Effects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters.
| Title: | Effects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters. |
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| Authors: | Yoder KK; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA. kkyoder@iupui.edu.; Center for Neuroimaging, Indiana Institute of Biomedical Imaging, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA. kkyoder@iupui.edu.; Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, Ste. 414, Indianapolis, IN, 46202, USA. kkyoder@iupui.edu.; Chumin EJ; Center for Neuroimaging, Indiana Institute of Biomedical Imaging, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, Ste. 414, Indianapolis, IN, 46202, USA.; Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th St, IN, 47405, Bloomington, USA.; Indiana University Network Science Institute, Indiana University, 1015 E 11th St, Bloomington, IN, 47408, USA.; Mustafi SM; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Center for Neuroimaging, Indiana Institute of Biomedical Imaging, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Kolleck KA; Indiana University School of Medicine, 340 W. 10th St., Indianapolis, IN, 46202, USA.; Halcomb ME; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Center for Neuroimaging, Indiana Institute of Biomedical Imaging, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Hile KL; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Center for Neuroimaging, Indiana Institute of Biomedical Imaging, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Plawecki MH; Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4800, Indianapolis, IN, 46202, USA.; O'Connor SJ; Department of Psychiatry, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4800, Indianapolis, IN, 46202, USA.; Dzemidzic M; Department of Neurology, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4700, Indianapolis, IN, 46202, USA.; Wu YC; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Center for Neuroimaging, Indiana Institute of Biomedical Imaging, Indiana University School of Medicine, 355 W. 16th St., GH Ste. 4100, Indianapolis, IN, 46202, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, Ste. 414, Indianapolis, IN, 46202, USA. |
| Source: | Psychopharmacology [Psychopharmacology (Berl)] 2023 Jul; Vol. 240 (7), pp. 1465-1472. Date of Electronic Publication: 2023 May 20. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer-Verlag. |
| MeSH Terms: | Alcoholism*/diagnostic imaging ; White Matter*; Brain/physiology ; Diffusion Tensor Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Neurites ; Alcohol Drinking |
| Abstract: | Rationale: Little is known about how acute and chronic alcohol exposure may alter the in vivo membrane properties of neurons.; Objectives: We employed neurite orientation dispersion and density imaging (NODDI) to examine acute and chronic effects of alcohol exposure on neurite density.; Methods: Twenty-one healthy social drinkers (CON) and thirteen nontreatment-seeking individuals with alcohol use disorder (AUD) underwent a baseline multi-shell diffusion magnetic resonance imaging (dMRI) scan. A subset (10 CON, 5 AUD) received dMRI during intravenous infusions of saline and alcohol during dMRI. NODDI parametric images included orientation dispersion (OD), isotropic volume fraction (ISOVF), and corrected intracellular volume fraction (cICVF). Diffusion tensor imaging metrics of fractional anisotropy and mean, axial, and radial diffusivity (FA, MD, AD, RD) were also computed. Average parameter values were extracted from white matter (WM) tracts defined by the Johns Hopkins University atlas.; Results: There were group differences in FA, RD, MD, OD, and cICVF, primarily in the corpus callosum. Both saline and alcohol had effects on AD and cICVF in WM tracts proximal to the striatum, cingulate, and thalamus. This is the first work to indicate that acute fluid infusions may alter WM properties, which are conventionally believed to be insensitive to acute pharmacological challenges. It also suggests that the NODDI approach may be sensitive to transient changes in WM. The next steps should include determining if the effect on neurite density differs with solute or osmolality, or both, and translational studies to assess how alcohol and osmolality affect the efficiency of neurotransmission.; (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| Grant Information: | R01 AA026014 United States AA NIAAA NIH HHS; UL1 TR001108 United States TR NCATS NIH HHS; T32 AA07462 United States AA NIAAA NIH HHS; P60 AA007611 United States AA NIAAA NIH HHS; P50 AA007611 United States AA NIAAA NIH HHS; F31 AA025518 United States AA NIAAA NIH HHS; R01 AA018354 United States AA NIAAA NIH HHS; F31AA025518 United States AA NIAAA NIH HHS; R01 AG053993 United States AG NIA NIH HHS; R01 NS112303 United States NS NINDS NIH HHS; R21 AA016901 United States AA NIAAA NIH HHS; UL1TR001108 United States NH NIH HHS; R21AA016901 United States AA NIAAA NIH HHS; T32 AA007462 United States AA NIAAA NIH HHS; R01AG053993 United States AG NIA NIH HHS; R01AA018354 United States AA NIAAA NIH HHS |
| Contributed Indexing: | Keywords: Acute alcohol intoxication; Alcohol; Alcohol use disorder; Axonal density; Diffusion-weighted imaging; HYDI; NODDI; Neurite; Osmolality; White matter |
| Entry Date(s): | Date Created: 20230520 Date Completed: 20230619 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10594986 |
| DOI: | 10.1007/s00213-023-06380-0 |
| PMID: | 37209164 |
| Database: | MEDLINE |
Journal Article