Associations of meditation with telomere dynamics: a case-control study in healthy adults.
| Title: | Associations of meditation with telomere dynamics: a case-control study in healthy adults. |
|---|---|
| Authors: | Dasanayaka NN; Research Promotion and Facilitation Centre, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.; Sirisena ND; Department of Anatomy, Genetics & Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.; Samaranayake N; Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. |
| Source: | Frontiers in psychology [Front Psychol] 2023 Jul 14; Vol. 14, pp. 1222863. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101550902 Publication Model: eCollection Cited Medium: Print ISSN: 1664-1078 (Print) Linking ISSN: 16641078 NLM ISO Abbreviation: Front Psychol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Pully, Switzerland : Frontiers Research Foundation |
| Abstract: | Introduction: Telomeres are protective end caps of chromosomes which naturally shorten with each cell division and thus with age. Short telomeres have been associated with many age-related diseases. Meditation has come to the fore as a mind-body practice which could influence the telomere dynamics underlying these phenomena. We previously reported meditation to be associated with higher telomerase levels, mindfulness and quality of life. Here, reporting on the same study population, we describe associations between long-term meditation and telomere length (TL), expression of hTERT and hTR genes and methylation of the promoter region of hTERT gene.; Methods: Thirty healthy meditators and matched non-meditators were recruited. TL was measured using quantitative PCR, gene expression was assessed using reverse transcriptase PCR, and methylation level was quantified by bisulfite-specific PCR followed by Sanger sequencing. Comparisons between meditators and controls were carried out using t-tests, while Pearson correlation was used to identify correlations, and regression was used to identify predictors.; Results: Males comprised 63.4% of each group with an average age of 43 years. On average, they had meditated daily for 5.82 h (±3.45) for 6.8 years (±3.27). Meditators had longer relative TLs (p = 0.020), and TL decreased with age (p |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: gene expression; hTERT; hTR; meditation; telomerase; telomere length |
| Molecular Sequence: | figshare 10.6084/m9.figshare.23537952 |
| Entry Date(s): | Date Created: 20230731 Date Completed: 20260310 Latest Revision: 20260310 |
| Update Code: | 20260310 |
| PubMed Central ID: | PMC10380951 |
| DOI: | 10.3389/fpsyg.2023.1222863 |
| PMID: | 37519381 |
| Database: | MEDLINE |
Journal Article