Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam.
| Title: | Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam. |
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| Authors: | Gerth-Guyette E; Diagnostics Program, PATH, Seattle, WA 98121, USA.; Nguyen HT; Vietnam Program, PATH, Hanoi 10080, Vietnam.; Nowak S; Diagnostics Program, PATH, Seattle, WA 98121, USA.; Hoang NT; Vietnam Program, PATH, Hanoi 10080, Vietnam.; Mai ĐTT; National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi 10000, Vietnam.; Thị Sang V; National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi 10000, Vietnam.; Long NĐ; National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi 10000, Vietnam.; Mvundura M; Diagnostics Program, PATH, Seattle, WA 98121, USA.; Nguyen N; Vietnam Program, PATH, Hanoi 10080, Vietnam.; Domingo GJ; Diagnostics Program, PATH, Seattle, WA 98121, USA.; Phúc BQ; National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi 10000, Vietnam. |
| Source: | Pathogens (Basel, Switzerland) [Pathogens] 2023 May 08; Vol. 12 (5). Date of Electronic Publication: 2023 May 08. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
| Abstract: | Plasmodium vivax cases represent more than 50% of a diminishing malaria case load in Vietnam. Safe and effective radical cure strategies could support malaria elimination by 2030. This study investigated the operational feasibility of introducing point-of-care quantitative glucose-6-phosphate dehydrogenase (G6PD) testing into malaria case management practices. A prospective interventional study was conducted at nine district hospitals and commune health stations in Binh Phuoc and Gia Lai provinces in Vietnam over the period of October 2020 to October 2021. The STANDARD™ G6PD Test (SD Biosensor, Seoul, Republic of Korea) was incorporated to inform P. vivax case management. Case management data and patient and health care provider (HCP) perspectives, as well as detailed cost data were collected. The G6PD test results were interpreted correctly by HCP and the treatment algorithm was adhered to for the majority of patients. One HCP consistently ran the test incorrectly, which was identified during the monitoring and resulted in provision of refresher training and updating of training materials and patient retesting. There was wide acceptability of the intervention among patients and HCP albeit with opportunities to improve the counseling materials. Increasing the number of facilities to which the test was deployed and decreases in the malaria cases resulted in higher per patient cost for incorporating G6PD testing into the system. Commodity costs can be reduced by using the 10-unit kits compared to the 25 unit kits, particularly when the case loads are low. These results demonstrate intervention feasibility while also highlighting specific challenges for a country approaching malaria elimination. |
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| Grant Information: | OPP1107113, OPP1054404 and OPP1164105 Foreign, Commonwealth & Development Office, United Kingdom and the Bill & Melinda Gates Foundation |
| Contributed Indexing: | Keywords: G6PD deficiency; diagnostics; hemolytic anemia; primaquine; tafenoquine; vivax malaria |
| Entry Date(s): | Date Created: 20230527 Latest Revision: 20230529 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10222310 |
| DOI: | 10.3390/pathogens12050689 |
| PMID: | 37242359 |
| Database: | MEDLINE |
Journal Article