Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study.
| Title: | Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study. |
|---|---|
| Authors: | Caffé B; Department of Anthropology, Washington State University, Pullman, Washington, USA.; Blackwell A; Department of Anthropology, Washington State University, Pullman, Washington, USA.; Fehrenkamp BD; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.; Washington, Wyoming, Alaska, Montana, Idaho (WWAMI) Medical Education Program, University of Idaho, Moscow, Idaho, USA.; Williams JE; Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.; Pace RM; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.; Lackey KA; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.; Ruiz L; Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Villaviciosa, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Microhealth Group, Oviedo, Spain.; Rodríguez JM; Department of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.; McGuire MA; Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.; Foster JA; Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA.; Sellen DW; Department of Anthropology, University of Toronto, Toronto, Ontario, Canada.; Kamau-Mbuthia EW; Department of Human Nutrition, Egerton University, Nakuru, Kenya.; Kamundia EW; Department of Human Nutrition, Egerton University, Nakuru, Kenya.; Mbugua S; Department of Human Nutrition, Egerton University, Nakuru, Kenya.; Moore SE; Department of Women and Children's Health, King's College London, London, UK.; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia.; Prentice AM; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia.; Kvist LJ; Faculty of Medicine, Lund University, Lund, Sweden.; Otoo GE; Department of Nutrition and Food Science, University of Ghana, Accra, Ghana.; Pareja RG; Nutrition Research Institute, Lima, Peru.; Bode L; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, California, USA.; Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.; Gebeyehu D; Department of Anthropology, Hawassa University, Hawassa, Ethiopia.; Gindola DK; Department of Anthropology, Hawassa University, Hawassa, Ethiopia.; Boothman S; School of Biological Sciences, Washington State University, Pullman, Washington, USA.; Flores K; Department of Anthropology, Washington State University, Pullman, Washington, USA.; McGuire MK; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, USA.; Meehan CL; Department of Anthropology, Washington State University, Pullman, Washington, USA. |
| Source: | American journal of human biology : the official journal of the Human Biology Council [Am J Hum Biol] 2023 Nov; Vol. 35 (11), pp. e23943. Date of Electronic Publication: 2023 Jun 26. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8915029 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6300 (Electronic) Linking ISSN: 10420533 NLM ISO Abbreviation: Am J Hum Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Wiley-Blackwell; Original Publication: New York, NY : Alan R. Liss, Inc., c1989- |
| MeSH Terms: | Milk, Human* ; Nutritional Status*; Lactation/physiology ; Female ; Infant ; Male ; Humans ; Breast Feeding ; Immunologic Factors ; Immunoglobulin G |
| Abstract: | Objectives: Breastfeeding is an energetically costly and intense form of human parental investment, providing sole-source nutrition in early infancy and bioactive components, including immune factors. Given the energetic cost of lactation, milk factors may be subject to tradeoffs, and variation in concentrations have been explored utilizing the Trivers-Willard hypothesis. As human milk immune factors are critical to developing immune system and protect infants against pathogens, we tested whether concentrations of milk immune factors (IgA, IgM, IgG, EGF, TGFβ2, and IL-10) vary in response to infant sex and maternal condition (proxied by maternal diet diversity [DD] and body mass index [BMI]) as posited in the Trivers-Willard hypothesis and consider the application of the hypothesis to milk composition.; Methods: We analyzed concentrations of immune factors in 358 milk samples collected from women residing in 10 international sites using linear mixed-effects models to test for an interaction between maternal condition, including population as a random effect and infant age and maternal age as fixed effects.; Results: IgG concentrations were significantly lower in milk produced by women consuming diets with low diversity with male infants than those with female infants. No other significant associations were identified.; Conclusions: IgG concentrations were related to infant sex and maternal diet diversity, providing minimal support for the hypothesis. Given the lack of associations across other select immune factors, results suggest that the Trivers-Willard hypothesis may not be broadly applied to human milk immune factors as a measure of maternal investment, which are likely buffered against perturbations in maternal condition.; (© 2023 The Authors. American Journal of Human Biology published by Wiley Periodicals LLC.) |
