Istanbul, Türkiye.; Scheller B; Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, 66421 Saarland, Germany.; Lehitola H; Division of Cardiology, Oulu University Hospital, 90220 Oulu, Finland.; Teles R; Division of Cardiology, Hospital de Santa Cruz, CHLO-Nova Medical School, 1000 Lisbon, Portugal.; Mantis C; Division of Cardiology, Kontantopoulion Hospital, 10431 Athens, Greece.; Antti Y; Division of Cardiology, Heart Centre Turku, 20521 Turku, Finland.; Brum Silveira JA; Division of Cardiology, Hospital de Santo António, 4099-001 Porto, Portugal.; Zoni CR; Department of Teaching and Research, Instituto de Cardiología de Corrientes 'Juana F. Cabral', Corrientes W3400CDS, Argentina.; Bessonov I; Tyumen Cardiology Research Center, 625026 Tyumen, Russia.; Uccello G; Division of Cardiology, Ospedale 'A. Manzoni', 23900 Lecco, Italy.; Kochiadakis G; Iraklion University Hospital, 70001 Crete, Greece.; Alexopulos D; Division of Cardiology, Attikon University Hospital, 10431 Athens, Greece.; Uribe CE; Division of Cardiology, Universidad UPB-CES, Medellin 050001, Colombia.; Kanakakis J; Division of Cardiology, Alexandra Hospital, 10431 Athens, Greece.; Faurie B; Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, 38000 Grenoble, France.; Gabrielli G; Interventional Cardiolgy Unit, IRCCS INRCA, 60131 Ancona, Italy.; Gutierrez Barrios A; Division of Cardiology, Hospital Puerta del Mar, 11001 Cadiz, Spain.; Bachini JP; Instituto de Cardiologia Integral, Montevideo 11700, Uruguay.; Rocha A; Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo 11700, Uruguay.; Tam FCC; Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong.; Rodriguez A; Division of Cardiology, Otamendi Hospital, Buenos Aires 1001, Argentina.; Lukito AA; Heart Center Siloam Lippo Village Hospital, Cardiovascular Department Pelita Harapan University, Tangerang 15810, Indonesia.; Saint-Joy V; Center Hospitalierd'Antibes Juan Les Pins, 06600 Antibes, France.; Pessah G; Division of Cardiology, Hospital Cordoba, Cordoba 5000, Argentina.; Tuccillo A; Division of Cardiology, Ospedale del Mare, 80147 Napoli, Italy.; Ielasi A; Division of Cardiology, Galeazzi-Sant'Ambrogio Hospital, 20157 Milan, Italy.; Cortese G; Department of Statistical Sciences, University of Padova, 35121 Padova, Italy.; Parodi G; Cardiology, Azienda Ospedaliera Lavagna, 16033 Lavagna, Italy.; Burgadha MA; Division of Cardiology, Blida University Hospital, Blida 0900, Algeria.; Kedhi E; Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, 1050 Bruxelles, Belgium.; Lamelas P; Instituto Cardiovascular de Buenos Aires, 6302, Buenos Aires C1428 CABA, Argentina.; Suryapranata H; Division of Cardiology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.; Nardin M; Department of Internal Medicine, Ospedale Riuniti, 25121 Brescia, Italy.; Verdoia M; Division of Cardiology, Ospedale degli Infermi, ASL, 13900 Biella, Italy. |
| Source: | Journal of clinical medicine [J Clin Med] 2023 Mar 08; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 08. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
| Abstract: | Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19.; Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality.; Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic.; Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. |
| References: | Eur Heart J. 2005 Apr;26(7):662-6. (PMID: 15681574); Circulation. 2020 Jun 23;141(25):2113-2116. (PMID: 32352306); J Am Coll Cardiol. 2020 Sep 15;76(11):1318-1324. (PMID: 32828614); J Thromb Haemost. 2016 Jan;14(1):57-64. (PMID: 26512550); N Engl J Med. 2020 Jul 30;383(5):496-498. (PMID: 32348640); J Thromb Thrombolysis. 2019 Oct;48(3):413-421. (PMID: 31065927); Tex Heart Inst J. 2007;34(1):11-8. (PMID: 17420787); Circulation. 2004 Mar 16;109(10):1223-5. (PMID: 15007008); Circulation. 2020 Jun 16;141(24):2035-2037. (PMID: 32352318); J Am Coll Cardiol. 2020 Jun 9;75(22):2871-2872. (PMID: 32283124); Eur Heart J. 2004 Jun;25(12):1009-13. (PMID: 15191770); Eur Heart J. 2020 Jun 7;41(22):2083-2088. (PMID: 32412631); Lancet Public Health. 2020 Aug;5(8):e437-e443. (PMID: 32473113); J Am Coll Cardiol. 2020 Nov 17;76(20):2321-2330. (PMID: 33183506); Circulation. 2020 Jun 16;141(24):1951-1953. (PMID: 32315205); Heart Vessels. 2014 Jan;29(1):15-20. (PMID: 23494604); N Engl J Med. 2020 Mar 26;382(13):1199-1207. (PMID: 31995857); Eur Heart J. 2018 Jan 7;39(2):119-177. (PMID: 28886621); Cardiovasc Diabetol. 2020 Dec 18;19(1):215. (PMID: 33339541); JAMA Cardiol. 2020 Jul 1;5(7):831-840. (PMID: 32219363); J Thromb Haemost. 2020 May;18(5):1094-1099. (PMID: 32220112); BMC Cardiovasc Disord. 2021 Jan 7;21(1):23. (PMID: 33413093); Circ Cardiovasc Qual Outcomes. 2020 Apr;13(4):e006631. (PMID: 32182131) |
| Contributed Indexing: | Keywords: COVID-19; ST-segment elevation myocardial infarction; ageing |
| Entry Date(s): | Date Created: 20230329 Latest Revision: 20230919 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10059932 |
| DOI: | 10.3390/jcm12062116 |
| PMID: | 36983119 |
| Database: | MEDLINE |
Journal Article