CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.
| Title: | CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples. |
|---|---|
| Authors: | Fredi BM; Marilia Medical School (FAMEMA), Marilia, São Paulo, Brazil. bruno.fredi@famema.br.; De Labio RW; Marilia Medical School (FAMEMA), Marilia, São Paulo, Brazil.; Rasmussen LT; Marilia Medical School (FAMEMA), Marilia, São Paulo, Brazil.; Chagas EFB; Marilia Medical School (FAMEMA), Marilia, São Paulo, Brazil.; University of Marilia, Marilia, São Paulo, Brazil.; Chen ES; Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, São Paulo, Brazil.; Turecki G; The Douglas-Bell Canada Brain Bank, Douglas Mental Health University, Montreal, QC, Canada.; Smith MAC; Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, São Paulo, Brazil.; Payão SLM; Marilia Medical School (FAMEMA), Marilia, São Paulo, Brazil. |
| Source: | Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Aug; Vol. 43 (6), pp. 2953-2962. Date of Electronic Publication: 2023 Mar 29. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: Netherlands NLM ID: 8200709 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1981- : [Dordrecht, Netherlands] : Springer; Original Publication: New York : Plenum Press, c1981- |
| MeSH Terms: | Alzheimer Disease*/metabolism; Amyloid beta-Peptides/metabolism ; Neurofibrillary Tangles/metabolism ; Brain/metabolism ; Forkhead Box Protein O1/genetics ; Forkhead Box Protein O1/metabolism ; Forkhead Box Protein O3/genetics ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Humans ; Aged ; Gene Expression |
| Abstract: | Alzheimer's disease (AD) is a progressive neuroinflammatory and neurodegenerative disorder that affects different regions of the brain. Its pathophysiology includes the accumulation of β-amyloid protein, formation of neurofibrillary tangles, and inflammatory processes. Genetic factors are involved in the onset of AD, but they are not fully elucidated. Identification of gene expression in encephalic tissues of patients with AD may help elucidate its development. Our objectives were to characterize and compare the gene expression of CDK10, CDK11, FOXO1, and FOXO3 in encephalic tissue samples from AD patients and elderly controls, from the auditory cortex and cerebellum. RT-qPCR was used on samples from 82 individuals (45 with AD and 37 controls). We observed a statistically significant increase in CDK10 (p = 0.029*) and CDK11 (p = 0.048*) gene expression in the AD group compared to the control, which was most evident in the cerebellum. Furthermore, the Spearman test demonstrated the presence of a positive correlation of gene expression both in the auditory cortex in the AD group (r = 0.046/p = 0.004) and control group (r = 0.454/p = 0.005); and in the cerebellum in the AD group (r = 0.654 /p |
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| Grant Information: | 88887.609695/2021-00 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| Contributed Indexing: | Keywords: Alzheimer-disease; CDKs; Dementia; FOXOs; Gene-expression |
| Substance Nomenclature: | 0 (Amyloid beta-Peptides); 0 (FOXO1 protein, human); 0 (Forkhead Box Protein O1); 0 (FOXO3 protein, human); 0 (Forkhead Box Protein O3); EC 2.7.11.22 (CDK10 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinases) |
| Entry Date(s): | Date Created: 20230329 Date Completed: 20230712 Latest Revision: 20250306 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11410123 |
| DOI: | 10.1007/s10571-023-01341-9 |
| PMID: | 36988771 |
| Database: | MEDLINE |
Journal Article