| References: | Evol Med Public Health. 2015 Jan 20;2015(1):21-31. (PMID: 25608691); Breastfeed Med. 2013 Feb;8(1):105-10. (PMID: 22283504); Early Hum Dev. 2015 Nov;91(11):629-35. (PMID: 26375355); Clin Transl Immunology. 2013 Apr 12;2(4):e3. (PMID: 25505951); Front Immunol. 2021 Feb 11;11:614372. (PMID: 33643297); Asia Pac J Public Health. 2016 Jan;28(1):7-14. (PMID: 26792873); Acta Paediatr Scand. 1984 Nov;73(6):796-802. (PMID: 6524367); Evol Med Public Health. 2018 Oct 13;2018(1):230-245. (PMID: 30430010); Am J Clin Nutr. 1983 Apr;37(4):632-40. (PMID: 6837495); Curr Trop Med Rep. 2014 Jun 1;1(2):97-105. (PMID: 24883263); Pediatr Allergy Immunol. 2007 Sep;18(6):495-502. (PMID: 17680907); J Pediatr (Rio J). 2004 Mar-Apr;80(2):123-8. (PMID: 15079182); J Pediatr Gastroenterol Nutr. 2013 May;56(5):560-8. (PMID: 23274339); Proc Biol Sci. 2016 May 11;283(1830):. (PMID: 27170721); J Hum Lact. 2004 May;20(2):153-8; quiz 159-63. (PMID: 15117513); J Pediatr Gastroenterol Nutr. 2015 Jan;60(1):120-6. (PMID: 25207476); Pediatr Allergy Immunol. 2009 Feb;20(1):19-29. (PMID: 18484963); Evol Anthropol. 2011 Jan-Feb;20(1):9-23. (PMID: 22034080); Semin Neonatol. 2002 Aug;7(4):275-81. (PMID: 12401297); PLoS One. 2020 Jan 14;15(1):e0227873. (PMID: 31935272); Vaccine. 2003 Jul 28;21(24):3382-8. (PMID: 12850345); Pediatr Res. 2012 Feb;71(2):220-5. (PMID: 22258136); J Hum Lact. 2011 May;27(2):171-86. (PMID: 21678611); Arch Dis Child. 1983 Jul;58(7):518-22. (PMID: 6683486); Microorganisms. 2021 May 27;9(6):. (PMID: 34072117); Benef Microbes. 2016 Jun;7(3):305-18. (PMID: 26925605); Am J Clin Nutr. 2017 May;105(5):1086-1100. (PMID: 28356278); J Exp Med. 1977 Nov 1;146(5):1311-22. (PMID: 925605); Int J Obes (Lond). 2008 Aug;32 Suppl 3:S56-9. (PMID: 18695655); Am J Hum Biol. 2009 Sep-Oct;21(5):635-42. (PMID: 19378274); Am J Phys Anthropol. 2012 Sep;149(1):52-9. (PMID: 22623326); Eur J Clin Nutr. 2015 Feb;69(2):242-6. (PMID: 25117993); Pediatr Allergy Immunol. 2010 Sep;21(6):977-82. (PMID: 20718928); Pediatr Allergy Immunol. 2008 Sep;19(6):497-504. (PMID: 18221472); Nat Rev Immunol. 2016 Oct;16(10):626-38. (PMID: 27546235); Reprod Biomed Online. 2007 Dec;15 Suppl 2:23-32. (PMID: 18088517); Sci Rep. 2018 Oct 18;8(1):15463. (PMID: 30337613); Acta Paediatr Scand. 1983 May;72(3):461-2. (PMID: 6880736); Food Funct. 2018 Feb 21;9(2):1199-1204. (PMID: 29379938); Nutrients. 2016 Nov 03;8(11):. (PMID: 27827874); Front Nutr. 2019 Apr 17;6:45. (PMID: 31058158); J Nutr. 2016 Oct;146(10):2109-2116. (PMID: 27581578); Front Immunol. 2017 Jun 30;8:696. (PMID: 28713365); Clin Exp Immunol. 2010 Dec;162(3):500-9. (PMID: 20942805); Early Hum Dev. 2004 Apr;77(1-2):67-75. (PMID: 15113633); Am J Phys Anthropol. 2020 Dec;173(4):619-629. (PMID: 32955732); Arch Dis Child. 1998 Mar;78(3):235-9. (PMID: 9613353); Front Pediatr. 2020 Aug 07;8:428. (PMID: 32850542); J Pediatr. 2010 Feb;156(2 Suppl):S31-5. (PMID: 20105663); Trans R Soc Trop Med Hyg. 1985;79(1):90-5. (PMID: 4039482); Acta Paediatr Scand. 1984 Nov;73(6):803-9. (PMID: 6543089); Am J Hum Biol. 2010 Jan-Feb;22(1):50-4. (PMID: 19533619); J Nutr. 2011 Jun;141(6):1181-7. (PMID: 21508211); Public Health Nutr. 2019 Mar;22(4):697-705. (PMID: 30378520); Public Health Nutr. 2005 Oct;8(7A):1010-27. (PMID: 16277817); J Nutr. 2012 Aug;142(8):1603-10. (PMID: 22739373); Pediatr Res. 2010 Oct;68(4):330-4. (PMID: 20581738); Evol Med Public Health. 2019 Nov 11;2019(1):201-211. (PMID: 32405414); Pediatr Clin North Am. 2013 Feb;60(1):49-74. (PMID: 23178060); Front Psychol. 2017 Nov 07;8:1879. (PMID: 29163268); Nutrients. 2021 Feb 12;13(2):. (PMID: 33673254); Nutrients. 2018 Sep 01;10(9):. (PMID: 30200404); Rev Assoc Med Bras (1992). 2016 Sep;62(6):584-593. (PMID: 27849237); Am J Phys Anthropol. 2019 Jul;169(3):526-539. (PMID: 31012086); Science. 1973 Jan 5;179(4068):90-2. (PMID: 4682135); Front Immunol. 2019 Jan 22;10:16. (PMID: 30723472); Am J Phys Anthropol. 2018 Oct;167(2):389-399. (PMID: 30129152); Am J Phys Anthropol. 2013 Oct;152(2):209-16. (PMID: 23996600); Med Sci Sports Exerc. 1997 Dec;29(12):1596-601. (PMID: 9432092); Ann N Y Acad Sci. 1994 Feb 18;709:77-85. (PMID: 8154736); Front Immunol. 2018 Sep 27;9:2222. (PMID: 30319659); Sci Rep. 2022 Jan 25;12(1):1367. (PMID: 35079053); Hum Nat. 2005 Mar;16(1):58-80. (PMID: 26189516); Ann Hum Biol. 2021 Sep;48(6):455-465. (PMID: 35105200); Endocrine. 2002 Feb;17(1):49-53. (PMID: 12014704) |
| Grant Information: | MC_PC_21037 United Kingdom MRC_ Medical Research Council; MC_UU_00026/3 United Kingdom MRC_ Medical Research Council; R01 HD092297 United States HD NICHD NIH HHS; United States NH NIH HHS |
| Substance Nomenclature: | 0 (Immunologic Factors); 0 (Immunoglobulin G) |
| Entry Date(s): | Date Created: 20230626 Date Completed: 20231106 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10749986 |
| DOI: | 10.1002/ajhb.23943 |
| PMID: | 37358306 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.