Factors related to intracerebral haematoma in patients with aneurysmal subarachnoid haemorrhage in Vietnam: a multicentre prospective cohort study.
| Title: | Factors related to intracerebral haematoma in patients with aneurysmal subarachnoid haemorrhage in Vietnam: a multicentre prospective cohort study. |
|---|---|
| Authors: | Nguyen TA; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Mai TD; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam.; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam.; Vu LD; Department of Radiology, Hanoi Medical University, Hanoi, Viet Nam.; Radiology Centre, Bach Mai Hospital, Hanoi, Viet Nam.; Dao CX; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam.; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Ngo HM; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam.; Department of Neurosurgery II, Neurosurgery Center, Vietnam-Germany Friendship Hospital, Hanoi, Viet Nam.; Department of Surgery, Hanoi Medical University, Hanoi, Viet Nam.; Hoang HB; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Emergency and Critical Care Department, Hanoi Medical University Hospital, Hanoi Medical University, Hanoi, Viet Nam.; Tran TA; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam.; Department of Radiology, Hanoi Medical University, Hanoi, Viet Nam.; Radiology Centre, Bach Mai Hospital, Hanoi, Viet Nam.; Pham TQ; Department of Surgery, Hanoi Medical University, Hanoi, Viet Nam.; Department of Neurosurgery, Bach Mai Hospital, Hanoi, Viet Nam.; Pham DT; Department of Nutrition and Food Safety, Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.; Nguyen MH; Department of Health Organization and Management, Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.; Nguyen LQ; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Dao PV; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam.; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam.; Nguyen DN; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Vuong HTT; Department of Emergency, Vietnam-Czechoslovakia Friendship Hospital, Hai Phong, Viet Nam.; Vu HD; Emergency and Critical Care Department, Hanoi Medical University Hospital, Hanoi Medical University, Hanoi, Viet Nam.; Nguyen DD; Department of Neurosurgery II, Neurosurgery Center, Vietnam-Germany Friendship Hospital, Hanoi, Viet Nam.; Vu TD; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Department of Emergency, Agriculture General Hospital, Hanoi, Viet Nam.; Nguyen DT; Stroke Center, Bach Mai Hospital, Hanoi, Viet Nam.; Do ALN; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Pham QT; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Khuat NH; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Department of Intensive Care and Poison Control, Duc Giang General Hospital, Hanoi, Viet Nam.; Duong NV; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Department of Intensive Care and Poison Control, Dien Bien Provincial General Hospital, Dien Bien Phu, Viet Nam.; Ngo CC; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Department of Emergency, Military Central Hospital 108, Hanoi, Viet Nam.; Do SN; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam.; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Nguyen HT; Department of Surgery, Hanoi Medical University, Hanoi, Viet Nam.; Department of Neurosurgery, Bach Mai Hospital, Hanoi, Viet Nam.; Nguyen CV; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Nguyen AD; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Viet Nam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Luong CQ; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Viet Nam luongquocchinh@gmail.com.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam.; Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam. |
| Source: | BMJ open [BMJ Open] 2023 Apr 21; Vol. 13 (4), pp. e066186. Date of Electronic Publication: 2023 Apr 21. |
| Publication Type: | Multicenter Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BMJ Publishing Group Ltd, 2011- |
| MeSH Terms: | Subarachnoid Hemorrhage*/complications ; Subarachnoid Hemorrhage*/diagnostic imaging ; Intracranial Aneurysm*/complications ; Intracranial Aneurysm*/diagnostic imaging ; Intracranial Aneurysm*/surgery ; Stroke*/complications; Vietnam/epidemiology ; Cerebral Hemorrhage/complications ; Hematoma/diagnostic imaging ; Hematoma/epidemiology ; Hematoma/etiology ; Female ; Humans ; Middle Aged ; Male ; Prospective Studies ; Treatment Outcome |
