The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture.
| Title: | The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. |
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| Authors: | Poacher AT; Trauma Department, University Hospital of Wales, Cardiff, UK.; Hoskins HC; Trauma Department, University Hospital of Wales, Cardiff, UK.; Protty MB; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK.; Pettit R; Department of Medical Physics, University Hospital of Wales, Cardiff, UK.; Johansen A; Trauma Department, University Hospital of Wales, Cardiff, UK.; Cardiff University School of Postgraduate Medical and Dental Education, University Hospital of Wales, Cardiff, UK. |
| Source: | Postgraduate medical journal [Postgrad Med J] 2023 Jun 15; Vol. 99 (1172), pp. 582-587. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0234135 Publication Model: Print Cited Medium: Internet ISSN: 1469-0756 (Electronic) Linking ISSN: 00325473 NLM ISO Abbreviation: Postgrad Med J Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : Oxford : Oxford University Press; Original Publication: London, Blackwell. |
| MeSH Terms: | Venous Thromboembolism*/epidemiology ; Venous Thromboembolism*/prevention & control ; Venous Thromboembolism*/drug therapy ; Venous Thrombosis*/drug therapy ; Venous Thrombosis*/prevention & control ; Venous Thrombosis*/etiology ; Hip Fractures*/complications ; Pulmonary Embolism*/complications; Heparin, Low-Molecular-Weight/therapeutic use ; Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Postoperative Complications/epidemiology ; Humans ; Retrospective Studies |
| Abstract: | Purpose of the Study: In 2010, the National Institute for Health and Care Excellence (NICE) recommended the use of anticoagulants rather than aspirin as pharmacological thromboprophylaxis after hip fracture. We examine the impact of implementing this change in guidance on the clinical incidence of deep vein thrombosis (DVT).; Study Design: Demographic, radiographic and clinical data were retrospectively collected for 5039 patients admitted to a single tertiary centre in the UK for hip fracture between 2007 and 2017. We calculated rates of lower-limb DVT and examined the impact of the June 2010 change of departmental policy, from use of aspirin to use of low-molecular-weight heparins (LMWH) in hip fracture patients.; Results: Doppler scans were performed in 400 patients in the 180 days after a hip fracture, and identified 40 ipsilateral and 14 contralateral DVTs (p |
| Contributed Indexing: | Keywords: CLINICAL PHARMACOLOGY; Hip; Orthopaedic & trauma surgery; Thromboembolism; Trauma management |
| Substance Nomenclature: | 0 (Heparin, Low-Molecular-Weight); 0 (Anticoagulants); R16CO5Y76E (Aspirin) |
| Entry Date(s): | Date Created: 20230615 Date Completed: 20230619 Latest Revision: 20230821 |
| Update Code: | 20260130 |
| DOI: | 10.1136/postgradmedj-2022-141628 |
| PMID: | 37319149 |
| Database: | MEDLINE |
Journal Article