H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel® Promotes Diabetic Wound Healing.
| Title: | H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel® Promotes Diabetic Wound Healing. |
|---|---|
| Authors: | Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Niculescu AG; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Hildegard H; 'Aurel Ardelean' Institute of Life Sciences, 'Vasile Goldis' Western University of Arad, 310025 Arad, Romania.; Baltă C; 'Aurel Ardelean' Institute of Life Sciences, 'Vasile Goldis' Western University of Arad, 310025 Arad, Romania.; Roșu M; 'Aurel Ardelean' Institute of Life Sciences, 'Vasile Goldis' Western University of Arad, 310025 Arad, Romania.; Mladin B; 'Aurel Ardelean' Institute of Life Sciences, 'Vasile Goldis' Western University of Arad, 310025 Arad, Romania.; Gherasim O; Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania.; Mihaiescu DE; Department of Organic Chemistry, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Vasile BȘ; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Hermenean AO; 'Aurel Ardelean' Institute of Life Sciences, 'Vasile Goldis' Western University of Arad, 310025 Arad, Romania. |
| Source: | Pharmaceutics [Pharmaceutics] 2023 Mar 06; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 06. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Abstract: | Hydrogel-based dressings exhibit suitable features for successful wound healing, including flexibility, high water-vapor permeability and moisture retention, and exudate absorption capacity. Moreover, enriching the hydrogel matrix with additional therapeutic components has the potential to generate synergistic results. Thus, the present study centered on diabetic wound healing using a Matrigel-enriched alginate hydrogel embedded with polylactic acid (PLA) microspheres containing hydrogen peroxide (H2O2). The synthesis and physicochemical characterization of the samples, performed to evidence their compositional and microstructural features, swelling, and oxygen-entrapping capacity, were reported. For investigating the three-fold goal of the designed dressings (i.e., releasing oxygen at the wound site and maintaining a moist environment for faster healing, ensuring the absorption of a significant amount of exudate, and providing biocompatibility), in vivo biological tests on wounds of diabetic mice were approached. Evaluating multiple aspects during the healing process, the obtained composite material proved its efficiency for wound dressing applications by accelerating wound healing and promoting angiogenesis in diabetic skin injuries. |
| References: | J Biomed Mater Res A. 2008 May;85(2):397-407. (PMID: 17688245); Biomater Res. 2022 Oct 1;26(1):50. (PMID: 36183134); Semin Cancer Biol. 2005 Oct;15(5):378-86. (PMID: 15975825); J Biomed Mater Res B Appl Biomater. 2020 Apr;108(3):1097-1106. (PMID: 31393674); Pharmaceutics. 2022 Feb 04;14(2):. (PMID: 35214091); Int J Surg Case Rep. 2021 May;82:105931. (PMID: 33962267); Int J Nanomedicine. 2019 Jul 18;14:5449-5475. (PMID: 31409998); Polymers (Basel). 2021 Aug 06;13(16):. (PMID: 34451151); ScientificWorldJournal. 2018 Aug 12;2018:6425857. (PMID: 30158840); Int Wound J. 2022 Dec;19(8):2200-2209. (PMID: 35510518); J Adv Res. 2017 May;8(3):217-233. (PMID: 28239493); Int J Nanomedicine. 2020 May 18;15:3511-3522. (PMID: 32547010); Int J Biol Macromol. 2018 Jul 15;114:1203-1215. (PMID: 29634965); Am J Clin Dermatol. 2020 Apr;21(2):255-264. (PMID: 31848923); Carbohydr Polym. 2015 Oct 20;131:407-14. (PMID: 26256201); Chem Eng J. 2018 May 15;340:9-14. (PMID: 31384170); Int J Low Extrem Wounds. 2022 Dec;21(4):450-456. (PMID: 32856522); Prog Biomater. 