| Abstract: | Objectives: To investigate the impact of intracerebral haematoma (ICH) on the outcomes and the factors related to an ICH in patients with aneurysmal subarachnoid haemorrhage (aSAH) in a low- and middle-income country.; Design: A multicentre prospective cohort study.; Setting: Three central hospitals in Hanoi, Vietnam.; Participants: This study included all patients (≥18 years) presenting with aSAH to the three central hospitals within 4 days of ictus, from August 2019 to June 2021, and excluded patients for whom the admission Glasgow Coma Scale was unable to be scored or patients who became lost at 90 days of follow-up during the study.; Outcome Measures: The primary outcome was ICH after aneurysm rupture, defined as ICH detected on an admission head CT scan. The secondary outcomes were 90-day poor outcomes and 90-day death.; Results: Of 415 patients, 217 (52.3%) were females, and the median age was 57.0 years (IQR: 48.0-67.0). ICH was present in 20.5% (85/415) of patients with aSAH. There was a significant difference in the 90-day poor outcomes (43.5% (37/85) and 29.1% (96/330); p=0.011) and 90-day mortality (36.5% (31/85) and 20.0% (66/330); p=0.001) between patients who had ICH and patients who did not have ICH. The multivariable regression analysis showed that systolic blood pressure (SBP) ≥140 mm Hg (adjusted odds ratio (AOR): 2.674; 95% CI: 1.372 to 5.214; p=0.004), World Federation of Neurosurgical Societies (WFNS) grades II (AOR: 3.683; 95% CI: 1.250 to 10.858; p=0.018) to V (AOR: 6.912; 95% CI: 2.553 to 18.709; p |
| Competing Interests: | Competing interests: None declared. |
| References: | J Neurol Neurosurg Psychiatry. 1962 Nov;25:378-86. (PMID: 14023947); J Neurosurg. 1996 Jan;84(1):43-8. (PMID: 8613834); Lancet. 2022 Sep 10;400(10355):846-862. (PMID: 35985353); J Neurol. 2011 May;258(5):862-5. (PMID: 21153834); Circulation. 2018 May 15;137(20):2166-2178. (PMID: 29760227); Neurosurg Rev. 2014 Oct;37(4):653-9. (PMID: 25011406); J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1365-72. (PMID: 17470467); Br J Neurosurg. 1994;8(3):333-9. (PMID: 7946023); J Neurosurg. 1988 Jun;68(6):985-6. (PMID: 3131498); J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):71-8. (PMID: 24715224); PLoS One. 2015 Oct 29;10(10):e0141731. (PMID: 26513729); Stroke. 2019 Oct;50(10):2952-2955. (PMID: 31370767); Stroke. 1998 Jan;29(1):251-6. (PMID: 9445359); Lancet. 2003 Jul 12;362(9378):103-10. (PMID: 12867109); J Neurosurg. 1968 Jan;28(1):14-20. (PMID: 5635959); J Clin Neurosci. 2022 Jan;95:70-74. (PMID: 34929654); Eur Heart J. 2000 Jul;21(14):1141-51. (PMID: 10924297); Stroke. 2012 Jun;43(6):1711-37. (PMID: 22556195); Stroke. 2022 Feb;53(2):624-633. (PMID: 34983239); J Neurol Neurosurg Psychiatry. 2013 Jun;84(6):619-23. (PMID: 23355806); Stroke. 2005 Dec;36(12):2773-80. (PMID: 16282541); J Neurosurg. 2016 Dec;125(6):1344-1351. (PMID: 26918469); J Neurosurg. 1997 Aug;87(2):170-5. (PMID: 9254078); Neurosurgery. 2008 Dec;63(6):1088-93; discussion 1093-4. (PMID: 19057320); J Stroke Cerebrovasc Dis. 2018 Mar;27(3):660-668. (PMID: 29122467); Neurochirurgie. 2019 Feb;65(1):14-19. (PMID: 30638547); Neurol Med Chir (Tokyo). 2010;50(10):884-92. (PMID: 21030799); Cerebrovasc Dis Extra. 2019;9(2):77-89. (PMID: 31408859); Neurocrit Care. 2011 Jun;14(3):407-15. (PMID: 21174171); PLoS One. 2021 Aug 13;16(8):e0256150. (PMID: 34388213); Stroke. 1988 May;19(5):604-7. (PMID: 3363593); Br J Neurosurg. 1999 Feb;13(1):18-24. (PMID: 10492680); Stroke. 1991 Jul;22(7):848-53. (PMID: 1853404); Neurocrit Care. 2019 Jun;30(Suppl 1):4-19. (PMID: 31087257); Neurosurgery. 2016 Jun;78(6):813-20. (PMID: 26619334); Surg Neurol. 1995 Mar;43(3):272-7. (PMID: 7792692); Stroke. 2010 Nov;41(11):2592-5. (PMID: 20947853); Environ Health Prev Med. 2017 Oct 30;22(1):74. (PMID: 29165160); Neurosurg Focus. 2003 Oct 15;15(4):E4. (PMID: 15344897); Bull World Health Organ. 2021 Jan 01;99(1):50-61. (PMID: 33658734); J Neurosurg. 2003 Nov;99(5):843-7. (PMID: 14609163); Neurol Med Chir (Tokyo). 1998 Dec;38(12):844-8; discussion 849-50. (PMID: 10063358); J Am Heart Assoc. 2015 May 27;4(6):e001553. (PMID: 26019130); Int J Stroke. 2007 Nov;2(4):279-80. (PMID: 18705929) |
| Contributed Indexing: | Keywords: accident & emergency medicine; adult intensive & critical care; neurosurgery; stroke; stroke medicine |
| Entry Date(s): | Date Created: 20230421 Date Completed: 20230425 Latest Revision: 20230426 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10124281 |
| DOI: | 10.1136/bmjopen-2022-066186 |
| PMID: | 37085308 |
| Database: | MEDLINE |
Multicenter Study; Journal Article