Neoadjuvant Chemoradiation for Rectal Cancer Achieves Satisfactory Tumour Regression and Local Recurrence - Result of a Dedicated Multi-disciplinary Approach from a South Asian Centre.
| Title: | Neoadjuvant Chemoradiation for Rectal Cancer Achieves Satisfactory Tumour Regression and Local Recurrence - Result of a Dedicated Multi-disciplinary Approach from a South Asian Centre. |
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| Authors: | Deen R; Department of Surgery, Wollongong Hospital, Wollongong, NSW, Australia. raeeddeen30@gmail.com.; Ediriweera DS; Health Data Science Unit, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.; Thillakaratne S; Department of Surgery, University of Kelaniya, Kelaniya, Sri Lanka.; Hewavissenthi J; Department of Pathology, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.; Kumarage SK; Department of Surgery, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.; Chandrasinghe PC; Department of Surgery, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.; The Department of Surgery, University of Kelaniya and North Colombo Teaching Hospital, Ragama, Sri Lanka. |
| Source: | BMC cancer [BMC Cancer] 2023 May 04; Vol. 23 (1), pp. 400. Date of Electronic Publication: 2023 May 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| MeSH Terms: | Rectal Neoplasms*/radiotherapy ; Rectal Neoplasms*/drug therapy ; Proctectomy*; Lymph Nodes/pathology ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Recurrence, Local/pathology ; Humans ; Male ; Female ; Middle Aged ; Neoadjuvant Therapy ; Chemoradiotherapy ; Neoplasm Staging ; Treatment Outcome |
| Abstract: | Background: Pre-operative long-course chemoradiotherapy (CRT) for rectal cancer has resulted in improvement in rates of restorative rectal resection and local recurrence by inducing tumour downstaging and downsizing. Total mesorectal excision (TME) is a standardised surgical technique of low anterior resection aimed at the prevention of local tumour recurrence. The purpose of this study was to evaluate tumour response following CRT in a standardised group of patients with rectal cancer.; Methods: One hundred and thirty-one patients (79 male; 52 female, median age 57; interquartile range 47-62 years) of 153 with rectal cancer who underwent pre-operative long-course CRT were treated by standardised open low anterior resection at a median of 10 weeks post-CRT. Sixteen of 131 (12%) were 70 years or older. Median follow-up at the time of analysis was 15 months (interquartile range 6-45 months). Pathology reports were analysed based on AJCC-UICC classification using the TNM system. Data recorded were overall/subgrades of tumour regression; good, moderate or poor, lymph node harvest, local recurrence, disease-free and overall survival using standard statistical methods.; Results: 78% showed tumour regression post-CRT; 43% displayed good tumour regression/response while 22% had poor tumour regression/response. All patients had a pre-operative T-stage of either T3 or T4. Post-operation, good responders had a median T stage of T2 vs. T3 in poor responders (P = 0.0002). Overall, the median lymph node harvest was |
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| Grant Information: | #00-25 National Research Council Sri Lanka |
| Contributed Indexing: | Keywords: Chemoradiation; Local recurrence; Lymph node harvest; Rectal cancer; Tumour regression |
| Entry Date(s): | Date Created: 20230504 Date Completed: 20230508 Latest Revision: 20230508 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10158249 |
| DOI: | 10.1186/s12885-023-10769-7 |
| PMID: | 37142979 |
| Database: | MEDLINE |
Journal Article