Microwave-Assisted Hydrothermal Treatment of Multifunctional Substituted Hydroxyapatite with Prospective Applications in Bone Regeneration.
| Title: | Microwave-Assisted Hydrothermal Treatment of Multifunctional Substituted Hydroxyapatite with Prospective Applications in Bone Regeneration. |
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| Authors: | Burdusel AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Splaiul Independentei 54, 050044 Bucharest, Romania.; Neacsu IA; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Splaiul Independentei 54, 050044 Bucharest, Romania.; Birca AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Splaiul Independentei 54, 050044 Bucharest, Romania.; Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Splaiul Independentei 54, 050044 Bucharest, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Splaiul Independentei 54, 050044 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Holban AM; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 077206 Bucharest, Romania.; Curutiu C; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 077206 Bucharest, Romania.; Ditu LM; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 077206 Bucharest, Romania.; Stan M; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.; Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Splaiul Independentei 54, 050044 Bucharest, Romania. |
| Source: | Journal of functional biomaterials [J Funct Biomater] 2023 Jul 19; Vol. 14 (7). Date of Electronic Publication: 2023 Jul 19. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101570734 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4983 (Print) Linking ISSN: 20794983 NLM ISO Abbreviation: J Funct Biomater Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel : MDPI AG |
| Abstract: | Orthopedic bone graft infections are major complications in today's medicine, and the demand for antibacterial treatments is expanding because of the spread of antibiotic resistance. Various compositions of hydroxyapatite (HAp) in which Calcium (Ca2+) ions are substituted with Cerium (Ce3+) and Magnesium (Mg2+) are herein proposed as biomaterials for hard tissue implants. This approach gained popularity in recent years and, in the pursuit of mimicking the natural bone mineral's composition, over 70 elements of the Periodic Table were already reported as substituents into HAp structure. The current study aimed to create materials based on HAp, Hap-Ce, and Hap-Mg using hydrothermal maturation in the microwave field. This route has been considered a novel, promising, and effective way to obtain monodisperse, fine nanoparticles while easily controlling the synthesis parameters. The synthesized HAp powders were characterized morphologically and structurally by XRD diffraction, Dynamic light scattering, zeta potential, FTIR spectrometry, and SEM analysis. Proliferation and morphological analysis on osteoblast cell cultures were used to demonstrate the cytocompatibility of the produced biomaterials. The antimicrobial effect was highlighted in the synthesized samples, especially for hydroxyapatite substituted with cerium. Therefore, the samples of HAp substituted with cerium or magnesium are proposed as biomaterials with enhanced osseointegration, also having the capacity to reduce device-associated infections. |
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| Contributed Indexing: | Keywords: bone regeneration; cerium; hydroxyapatite; magnesium |
| Entry Date(s): | Date Created: 20230728 Latest Revision: 20230801 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC10381662 |
| DOI: | 10.3390/jfb14070378 |
| PMID: | 37504872 |
| Database: | MEDLINE |
Journal Article