Development and characterization of chimera of yellow fever virus vaccine strain and Tick-Borne encephalitis virus.
| Title: | Development and characterization of chimera of yellow fever virus vaccine strain and Tick-Borne encephalitis virus. |
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| Authors: | Kuznetsova N; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Siniavin A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Molecular Neuroimmune Signalling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Butenko A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Larichev V; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Kozlova A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Usachev E; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Nikiforova M; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Usacheva O; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Shchetinin A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Pochtovyi A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Virology, Lomonosov Moscow State University, Moscow, Russia.; Shidlovskaya E; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Odintsova A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Belyaeva E; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Voskoboinikov A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Bessonova A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Vasilchenko L; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Karganova G; Laboratory of Biology of Arboviruses, FSASI Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of RAS, Moscow, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov University, Moscow, Russia.; Zlobin V; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Logunov D; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Gushchin V; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Virology, Lomonosov Moscow State University, Moscow, Russia.; Gintsburg A; Federal State Budgetary Institution 'National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. |
| Source: | PloS one [PLoS One] 2023 May 10; Vol. 18 (5), pp. e0284823. Date of Electronic Publication: 2023 May 10 (Print Publication: 2023). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Yellow Fever Vaccine*/genetics ; Encephalitis Viruses, Tick-Borne* ; Viral Vaccines* ; Encephalitis, Tick-Borne*; Yellow fever virus/genetics ; Humans ; Animals ; Mice ; Mammals |
| Abstract: | Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 107-106 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.; (Copyright: © 2023 Kuznetsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Substance Nomenclature: | 0 (Yellow Fever Vaccine); 0 (Viral Vaccines) |
| Entry Date(s): | Date Created: 20230510 Date Completed: 20230512 Latest Revision: 20230605 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10171666 |
| DOI: | 10.1371/journal.pone.0284823 |
| PMID: | 37163522 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't