Usnic Acid-Loaded Magnetite Nanoparticles-A Comparative Study between Synthesis Methods.
| Title: | Usnic Acid-Loaded Magnetite Nanoparticles-A Comparative Study between Synthesis Methods. |
|---|---|
| Authors: | Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Dănciulescu LA; Faculty of Medical Engineering, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Neacșu IA; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Oprea OC; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 011061 Bucharest, Romania.; Trușcă RD; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; Academy of Romanian Scientists, 54 Spl. Independentei, 050045 Bucharest, Romania. |
| Source: | Molecules (Basel, Switzerland) [Molecules] 2023 Jul 04; Vol. 28 (13). Date of Electronic Publication: 2023 Jul 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, c1995- |
| MeSH Terms: | Magnetite Nanoparticles*/chemistry ; Neoplasms*; Humans ; Spectroscopy, Fourier Transform Infrared ; Microscopy, Electron, Scanning ; X-Ray Diffraction ; Benzofurans |
| Abstract: | Since cancer is a continuously increasing concern for the general population, more efficient treatment alternatives ought to be developed. In this regard, a promising direction is represented by the use of magnetite nanoparticles (MNPs) to act both as a nanocarrier for the targeted release of antitumoral drugs and as hyperthermia agents. Thus, the present study focused on improving the control upon the outcome properties of MNPs by using two synthesis methods, namely the co-precipitation and microwave-assisted hydrothermal method, for the incorporation of usnic acid (UA), a natural lichen-derived metabolite with proven anticancer activity. The obtained UA-loaded MNPs were thoroughly characterized regarding their morpho-structural and physicochemical properties through X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and zeta potential, scanning electron microscopy (SEM), and vibrating sample magnetometry (VSM). Results demonstrated the formation of magnetite as the unique mineralogical phase through both types of synthesis, with increased uniformity regarding the drug loading efficiency, size, stability, and magnetic properties obtained through the microwave-assisted hydrothermal method. Furthermore, the cytotoxicity of the nanostructures against the HEK 293T cell line was investigated through the XTT assay, which further proved their potential for anticancer treatment applications. |
| References: | Adv Exp Med Biol. 2019;1214:31-41. (PMID: 30151647); Molecules. 2021 Oct 02;26(19):. (PMID: 34641539); J Nat Prod. 2016 May 27;79(5):1373-80. (PMID: 27186821); J Environ Health Sci Eng. 2016 Nov 25;14:21. (PMID: 27924220); Phytochemistry. 2002 Dec;61(7):729-36. (PMID: 12453567); Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 Jan;116(1):51-4. (PMID: 9080673); Materials (Basel). 2021 Oct 08;14(19):. (PMID: 34640303); Cancers (Basel). 2021 Mar 12;13(6):. (PMID: 33808948); Molecules. 2021 Feb 19;26(4):. (PMID: 33669817); Mar Drugs. 2020 May 20;18(5):. (PMID: 32443816); Pharm Biol. 2010 Mar;48(3):260-3. (PMID: 20645810); Nat Rev Drug Discov. 2021 Feb;20(2):101-124. (PMID: 33277608); J Nanobiotechnology. 2018 Sep 19;16(1):71. (PMID: 30231877); Toxicol In Vitro. 2011 Feb;25(1):37-44. (PMID: 20837130); Nat Prod Commun. 2016 Apr;11(4):493-6. (PMID: 27396202); Front Bioeng Biotechnol. 2020 Jan 31;7:489. (PMID: 32083068); Minerva Ginecol. 1999 Jun;51(6):255-60. (PMID: 10479878); Materials (Basel). 2022 Apr 01;15(7):. (PMID: 35407934); Nanomaterials (Basel). 2018 Nov 24;8(12):. (PMID: 30477241); Ecotoxicol Environ Saf. 2020 Dec 1;205:111345. (PMID: 32961496); Antimicrob Agents Chemother. 2012 Jan;56(1):595-7. (PMID: 22006006); Antimicrob Agents Chemother. 1995 Nov;39(11):2541-3. (PMID: 8585741); Nanomedicine (Lond). 2016 Mar;11(6):673-92. (PMID: 27003448); Pharmaceutics. 2022 May 14;14(5):. (PMID: 35631644); Int J Oncol. 2019 Feb;54(2):407-419. (PMID: 30570109); J Toxicol. 2022 Oct 19;2022:8244340. (PMID: 36310641); Nanoscale Res Lett. 2018 Jul 17;13(1):214. (PMID: 30019092); Pharmaceutics. 2020 Feb 15;12(2):. (PMID: 32075296); Nanomaterials (Basel). 2021 May 01;11(5):. (PMID: 34062851); Chem Sci. 2018 Sep 6;9(42):8134-8141. (PMID: 30542564); Antibiotics (Basel). 2021 Sep 21;10(9):. (PMID: 34572720); Methods Mol Biol. 2017;1570:47-71. (PMID: 28238129); Chem Pharm Bull (Tokyo). 1995 Aug;43(8):1388-90. (PMID: 7553984); Chem Soc Rev. 2021 Oct 18;50(20):11614-11667. (PMID: 34661212); Eur J Pharm Sci. 1998 Apr;6(2):141-4. (PMID: 9795033); Nanomaterials (Basel). 2022 Sep 12;12(18):. (PMID: 36144948); Materials (Basel). 2022 May 20;15(10):. (PMID: 35629679); Pharmaceutics. 2022 Apr 18;14(4):. (PMID: 35456717); Polymers (Basel). 2021 Nov 27;13(23):. (PMID: 34883649); Bioorg Med Chem Lett. 2012 Dec 1;22(23):7060-4. (PMID: 23099095); Pharmaceutics. 2021 Aug 28;13(9):. (PMID: 34575432) |
| Contributed Indexing: | Keywords: anticancer; co-precipitation; magnetite nanoparticles; microwave-assisted hydrothermal synthesis; usnic acid |
| Substance Nomenclature: | 0 (Magnetite Nanoparticles); 0W584PFJ77 (usnic acid); 0 (Benzofurans) |
| Entry Date(s): | Date Created: 20230714 Date Completed: 20230717 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10343309 |
| DOI: | 10.3390/molecules28135198 |
| PMID: | 37446861 |
| Database: | MEDLINE |
Journal Article