Factors Associated With Cognitive Improvement After Bariatric Surgery Among Patients With Severe Obesity in the Netherlands.
| Title: | Factors Associated With Cognitive Improvement After Bariatric Surgery Among Patients With Severe Obesity in the Netherlands. |
|---|---|
| Authors: | Vreeken D; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.; Department of Bariatric Surgery, Vitalys, Rijnstate Hospital, Arnhem, the Netherlands.; Seidel F; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research, Leiden, the Netherlands.; Custers EM; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.; Department of Bariatric Surgery, Vitalys, Rijnstate Hospital, Arnhem, the Netherlands.; Olsthoorn L; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.; Cools S; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.; Aarts EO; Department of Surgery, WeightWorks Clinics, Amersfoort, the Netherlands.; Kleemann R; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research, Leiden, the Netherlands.; Kessels RPC; Department of Medical Psychology and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.; Department of Neuropsychology and Rehabilitation Psychology, Centre for Cognition, Radboud University, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.; Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands.; Wiesmann M; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands.; Hazebroek EJ; Department of Bariatric Surgery, Vitalys, Rijnstate Hospital, Arnhem, the Netherlands.; Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.; Kiliaan AJ; Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands. |
| Source: | JAMA network open [JAMA Netw Open] 2023 May 01; Vol. 6 (5), pp. e2315936. Date of Electronic Publication: 2023 May 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Chicago, IL : American Medical Association, [2018]- |
| MeSH Terms: | Obesity, Morbid*/complications ; Obesity, Morbid*/surgery ; Bariatric Surgery*; Netherlands/epidemiology ; Obesity/complications ; Humans ; Female ; Adult ; Middle Aged ; Leptin ; Cohort Studies ; Adiponectin ; C-Reactive Protein ; Adipokines |
| Abstract: | Importance: Bariatric surgery-induced weight loss is often associated with improved cognitive function. However, improvement in cognitive function is not always exhibited by all patients, and the mechanisms behind cognitive improvement remain unknown.; Objective: To investigate the association of changes in adipokines, inflammatory factors, mood, and physical activity with alterations in cognitive function after bariatric surgery among patients with severe obesity.; Design, Setting, and Participants: This cohort study included 156 patients with severe obesity (body mass index [calculated as weight in kilograms divided by height in meters squared], >35) eligible for Roux-en-Y gastric bypass, aged between 35 and 55 years, who were enrolled in the BARICO (Bariatric Surgery Rijnstate and Radboudumc Neuroimaging and Cognition in Obesity) study between September 1, 2018, and December 31, 2020. Follow-up was completed July 31, 2021; 146 participants completed the 6-month follow-up and were included in the analysis.; Intervention: Roux-en-Y gastric bypass.; Main Outcomes and Measures: Overall cognitive performance (based on a 20% change index of the compound z score), inflammatory factors (eg, C-reactive protein and interleukin 6 levels), adipokines (eg, leptin and adiponectin levels), mood (assessed via the Beck Depression Inventory), and physical activity (assessed with the Baecke questionnaire).; Results: A total of 146 patients (mean [SD] age, 46.1 [5.7] years; 124 women [84.9%]) completed the 6-month follow-up and were included. After bariatric surgery, all plasma levels of inflammatory markers, including C-reactive protein (median change, -0.32 mg/dL [IQR, -0.57 to -0.16 mg/dL]; P |
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| Substance Nomenclature: | 0 (Leptin); 0 (Adiponectin); 9007-41-4 (C-Reactive Protein); 0 (Adipokines) |
| Entry Date(s): | Date Created: 20230530 Date Completed: 20230601 Latest Revision: 20230609 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10230316 |
| DOI: | 10.1001/jamanetworkopen.2023.15936 |
| PMID: | 37252738 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't