Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.
| Title: | Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts. |
|---|---|
| Authors: | Colbert SMC; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: sarah.colbert@icahn.mssm.edu.; Wendt FR; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; VA Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), VA CT Healthcare System, West Haven, CT, USA; Department of Anthropology, University of Toronto, Mississauga, ON, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Pathak GA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; VA Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), VA CT Healthcare System, West Haven, CT, USA.; Helmer DA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Center for Innovations in Quality, Effectiveness, and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.; Hauser ER; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27705, USA; VA Cooperative Studies Program Epidemiology Center-Durham, Department of Veterans Affairs, Durham, NC 27705, USA.; Keller MC; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Polimanti R; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; VA Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), VA CT Healthcare System, West Haven, CT, USA.; Johnson EC; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA. |
| Source: | American journal of human genetics [Am J Hum Genet] 2023 Jun 01; Vol. 110 (6), pp. 1008-1014. Date of Electronic Publication: 2023 May 12. |
| Publication Type: | Meta-Analysis; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2008- : [Cambridge, MA] : Cell Press; Original Publication: Baltimore, American Society of Human Genetics. |
| MeSH Terms: | Polymorphism, Single Nucleotide* ; Population Health*; Humans ; Homozygote |
| Abstract: | Previous studies have hypothesized that autozygosity is decreasing over generational time. However, these studies were limited to relatively small samples (n |
| Competing Interests: | Declaration of interests R.P. is paid for their editorial work on the journal Complex Psychiatry and reports a research grant from Alkermes. |
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| Grant Information: | OT2 OD026556 United States OD NIH HHS; R21 DC018098 United States DC NIDCD NIH HHS; OT2 OD025315 United States OD NIH HHS; OT2 OD026551 United States OD NIH HHS; U24 OD023121 United States OD NIH HHS; OT2 OD026552 United States OD NIH HHS; OT2 OD026549 United States OD NIH HHS; OT2 OD025337 United States OD NIH HHS; K01 DA051759 United States DA NIDA NIH HHS; OT2 OD025277 United States OD NIH HHS; OT2 OD026555 United States OD NIH HHS; OT2 OD026550 United States OD NIH HHS; T32 MH014276 United States MH NIMH NIH HHS; OT2 OD026553 United States OD NIH HHS; OT2 OD023205 United States OD NIH HHS; OT2 OD025276 United States OD NIH HHS; R33 DA047527 United States DA NIDA NIH HHS; OT2 OD026554 United States OD NIH HHS; U24 OD023163 United States OD NIH HHS; OT2 OD023206 United States OD NIH HHS; U24 OD023176 United States OD NIH HHS; OT2 OD026548 United States OD NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS; U2C OD023196 United States OD NIH HHS; R01 MH100141 United States MH NIMH NIH HHS; OT2 OD026557 United States OD NIH HHS |
| Contributed Indexing: | Keywords: F(ROH); autozygosity; panmixia; runs of homozygosity |
| Entry Date(s): | Date Created: 20230513 Date Completed: 20230605 Latest Revision: 20240921 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10257001 |
| DOI: | 10.1016/j.ajhg.2023.04.007 |
| PMID: | 37178685 |
| Database: | MEDLINE |
Meta-Analysis; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't