2020 Jun;9(1-2):45-64. (PMID: 32474882); Biomacromolecules. 2020 May 11;21(5):1802-1811. (PMID: 31967794); Diabetes Ther. 2019 Feb;10(1):95-105. (PMID: 30465160); J Diabetes Complications. 2020 Oct;34(10):107638. (PMID: 32527671); Biomed Pharmacother. 2019 Apr;112:108615. (PMID: 30784919); J Wound Care. 2017 Nov 2;26(11):652-660. (PMID: 29131746); Biomacromolecules. 2021 Jul 12;22(7):3049-3059. (PMID: 34128646); Carbohydr Polym. 2019 Dec 15;226:115302. (PMID: 31582049); Int J Nanomedicine. 2020 Nov 23;15:9265-9282. (PMID: 33262587); Des Monomers Polym. 2020 Aug 5;23(1):118-133. (PMID: 33029080); Turk J Pharm Sci. 2019 Sep;16(3):252-260. (PMID: 32454722); Biomaterials. 2020 Aug;249:120020. (PMID: 32305816); Pharmaceutics. 2018 Apr 02;10(2):. (PMID: 29614804); Wound Repair Regen. 2017 Aug;25(4):591-608. (PMID: 28783878); Int J Biol Macromol. 2022 Mar 31;202:657-670. (PMID: 35066024); Drug Deliv. 2020 Dec;27(1):632-641. (PMID: 32329376); Int J Mol Med. 2013 Feb;31(2):471-6. (PMID: 23254439); RSC Adv. 2018 Feb 16;8(14):7533-7549. (PMID: 35539132); Int Wound J. 2015 Dec;12(6):620-4. (PMID: 24974913); Polymers (Basel). 2021 Nov 26;13(23):. (PMID: 34883634); BMC Surg. 2021 Feb 15;21(1):87. (PMID: 33588807); Biomater Adv. 2022 Mar;134:112560. (PMID: 35523648); Colloids Surf B Biointerfaces. 2022 Jun;214:112480. (PMID: 35358884); Trends Biotechnol. 2018 Oct;36(10):1040-1053. (PMID: 29914650); Plants (Basel). 2022 Sep 14;11(18):. (PMID: 36145799); J Wound Care. 2017 May 1;26(Sup5):S1-S43. (PMID: 28475468); Wound Repair Regen. 2020 May;28(3):326-337. (PMID: 31868976); ACS Omega. 2022 Sep 14;7(38):33793-33807. (PMID: 36188287); Sci Adv. 2021 Aug 27;7(35):. (PMID: 34452918); Pharmaceutics. 2021 Jul 03;13(7):. (PMID: 34371712); Nanomaterials (Basel). 2021 Sep 13;11(9):. (PMID: 34578695); Biomolecules. 2021 Jun 22;11(7):. (PMID: 34206433); J Dtsch Dermatol Ges. 2014 Jul;12(7):541-54. (PMID: 24813380); Placenta. 2016 Dec;48:99-103. (PMID: 27871479); J Appl Microbiol. 2019 Dec;127(6):1612-1626. (PMID: 31021482); Microsyst Nanoeng. 2020 May 18;6:46. (PMID: 34567658); J Biomed Mater Res B Appl Biomater. 2020 Apr;108(3):892-909. (PMID: 31339655); Sci Rep. 2021 Feb 9;11(1):3428. (PMID: 33564036); Front Pharmacol. 2020 Feb 28;11:155. (PMID: 32180720); Polymers (Basel). 2021 Dec 09;13(24):. (PMID: 34960852); Adv Wound Care (New Rochelle). 2023 Apr;12(4):177-186. (PMID: 35593010); Int J Nanomedicine. 2018 Jul 04;13:3897-3906. (PMID: 30013343); Mar Drugs. 2020 Dec 21;18(12):. (PMID: 33371380); Int J Biol Macromol. 2020 Nov 1;162:1414-1428. (PMID: 32777428); Nanomaterials (Basel). 2020 Feb 23;10(2):. (PMID: 32102229); ACS Omega. 2020 Jul 08;5(28):17152-17159. (PMID: 32715200); Biomed Pharmacother. 2022 Nov;155:113708. (PMID: 36162373); Sci Rep. 2020 Apr 30;10(1):7342. (PMID: 32355267); Pharmaceuticals (Basel). 2020 Apr 01;13(4):. (PMID: 32244718); Polymers (Basel). 2022 Feb 14;14(4):. (PMID: 35215637); Nat Rev Mater. 2020 Jul;5(7):539-551. (PMID: 32953138); Materials (Basel). 2021 Mar 25;14(7):. (PMID: 33806228); Acta Biomater. 2020 Feb;103:142-152. (PMID: 31846801); J Orthop Translat. 2021 Aug 12;30:6-15. (PMID: 34466384); J Biomater Sci Polym Ed. 2018 Jul;29(10):1185-1206. (PMID: 29490569); Polymers (Basel). 2020 Apr 06;12(4):. (PMID: 32268612); Int J Biol Macromol. 2018 Oct 15;118(Pt B):1892-1902. (PMID: 30017987) |
| Contributed Indexing: | Keywords: Matrigel; alginate-hydrogel-based dressing; oxygen-enriched polylactic acid microspheres; skin; wound healing |
| Entry Date(s): | Date Created: 20230329 Latest Revision: 20230331 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10057140 |
| DOI: | 10.3390/pharmaceutics15030857 |
| PMID: | 36986719 |
| Database: | MEDLINE |
Journal Article