Extrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19.
| Title: | Extrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19. |
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| Authors: | Allard-Chamard H; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Rheumatology, Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke et Centre de Recherche Clinique Étienne-Le Bel, Sherbrooke, QC J1K 2R1, Canada.; Kaneko N; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.; Bertocchi A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Sun N; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Boucau J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Kuo HH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Farmer JR; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Perugino C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Rheumatology Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.; Mahajan VS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Murphy SJH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Premo K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Diefenbach T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Ghebremichael M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Yuen G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Kotta A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Akman Z; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Biology and Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Moriyama M; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.; Maehara T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.; Nakamura S; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.; Stone JH; Division of Rheumatology Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.; Padera RF; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Pillai S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: pillai@helix.mgh.harvard.edu. |
| Source: | Cell reports [Cell Rep] 2023 Jun 27; Vol. 42 (6), pp. 112630. Date of Electronic Publication: 2023 May 30. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| MeSH Terms: | B-Lymphocyte Subsets*/metabolism ; B-Lymphocyte Subsets*/pathology ; COVID-19* ; Immunoglobulin G4-Related Disease*; Humans ; Fibrosis ; Immunoglobulin D ; Inflammation ; Receptors, CXCR5 |
| Abstract: | Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been identified. The circulating immunoglobulin D (IgD)-CD27-CXCR5-CD11c+ DN2 B cell subset has been previously studied in some autoimmune diseases. A distinct IgD-CD27-CXCR5-CD11c- DN3 B cell subset accumulates in the blood both in IgG4-related disease, an autoimmune disease in which inflammation and fibrosis can be reversed by B cell depletion, and in severe COVID-19. These DN3 B cells prominently accumulate in the end organs of IgG4-related disease and in lung lesions in COVID-19, and double-negative B cells prominently cluster with CD4+ T cells in these lesions. Extrafollicular DN3 B cells may participate in tissue inflammation and fibrosis in autoimmune fibrotic diseases, as well as in COVID-19.; (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interests S.P. is on the scientific advisory boards of Abpro, Inc., BeBiopharma, Inc., Paratus Biosciences, and Octagon Therapeutics. |
| Grant Information: | K08 AR079615 United States AR NIAMS NIH HHS; P30 DK043351 United States DK NIDDK NIH HHS; U19 AI110495 United States AI NIAID NIH HHS; United States HHMI Howard Hughes Medical Institute |
| Contributed Indexing: | Keywords: B cell depletion in disease; COVID-19 pathogenesis; CP: Immunology; DN3 B cells; IgG4-related disease; T-B collaboration in disease; double-negative B cells; extrafollicular B cells; inflammatory fibrosis |
| Substance Nomenclature: | 0 (CXCR5 protein, human); 0 (Immunoglobulin D); 0 (Receptors, CXCR5) |
| Entry Date(s): | Date Created: 20230610 Date Completed: 20231012 Latest Revision: 20240923 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10227203 |
| DOI: | 10.1016/j.celrep.2023.112630 |
| PMID: | 37300833 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't