Urinary TNF-α as a potential biomarker for chronic primary low back pain.
| Title: | Urinary TNF-α as a potential biomarker for chronic primary low back pain. |
|---|---|
| Authors: | Gevers-Montoro C; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Puente-Tobares M; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.; Monréal A; Madrid College of Chiropractic - RCU María Cristina, Madrid, Spain.; Conesa-Buendía FM; Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Madrid, Spain.; Piché M; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; CogNAC Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Ortega-De Mues A; Fujitega Research Foundation, Madrid, Spain. |
| Source: | Frontiers in integrative neuroscience [Front Integr Neurosci] 2023 Jun 28; Vol. 17, pp. 1207666. Date of Electronic Publication: 2023 Jun 28 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477950 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5145 (Print) Linking ISSN: 16625145 NLM ISO Abbreviation: Front Integr Neurosci Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007- |
| Abstract: | Introduction: Over two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic low back pain and who will recover from an acute episode. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated with poor recovery and persistent pain following an acute episode of LBP. Inflammatory cytokines may also mediate mechanisms involved in nociplastic pain, and thus, have significant implications in chronic primary low back pain (CPLBP).; Methods: This study aimed to investigate the potential of urinary TNF-α levels for predicting outcomes and characterizing clinical features of CPLBP patients. Twenty-four patients with CPLBP and 24 sex- and age-matched asymptomatic controls were recruited. Urinary TNF-α concentrations were measured at baseline and after 4 weeks, during which CPLBP patients underwent spinal manipulative therapy (SMT).; Results: Concentrations of TNF-α were found to be elevated in baseline urine samples of CPLBP patients compared to asymptomatic controls. Moreover, these values differed among patients depending on their pain trajectory. Patients with persistent pain showed higher levels of TNF-α, when compared to those with episodic CPLBP. Furthermore, baseline TNF-α concentrations and their changes after 4 weeks predicted alterations in pain intensity and disability following SMT in patients with CPLBP.; Discussion: These findings warrant further research on the potential use of urinary TNF-α concentrations as a prognostic biomarker for CPLBP.; (Copyright © 2023 Gevers-Montoro, Puente-Tobares, Monréal, Conesa-Buendía, Piché and Ortega-De Mues.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: TNF-alpha; back pain; chronic pain; instrument-assisted spinal manipulation; pain trajectories; urine biomarkers |
| Entry Date(s): | Date Created: 20230714 Latest Revision: 20230718 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10336221 |
| DOI: | 10.3389/fnint.2023.1207666 |
| PMID: | 37449008 |
| Database: | MEDLINE |
Journal Article